PD-1 specific antibodies and uses thereof

Patent metadata

Field	Value
Publication number	US-8927697-B2
Application number	US-200913062559-A
Country	US
Kind code	B2
Filing date	Sep 14, 2009
Priority date	Sep 12, 2008
Publication date	Jan 6, 2015
Grant date	Jan 6, 2015

Abstract

One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.

First claim

We claim:

1. An isolated antibody selected from:
a) a monoclonal antibody that binds PD-1 and is produced by the hybridoma clone 10 or antigen binding fragment thereof, said hybridoma clone being deposited with the European Collection of Cell Cultures (ECACC) under accession number 08090902;
b) an isolated antibody that binds PD-1 or antigen binding fragment comprising SEQ ID NO: 8 and SEQ ID NO: 10; or
c) a bispecific, humanized, single-chain, chimeric, synthetic or recombina…

Assignees

• Davis Simon
• Tyson Kerry Louise
• Isis Innovation

Inventors

• Davis Simon
• Tyson Kerry Louise

Classifications

• A61P41/00

  Human Necessities · mapped topic

• A61P3/10

  Human Necessities · mapped topic

• A61P37/00

  Human Necessities · mapped topic

• A61P37/02

  Human Necessities · mapped topic

• A61P37/08

  Human Necessities · mapped topic