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Functionalization of polyglycolides by “click” chemistry
US8927682B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8927682-B2 |
| Application number | US-22954408-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 25, 2008 |
| Priority date | Aug 24, 2007 |
| Publication date | Jan 6, 2015 |
| Grant date | Jan 6, 2015 |
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Abstract
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Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
First claim
Opening claim text (preview).
What is claimed is: 1. A poly(glycolide) polymer consisting of a polymerized alkynyl-substituted glycolide, the alkynyl-substituted glycolide comprising an alkynyl group. 2. The poly(glycolide) polymer of claim 1 , wherein the alkynyl group contains 3 to 12 carbon atoms. 3. The poly(glycolide) polymer of claim 2 , wherein the alkynyl group comprises a propargyl group having a terminal alkynyl group. 4. The poly(glycolide…
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- C08G63/08Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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- What does patent US8927682B2 cover?
- Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups r…
- Who is the assignee on this patent?
- Baker Gregory L, Smith Iii Milton R, Jiang Xuwei, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C08G63/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).