Novel heterocyclic antiestrogens
US-2018354936-A1 · Dec 13, 2018 · US
US8927591B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8927591-B2 |
| Application number | US-200913128620-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 11, 2009 |
| Priority date | Nov 14, 2008 |
| Publication date | Jan 6, 2015 |
| Grant date | Jan 6, 2015 |
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The present invention relates to novel compounds, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
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What is claimed is: 1. A compound of Formula I: wherein: q is 1, 2, 3, or 4; y is 0-2; R 1 is selected from the group consisting of —OR 18 , hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, thio,…
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