Thiochromene derivatives as HIF hydroxylase inhibitors

US8927591B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-8927591-B2
Application numberUS-200913128620-A
CountryUS
Kind codeB2
Filing dateNov 11, 2009
Priority dateNov 14, 2008
Publication dateJan 6, 2015
Grant dateJan 6, 2015

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  2. Abstract

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Abstract

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The present invention relates to novel compounds, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

First claim

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What is claimed is: 1. A compound of Formula I: wherein: q is 1, 2, 3, or 4; y is 0-2; R 1 is selected from the group consisting of —OR 18 , hydroxy, acyloxy, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, aryloxy, substituted aryloxy, heteroaryloxy, substituted heteroaryloxy, heterocyclyloxy, substituted heterocyclyloxy, thio,…

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Frequently asked questions

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What does patent US8927591B2 cover?
The present invention relates to novel compounds, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
Who is the assignee on this patent?
Ho Wen-Bin, Wright Lee R, Turtle Eric D, and 3 more
What technology area does this patent fall under?
Primary CPC classification C07D335/06. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Jan 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).