Treatment of inflammatory conditions by modulation of hyaluronan and hyaluronidase activity
US-2017348338-A1 · Dec 7, 2017 · US
Extended soluble PH20 polypeptides and uses thereof
US8927249B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8927249-B2 |
| Application number | US-65324509-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 9, 2009 |
| Priority date | Dec 9, 2008 |
| Publication date | Jan 6, 2015 |
| Grant date | Jan 6, 2015 |
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Abstract
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Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
First claim
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The invention claimed is: 1. An extended soluble PH20 hyaluronidase (esPH20), wherein: the esPH20 polypeptide exhibits hyaluronidase activity at neutral pH; the esPH20 polypeptide is secreted when expressed in a mammalian cell; the esPH20 polypeptide is soluble; and the esPH20 polypeptide is selected from among: a polypeptide that consists of the sequence of amino acids set forth as amino acid residues 36-495, 36-496, 36-497, 36-498, 36-499 or 36-500 of SEQ ID NO: 107; or…
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Frequently asked questions
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- What does patent US8927249B2 cover?
- Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
- Who is the assignee on this patent?
- Wei Ge, Selvam Krishnasamy Panneer, Bookbinder Louis, and 2 more
- What technology area does this patent fall under?
- Primary CPC classification C12N9/2474. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).