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Fusion protein capable of binding VEGF-A and TNF-alpha
US8927232B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-8927232-B2 |
| Application number | US-63601309-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 11, 2009 |
| Priority date | Dec 11, 2008 |
| Publication date | Jan 6, 2015 |
| Grant date | Jan 6, 2015 |
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Abstract
Official abstract text for this publication.
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1.
First claim
Opening claim text (preview).
What is claimed is: 1. A fusion polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide consisting of: (a) TNFR2 component and VEGFR1 component operatively linked to (b) a multimerizing component, wherein the TNFR2 component consists of a fragment of the extracellular domain of TNFR2 comprising the amino acid sequence of cysteine rich domain 1, cysteine rich domain 2, cysteine rich domain 3, and cysteine rich domain 4 of the extracellular domain of TNFR2…
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Human Necessities · mapped topic
Human Necessities · mapped topic
- C07K16/241Primary
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
- C07K14/71Primary
Chemistry & Metallurgy · mapped topic
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Frequently asked questions
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- What does patent US8927232B2 cover?
- The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide s…
- Who is the assignee on this patent?
- Jung Keehoon, Koh Young Jun, Lee Gyun Min, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification C07K16/241. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 06 2015 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).