Composition and use of same for controlling infections in aquatic organisms

Patent metadata

Field	Value
Publication number	US-2026083697-A1
Application number	US-202319108800-A
Country	US
Kind code	A1
Filing date	Sep 5, 2023
Priority date	Sep 5, 2022
Publication date	Mar 26, 2026
Grant date	—

Abstract

The present application, provides, inter alia, a composition including an esterified fatty acid, including a fatty acid comprising 4 to 24 carbon atoms, for use in a method for prevention or treatment of a monogenean infection in an aquatic organism in need thereof.

First claim

1 . A method for preventing or treating a pathogenic infection in an aquatic organism in need thereof, the method comprising administering to said aquatic organism a therapeutically effective amount of an esterified fatty acid, comprising a fatty acid chain of 4 to 24 carbon atoms.

2 . The method of claim 1 , wherein said esterified fatty acid is ethyl ester, methyl ester, butyl ester, propyl ester, or a combination thereof.

3 . The method of claim 1 , wherein: (i) said esterified fatty acid comprises a plurality of types of esterified fatty acids, wherein each of said esterified fatty acids comprises a fatty acid chain of 4 to 24 carbon atoms; (ii) said esterified fatty acid comprises an esterified fatty acid being selected from the group consisting of: eicosapentaenoic acid (EPA), myristic acid, palmitic acid, palmitoleic acid, and any combination thereof; (iii) said esterified fatty acid comprises an esterified EPA; (iv) said fatty acid chain is of 9 to 22 carbon atoms; or (v) any combination of (i) to (iv).

4 .- 6 . (canceled)

7 . The method of claim 1 , wherein said fatty acid is a saturated fatty acid or an unsaturated fatty acid, with 1 to 6 double bonds.

8 . (canceled)

9 . The method of claim 1 , wherein said composition further comprises a detergent, and optionally wherein said detergent is present in said composition in an amount of 0.1-5% by weight of said composition.

10 . (canceled)

11 . The method of claim 1 , wherein: (i) said pathogenic infection excludes bacterial infection; (ii) said administering comprises contacting a body of water comprising said aquatic organism with said esterified fatty acid, and optionally wherein said method comprises contacting said body of water with an amount of 0.1 to 500 μg of said esterified fatty acid per ml of water of said body of water, contacting said body of water with an amount of 1 to 50 μg of said esterified fatty acid per ml of water of said body of water, or both; or (iii) both (i) and (ii).

12 .- 14 . (canceled)

15 . The method of claim 1 , wherein: (i) said aquatic organism is selected from the group consisting of: fish, crustacean, mollusk, and any combination thereof; (ii) said pathogenic infection comprises any one of a monogenean infection, a protozoan infection, or both, and optionally wherein monogenean infection is induced by Gyrodactylus turnbulli , said protozoan infection is induced by a protozoan belonging to any one of the genera Trichodina and Tetrahymena , or both; or (iii) both (i) and (ii).

16 .- 18 . (canceled)

19 . A composition comprising an esterified fatty acid, comprising a fatty acid chain of 4 to 24 carbon atoms, and an agriculturally or aquaculturally acceptable carrier, for prevention, treatment, or both, of a pathogenic infection in an aquatic organism in need thereof.

20 . The composition of claim 19 , further comprising a detergent, and optionally wherein said detergent is present in said composition in an amount of 0.1-5% by weight of said composition, said detergent comprises Kolliphor EL, or both.

21 .- 22 . (canceled)

23 . The composition of claim 19 , comprising an extract of a microalga, or any fraction thereof, and optionally wherein said microalga is selected from the group consisting of: Phaeodactylum tricornutum, Odontella aurita, Nitzschia laevis, Nannochloropsis oceanica, Nannochloropsis limnetica, Nannochloropsis oculata , Microchloropsis gaditana , Microchloropsis salina , Monodopsis subterranean, Tribonema sp, and any combination thereof.

24 . (canceled)

25 . The composition of claim 19 , wherein said esterified fatty acid is ethyl ester, methyl ester, butyl ester, propyl ester, or a combination thereof.

26 . The composition of claim 19 , wherein said esterified fatty acid comprises a plurality of types of esterified fatty acids, wherein each of said esterified fatty acids comprises a fatty acid chain of 4 to 24 carbon atoms.

27 . The composition of claim 19 , wherein said esterified fatty acid comprises an esterified fatty acid being selected from the group consisting of: eicosapentaenoic acid (EPA), myristic acid, palmitic acid, palmitoleic acid, and any combination thereof.

28 . The composition of claim 19 , wherein said esterified fatty acid comprises an esterified EPA.

29 . The composition of claim 19 , wherein said fatty acid chain is of 9 to 22 carbon atoms.

30 . The composition of claim 19 , wherein said pathogenic infection excludes bacterial infection.

31 . The composition of claim 19 , wherein said pathogenic infection comprises any one of a monogenean infection, a protozoan infection, or both, and optionally wherein monogenean infection is induced by Gyrodactylus turnbulli , said protozoan infection is induced by a protozoan belonging to any one of the genera Trichodina and Tetrahymena , or both.

32 .- 33 . (canceled)

34 . The composition of claim 19 , being administered or supplemented into a body of water comprising said aquatic organism, such that a concentration of 1 to 50 μg of said esterified fatty acid per ml of water of said body of water is obtained.

35 . The composition of claim 19 , wherein said aquatic organism is selected from the group consisting of: fish, crustacean, mollusk, and any combination thereof.

36 . The composition of claim 19 , formulated for administration to a body of water, and optionally wherein said body of water comprises said aquatic organism, said composition is formulated for administration to an aquatic organism while residing, being cultured, or both, in said body of water, or both.

37 .- 38 . (canceled)

Assignees

• B G Negev Technologies And Applications Ltd At Ben Gurion Univ

Inventors

• Khozin-Goldberg Inna
• Zilberg Dina
• Zorin Boris
• Kim Ji Hyun
• Jawaji Arunjyothi

Classifications

• A61K31/202

  having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) · CPC title

• A61K31/201

  having one or two double bonds, e.g. oleic, linoleic acids · CPC title

• A61P33/02

  Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis · CPC title

• A61L2103/05

  Living organisms or biological materials · CPC title

• A61L2/18

  Liquid substances · CPC title