Sample processing assembly for treatment of a sample on a substrate

Patent metadata

Field	Value
Publication number	US-2026056095-A1
Application number	US-202218702207-A
Country	US
Kind code	A1
Filing date	Dec 22, 2022
Priority date	Dec 23, 2021
Publication date	Feb 26, 2026
Grant date	—

Abstract

A processing assembly for treatment of a sample on a substrate, including: a mounting block including a mounting surface for the substrate; a closure body configured to support a cover member; a closure body arm engaging with the closure body so that rotation of the arm about a pivot axis causes movement of the closure body between the open and closed positions; and a substrate retaining mechanism. The mechanism includes: a cam, and a substrate retaining arm including a cam follower engaging the cam. When the closure body is closed and the cover member engages the substrate, the substrate retaining arm is clear of the substrate, as the closure body arm commences rotation to enable the closure body to rotate towards the open position, but whilst the closure body remains in a closed position, the substrate retaining arm moves into engagement with the substrate, and disengages with the substrate.

First claim

1 . A sample processing assembly for treatment of a sample on a substrate, the assembly including:
a mounting block including a mounting surface for the substrate; a closure body configured to support a cover member, the closure body being rotatable about a first pivot axis between an open position and a closed position, such that when the substrate is placed in the assembly and the closure body is in the closed position, the cover member engages the substrate to form a reaction chamber for processing the sample; a closure body arm rotatable about the second pivot axis and engaging with the closure body so that rotation of the arm about the second pivot axis causes movement of the closure body between the open and closed positions; and a substrate retaining mechanism including: a cam, and a substrate retaining arm rotatable about the first pivot axis, the substrate retaining arm including a cam follower for sliding engagement with the cam, wherein the substrate retaining mechanism is configured so that when the closure body is closed and the cover member engages the substrate, the substrate retaining arm is clear of the substrate, as the closure body arm commences rotation to enable the closure body to rotate towards the open position, but whilst the closure body remains in a closed position, the substrate retaining arm moves into engagement with the substrate, and once the cover member is fully separated from substrate, the substrate retaining arm disengages with the substrate.

2 . A sample processing assembly according to claim 1 , wherein the cam is a grooved cam formed in a side wall of the closure body arm.

3 . A sample processing assembly according to claim 1 , wherein the cam follower is a cam pin projecting laterally from the substrate retaining arm.

4 . A sample processing assembly according to claim 1 , further including a first pivot pin to enable rotation of the cover body about the first pivot axis.

5 . A sample processing assembly according to claim 4 , wherein the substrate retaining arm is attached to and rotatable about the first pivot pin.

6 . A sample processing assembly according to claim 4 , and further including a second pivot pin located through the mounting block to enable rotation of the closure body arm about the second pivot axis.

7 . A sample processing assembly according to claim 1 , wherein the substrate retaining arm includes protrusions for making contact with and applying a retaining force to the substrate.

8 . A sample processing assembly according to claim 1 , wherein the substrate retaining mechanism is further configured so that the substrate retaining arm disengages from the substrate perpendicular to the surface of the substrate.

9 . A sample processing assembly according to claim 1 , wherein the closure body arm includes a lateral projection for engaging with the closure body.

10 . A substrate retaining mechanism for use with a sample processing assembly for treatment of a sample on a substrate, wherein the assembly includes: a mounting block including a mounting surface for the substrate; a closure body configured to support a cover member, the closure body being rotatable about a first pivot axis between an open position and a closed position, such that when the substrate is placed in the assembly and the closure body is in the closed position, the cover member engages the substrate to form a reaction chamber for processing the sample; and a closure body arm rotatable about the second pivot axis and engaging with the closure body so that rotation of the arm about the second pivot axis causes movement of the closure body between the open and closed positions,
the substrate retaining mechanism including: a cam, and a substrate retaining arm rotatable about the first pivot axis, the substrate retaining arm including a cam follower for sliding engagement with the cam, wherein the substrate retaining mechanism is configured so that when the closure body is closed and the cover member engages the substrate, the substrate retaining arm is clear of the substrate, as the closure body arm commences rotation to enable the closure body to rotate towards the open position, but whilst the closure body remains in a closed position, the substrate retaining arm moves into engagement with the substrate, and once the cover member is fully separated from substrate, the substrate retaining arm disengages with the substrate.

11 . A substrate retaining mechanism according to claim 10 , wherein the cam is a grooved cam formed in a side wall of the closure body arm.

12 . A substrate retaining mechanism according to claim 10 , wherein the cam follower is a cam pin projecting laterally from the substrate retaining arm.

13 . A substrate retaining mechanism according to claim 12 , the sample processing assembly including a first pivot pin to enable rotation of the cover body about the first pivot axis, wherein the substrate retaining arm is attached to and rotatable about the first pivot pin.

14 . A substrate retaining mechanism according to claim 10 , wherein the substrate retaining arm includes protrusions for making contact with and applying a retaining force to the substrate.

15 . A substrate retaining mechanism according to claim 10 , wherein the substrate retaining mechanism is further configured so that the substrate retaining arm disengages from the substrate perpendicular to the surface of the substrate.

Assignees

• Leica Biosystems Melbourne Pty

Inventors

• Me Phong Tan

Classifications

• G01N2035/00079

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