Assembling and growing cellular objects on a contact structure by means of axial and transverse acoustic radiation forces

Patent metadata

Field	Value
Publication number	US-2026028573-A1
Application number	US-202318995506-A
Country	US
Kind code	A1
Filing date	Jul 6, 2023
Priority date	Jul 21, 2022
Publication date	Jan 29, 2026
Grant date	—

Abstract

A device and method for assembling objects by generating an axial acoustic radiation force in order to position the objects on pressure nodes and/or antinodes and generating a transverse acoustic radiation force in order to move the thus positioned objects on a porous membrane contact structure.

First claim

1 - 10 . (canceled)

11 . A device for assembling objects, comprising:
a cavity configured to receive a fluid and the objects, a generating system configured to generate in the cavity, along an axial direction, a standing acoustic wave so as to produce an axial acoustic radiation force suitable for positioning objects on pressure nodes and/or antinodes formed by the acoustic wave, characterized in that it comprises a contact structure forming one or more surfaces extending along the axial direction and in that the generating system is configured to exert a transverse acoustic radiation force capable of displacing the objects towards the surface(s) of the contact structure.

12 . The device according to claim 11 , wherein the contact structure comprises one or more membranes.

13 . The device according to claim 12 , wherein the cavity comprises several chambers delimited by one or more of said membranes, each of the chambers preferably comprising a respective part of the objects.

14 . The device according to claim 12 , wherein one or more of said membranes are porous.

15 . The device according to claim 11 , wherein one or more of said surfaces formed by the contact structure are surfaces each extending around a respective direction, this direction preferably being parallel or oblique with respect to said axial direction.

16 . The device according to claim 11 , wherein the contact structure comprises or forms one or more electrodes.

17 . The device according to claim 11 , comprising elements, such as biological cells, connected to the contact structure in such a way as to allow interactions between these elements and one or more of said objects when said objects are moved towards the surfaces of the contact structure.

18 . The device according to claim 11 , wherein the generating system comprises one or more piezoelectric and/or ultrasonic transducers which can comprise several matrix-organized elements and/or one or more acoustic holographic lenses.

19 . The device according to claim 11 , wherein said objects comprise objects having a positive acoustic contrast with respect to the fluid so that the axial acoustic radiation force moves these objects towards the pressure nodes and/or objects having a negative acoustic contrast with respect to the fluid so that the axial acoustic radiation force moves these objects towards the pressure antinodes.

20 . A method for assembling objects using a device according to claim 11 , comprising generating the axial acoustic radiation force so as to position the objects on the pressure nodes and/or antinodes and generating the transverse acoustic radiation force so as to move the objects towards the surface(s) of the contact structure.

Assignees

• Centre Nat Rech Scient
• Ecole Superieure Physique & Chimie Ind Ville De Paris
• Univ Paris Cite
• Inst Nat Sante Rech Med
• Univ Sorbonne

Inventors

• Aider Jean-Luc
• Jeger-Madiot Nathan
• Peyrin Jean-Michel
• Hoyos Mauricio
• Dupuis Chloé

Classifications

• C12M25/14

  Scaffolds; Matrices (in general C12N5/0068) · CPC title

• C12M25/02

  Membranes; Filters (filters or filtration in general B01D24/00-B01D41/00) · CPC title

• C12M23/34

  Internal compartments or partitions · CPC title

• C12M35/04 Primary

  Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli · CPC title

• B01D2221/10

  Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues · CPC title