Methods and absorbent articles for inhibiting fecal protease activity

Patent metadata

Field	Value
Publication number	US-2026021219-A1
Application number	US-202319115884-A
Country	US
Kind code	A1
Filing date	Sep 29, 2023
Priority date	Sep 30, 2022
Publication date	Jan 22, 2026
Grant date	—

Abstract

Methods and postbiotic compositions which reduce fecal enzyme activity. as well as absorbent articles which comprise the postbiotic compositions are disclosed. The postbiotic compositions and absorbent articles of the present disclosure can prevent or reduce epidermal irritation and dermatitis in diapered area by reducing the activity of fecal enzymes. In one embodiment. the postbiotic composition comprises Saccharomyces lysate derived from Saccharomyces cerevisiae.

First claim

1 . A method of inhibiting activity of one or more fecal enzymes, the method comprising exposing the fecal enzymes to a postbiotic composition, wherein the postbiotic composition reduces the activity of one or more of the fecal enzymes by 10% or more compared to a control.

2 . The method of claim 1 , wherein the postbiotic composition comprises Saccharomyces lysate.

3 . The method of claim 2 , wherein the Saccharomyces lysate is derived from Saccharomyces cerevisiae.

4 . The method of claim 1 wherein the fecal enzyme is a serine protease.

5 . The method of claim 4 , wherein the serine protease is chymotrypsin or trypsin.

6 . The method of claim 1 , wherein the postbiotic composition further comprises one or more amino acids.

7 . The method of claim 6 , wherein the one or more amino acids are selected from the group comprising valine, threonine, glutamic acid, and glycine.

8 . The method of claim 1 , wherein the postbiotic composition further comprises disodium succinate.

9 . The method of claim 1 , wherein the postbiotic composition comprises OXY 229 PF.

10 . The method of claim 9 , wherein the amount of OXY 229 PF is between 0.5% to 10%.

11 . The method of claim 1 , wherein said fecal enzymes occur on an epidermal surface.

12 . The method of claim 1 , wherein the fecal enzyme activity is reduced by 10-90% or more compared to a control.

13 . A method of preventing or reducing fecal enzyme-related diaper dermatitis in a subject in need thereof, the method comprising providing a postbiotic composition to the subject, wherein the postbiotic composition helps reduce or prevent fecal enzyme-related diaper dermatitis by 1% or more compared to a control.

14 . The method of claim 13 , wherein the fecal-enzyme-related dermatitis is caused by one or more fecal enzymes.

15 . The method claim 14 , wherein said one or more fecal enzymes occur on an epidermal surface.

16 - 25 . (canceled)

26 . An absorbent article comprising a composition, wherein the composition comprises Saccharomyces lysate.

27 - 32 . (canceled)

33 . The absorbent article of claim 26 , wherein the absorbent article comprises diapers, diaper pants, training pants, youth pants, swim pants, feminine hygiene products, adult care garments, medical garments, surgical pads and bandages, other personal care or health care garments.

34 . The absorbent article of claim 33 , wherein the composition is disposed on a side of the absorbent article configured for contact with a wearer.

35 . The absorbent article of claim 34 , wherein the side of the absorbent article configured for contact with a wearer comprises a bodyside liner.

Assignees

• Kimberly Clark Co

Inventors

• Chon Suhyoun (Su)
• Rodriguez Karien J
• Sriwiriyanont Penkanok
• Peed Lindsay

Classifications

• A61L2300/434

  of enzymes · CPC title

• A61F2013/51117

  the lotion having skin care properties · CPC title

• A61F13/51113

  comprising an additive, e.g. lotion or odour control (A61F13/51108 takes precedence) · CPC title

• A61L15/40 Primary

  containing ingredients of undetermined constitution or reaction products thereof {, e.g. plant or animal extracts} · CPC title

• A61L2300/45

  Mixtures of two or more drugs, e.g. synergistic mixtures · CPC title