Mediated hydrogen anode for use in reductive electrosynthesis

Patent metadata

Field	Value
Publication number	US-2026015743-A1
Application number	US-202217853441-A
Country	US
Kind code	A1
Filing date	Jun 29, 2022
Priority date	Jun 29, 2021
Publication date	Jan 15, 2026
Grant date	—

Abstract

An electrosynthetic cell and its use are disclosed. The electrosynthetic cell can be used in a reductive electrosynthesis of one or more desired chemical products from one or more chemical reactants. The electrosynthetic cell comprises a hydrogen anode half-cell and a cathode half-cell. The hydrogen anode half-cell comprises hydrogen (H2), a first liquid phase solution that is in contact with an anode and a heterogeneous redox catalyst capable of catalyzing the oxidation of H2 to H+, and a redox mediator capable of transferring or accepting electrons and/or protons while undergoing reduction or oxidation. The cathode half-cell comprises a second liquid phase solution comprising the one or more chemical reactants that is in contact with a cathode and a reductive synthesis catalyst capable of catalyzing the reductive synthesis of the one or more desired chemical products from the one or more chemical reactants.

First claim

We claim:

1 . An electrosynthetic cell for use in a reductive electrosynthesis of one or more desired chemical products from one or more chemical reactants, the electrosynthetic cell comprising a hydrogen anode half-cell and a cathode half-cell,
wherein the hydrogen anode half-cell comprises: hydrogen (H 2 ); a first liquid phase solution that is in contact with an anode and a heterogeneous redox catalyst capable of catalyzing the oxidation of H 2 to H + , wherein the heterogeneous redox catalyst is not affixed to the anode; and a redox mediator, wherein the redox mediator is capable of transferring or accepting electrons and/or protons while undergoing reduction or oxidation; and wherein the cathode half-cell comprises: a second liquid phase solution, the second liquid phase solution comprising the one or more chemical reactants, that is in contact with a cathode and a reductive synthesis catalyst capable of catalyzing the reductive synthesis of the one or more desired chemical products from the one or more chemical reactants.

2 . The electrosynthetic cell of claim 1 , wherein the one or more chemical reactants comprise a first chemical reactant selected from an aryl halide, a heteroaryl halide, an alkenyl halide, or any combination thereof and a second chemical reactant selected from an alkyl halide, a cycloalkyl halide, a heterocycloalkyl halide, or any combination thereof.

3 . The electrosynthetic cell of claim 2 , wherein the molar ratio of the first chemical reactant to the second chemical reactant is from 1:1 to 1:2.

4 . The electrosynthetic cell of claim 2 , wherein the alkyl halide, the cycloalkyl halide, or the heterocycloalkyl halide is optionally substituted with one or more substituents selected from the group consisting of alkyl, haloalkyl, halo, CN, cycloalkyl optionally substituted with one or more halo, —O-cycloalkyl, heterocycloalkyl, —O-heterocycloalkyl, aryl, —O-aryl, heteroaryl, —O— heteroaryl, alkoxy, haloalkoxy, hydroxy, —C(O)OR 1 , —OC(O)R 1 , —C(O)R 1 , —NR 1 R 2 , —C(O)NR 1 R 2 and —NR 1 C(O)R 2 ; and
wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl, —C(O)—O-alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl.

5 . The electrosynthetic cell of claim 2 , wherein the aryl halide, the heteroaryl halide, or the alkenyl halide is optionally substituted with one or more substituents selected from the group consisting of alkyl, haloalkyl, halo, CN, —B(O 2 C 2 (CH 3 ) 4 ), cycloalkyl, —O-cycloalkyl, heterocycloalkyl, —O-heterocycloalkyl, aryl, —O-aryl, heteroaryl, —O-heteroaryl optionally substituted with NR 3 R 4 , alkoxy, haloalkoxy, hydroxy, —C(O)OR 3 , —OC(O)R 3 , —C(O)R 1 , —NR 3 R 4 , —C(O)NR 3 R 4 , and —NR 3 C(O)R 4 ; and
wherein R 3 and R 4 are independently selected from the group consisting of hydrogen, alkyl, —C(O)—O-alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl.

6 . The electrosynthetic cell of claim 1 , wherein the redox mediator is dissolved within the first liquid phase solution and is capable of moving between the anode and the redox catalyst and wherein the electrosynthetic cell is configured to reduce an oxidized form of the redox mediator at the redox catalyst and oxidize a reduced form of the redox mediator at the anode.

7 . The electrosynthetic cell of claim 6 , wherein the reduced form of the redox mediator is selected from the group consisting of 1,4-dihydroxybenzene, 9,10-dihydroxyanthracene, and combinations thereof, and
wherein the 1,4-dihydroxybenzene or 9,10-dihydroxyanthracene is optionally substituted with one or more substituents selected from the group consisting of alkyl and thioether substituted with sulfonate.

8 . The electrosynthetic cell of claim 2 , wherein the redox mediator is at least 0.1 mol % based on the molar amount of the first chemical reactant.

9 . The electrosynthetic cell of claim 1 , wherein the redox mediator has a concentration of at least 5 mM in the first liquid phase solution.

10 . The electrosynthetic cell of claim 1 , wherein the redox catalyst comprises one or more metals selected from the group consisting of Pt, Pd, and combinations thereof.

11 . The electrosynthetic cell of claim 1 , wherein the redox catalyst is at least 1 mol %, based on the molar amount of the redox mediator.

12 . The electrosynthetic cell of claim 1 , wherein the first liquid phase solution of the anode half-cell or the second liquid phase solution of the cathode half-cell is selected from the group consisting of N-methylpyrrolidone (NMP), N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA), N,N′-dimethylpropyleneurea (DMPU), propylene carbonate, tetrahydrofuran (THF), methanol (MeOH), acetonitrile (MeCN), 1,3-dimethyl-2-imidazolidinone (DMI), and combinations thereof.

13 . The electrosynthetic cell of claim 1 , wherein the first liquid phase solution of the anode half-cell or the second liquid phase solution of the cathode half-cell further comprises a supporting electrolyte selected from the group consisting of tetrabutylammonium hexafluorophosphate (NBu 4 PF 6 ), lithium bromide (LiBr), potassium hexafluorophosphate (KPF 6 ), cesium fluoride (CsF), lithium chloride (LiCl), tetrabutylammonium tetrafluoroborate (NBu 4 BF 4 ), potassium chloride (KCl), and combinations thereof.

14 . The electrosynthetic cell of claim 1 , wherein the reductive synthesis catalyst comprises Ni and one or more ligands selected from the group consisting of 4,4′-di-tert-butyl-2,2-dipyridyl (dtbbpy), 4,4,′,4″-tri-tert-butyl-2,2′:6′,2″-terpyridine (ttbtpy), 2,9-dimethylphenanthroline, bathocuperoine, 1,2-bis(diphenylphosphino)ethane, and combinations thereof.

15 . The electrosynthetic cell of claim 14 , wherein the one or more ligands comprise dtbbpy and ttbtpy, and the ratio of dtbbpy to ttbtpy is from 1:2 to 5:1.

16 . The electrosynthetic cell of claim 2 , wherein the reductive synthesis catalyst is from 0.1 mol % to 30 mol %, based on the molar amount of the first chemical reactant.

17 . The electrosynthetic cell of claim 2 , wherein the hydrogen anode half-cell further comprises a base selected from the group consisting of alkali carbonate, alkali hydroxide, alkali phosphate, alkali zeolite, strong base anion (SBA) exchange resin, and combinations thereof.

18 . The electrosynthetic cell of claim 17 , wherein a molar ratio of the base to the first chemical reactant is from 1:1 to 1:4.

19 . The electrosynthetic cell of claim 1 , wherein the cathode half-cell further comprises one or more desired chemical products and the one or more desired chemical products comprise a reductive C(sp 2 )-C(sp 3 ) coupled product.

20 . The electrosynthetic cell of claim 1 , further comprising a device capable of applying an external electromotive force to the anode and the cathode to remove electrons from the anode and to add electrons to the cathode.

21 . The electrosynthetic cell of claim 20 , wherein the external electromotive force has a current density of from 0.01 mA·cm −2 to 20 mA·cm −2 .

22 . The electrosynthetic cell of claim 1 , further comprising an anion exchange membrane or a cation exchange membrane separating the hydrogen anode half-cell and the cathode half-cell.

23 . A method of using the electrosynthetic cell of claim 1 to produce the one or more desired chemical products from the one or more chemical reactants, the method comprising applying an external electromotive force to remove electrons from the anode and to add

Assignees

• Wisconsin Alumni Res Found

Inventors

• Stahl Shannon
• Gerken James
• Twilton Jack
• Johnson Mathew
• Root Thatcher

Classifications

• H01M8/0656

  by electrochemical means (H01M8/065 takes precedence) · CPC title

• C25B1/02 Primary

  Hydrogen or oxygen · CPC title

• C25B11/042 Primary

  Electrodes formed of a single material · CPC title

• C25B9/19

  with diaphragms · CPC title

• C25B3/05

  Heterocyclic compounds · CPC title