Method and apparatus for quantitative and depth resolved hyperspectral fluorescence and reflectance imaging for surgical guidance
US-11857317-B2 · Jan 2, 2024 · US
US2025387053A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2025387053-A1 |
| Application number | US-202318839029-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 6, 2023 |
| Priority date | Mar 16, 2022 |
| Publication date | Dec 25, 2025 |
| Grant date | — |
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A medical light source device includes a visible light source that emits normal light in a visible wavelength band, and a plurality of excitation light sources that emits a plurality of kinds of excitation light corresponding to a plurality of kinds of drugs each emitting fluorescence upon irradiation with the excitation light.
Opening claim text (preview).
1 . A medical light source device comprising: a visible light source configured to emit normal light in a visible wavelength band; and a plurality of excitation light sources configured to emit a plurality of kinds of excitation light corresponding to a plurality of kinds of drugs each emitting fluorescence upon irradiation with the excitation light. 2 . The medical light source device according to claim 1 , wherein the visible light source is configured to emit the normal light in a time division manner, and the plurality of excitation light sources are configured to simultaneously and continuously emit the plurality of kinds of excitation light. 3 . The medical light source device according to claim 1 , wherein the visible light source is configured to emit the normal light in a time division manner, and the plurality of excitation light sources are configured to sequentially emit the plurality of kinds of excitation light with emission timing shifted during an interval of emission of the normal light from the visible light source in the time division manner. 4 . The medical light source device according to claim 3 , wherein the plurality of excitation light sources include three or more excitation light sources and are configured to sequentially emit the plurality of kinds of excitation light with emission timing shifted in order that the excitation light sources whose wavelength bands of fluorescence to be generated are closest to each other do not continuously emit the plurality of kinds of excitation light, during the interval of emission of the normal light from the visible light source in the time division manner. 5 . The medical light source device according to claim 1 , further comprising a plurality of dichroic mirrors configured to cause the normal light emitted from the visible light source and the plurality of kinds of excitation light emitted from the plurality of excitation light sources to travel in an identical direction, wherein an arrangement order of the plurality of excitation light sources relative to an emission port at which the normal light and the plurality of kinds of excitation light are emitted from the medical light source device corresponds to an order of magnitude of peak wavelengths of the excitation light emitted from the plurality of excitation mirror light sources. 6 . The medical light source device according to claim 5 , wherein the plurality of excitation light sources are arranged closer to the emission port as the excitation light to be emitted has a larger peak wavelength. 7 . The medical light source device according to claim 6 , wherein the visible light source is arranged at a position closer to the emission port than the plurality of excitation light sources. 8 . A medical observation system comprising: a medical light source device including a visible light source configured to emit normal light in a visible wavelength band, and a plurality of excitation light sources configured to emit a plurality of kinds of excitation light corresponding to a plurality of kinds of drugs each emitting fluorescence upon irradiation with the excitation light; an imaging device configured to image the normal light emitted from the visible light source and reflected by a subject and fluorescence emitted from the plurality of kinds of drugs in the subject upon emission of the plurality of kinds of excitation light from the plurality of excitation mirror light sources; a display device configured to display a captured image captured by the imaging device; and a control device configured to control the medical light source device, the imaging device and the display device. 9 . The medical observation system according to claim 8 , wherein the control device is configured to cause the imaging device to sequentially generate a normal-light image that is the captured image obtained by imaging the normal light and a fluorescence image that is the captured image obtained by imaging the fluorescence in a period shorter than a frame period in which the captured image of one frame is displayed on the display device, and a difference in time between timing to finish generation of the normal-light image by the imaging device and timing to start display of the captured image on the display device is smaller than a difference in time between timing to finish generation of the fluorescence image by the imaging device and the timing to start display. 10 . The medical observation system according to claim 8 , wherein the control device is configured to cause the imaging device to sequentially generate a normal-light image that is the captured image obtained by imaging the normal light and a fluorescence image that is the captured image obtained by imaging the fluorescence in a period shorter than a frame period in which the captured image of one frame is displayed on the display device, and a difference in time between timing to finish generation of the fluorescence image by the imaging device and timing to start display of the captured image on the display device is smaller than a difference in time between timing to finish generation of the normal-light image by the imaging device and the timing to start display.
for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title
invasive, e.g. introduced into the body by a catheter · CPC title
mounted on an invasive device · CPC title
using infrared radiation · CPC title
by measuring fluorescence emission · CPC title
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