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US-2024190925-A1 · Jun 13, 2024 · US
L-histidine export protein and method of producing l-histidine using same
US2025382648A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2025382648-A1 |
| Application number | US-202318877252-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jun 22, 2023 |
| Priority date | Jun 23, 2022 |
| Publication date | Dec 18, 2025 |
| Grant date | — |
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- Title
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Abstract
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The present application discovers a histidine export protein having an ability to export L-histidine or a variant thereof, and expresses same in a microorganism having an ability to produce L-histidine, thereby dramatically improving L-histidine production.
First claim
Opening claim text (preview).
1 . A mutant L-histidine export protein, in which the amino acid corresponding to the 92th residue of the amino acid sequence of SEQ ID NO: 13 is substituted with another amino acid. 2 . The protein according to claim 1 , wherein the another amino acid is cysteine, glutamic acid, serine, threonine, asparagine, or glutamine. 3 . The protein according to claim 1 , wherein the another amino acid is cysteine. 4 . The protein according to claim 1 , wherein the protein has sequence identity of 99% or more to the amino acid sequence of SEQ ID NO: 48. 5 . A polynucleotide encoding the protein according to claim 1 . 6 . A microorganism, comprising the protein according to claim 1 or a polynucleotide encoding the protein. 7 . The microorganism according to claim 6 , wherein the microorganism has L-histidine production ability. 8 . The microorganism according to claim 6 , wherein the microorganism is the genus Corynebacterium or the genus of Escherichia. 9 . The microorganism according to claim 8 , wherein the microorganism is Corynebacterium glutamicum or Escherichia coli. 10 . A composition for producing L-histidine, comprising the protein according to claim 1 , a polynucleotide encoding the protein, or a recombinant microorganism comprising the polynucleotide. 11 . A method for producing L-histidine, comprising culturing a microorganism comprising the protein according to claim 1 or a polynucleotide encoding the protein in a medium. 12 . The method for producing L-histidine according to claim 11 , further comprising recovering L-histidine from the cultured microorganism or medium, after the culturing. 13 . The protein according to claim 1 , wherein the protein comprises an amino acid sequence having sequence identity of at least 90% to the amino acid sequence of SEQ ID NO: 13.
Assignees
Inventors
Classifications
Bacteria; Culture media therefor · CPC title
- C07K14/195Primary
from bacteria · CPC title
Escherichia coli · CPC title
Corynebacterium · CPC title
- C12P13/24Primary
Proline; Hydroxyproline; Histidine · CPC title
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Frequently asked questions
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- What does patent US2025382648A1 cover?
- The present application discovers a histidine export protein having an ability to export L-histidine or a variant thereof, and expresses same in a microorganism having an ability to produce L-histidine, thereby dramatically improving L-histidine production.
- Who is the assignee on this patent?
- Cj Cheiljedang Corp
- What technology area does this patent fall under?
- Primary CPC classification C07K14/195. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Dec 18 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).