Dihydroberberine composition and use thereof

Patent metadata

Field	Value
Publication number	US-2025288564-A1
Application number	US-202519066544-A
Country	US
Kind code	A1
Filing date	Feb 28, 2025
Priority date	Aug 30, 2022
Publication date	Sep 18, 2025
Grant date	—

Abstract

Disclosed herein are a dihydroberberine composition and use thereof in the preparation of medicaments, nutritional products, health-care products, foods and beverages for regulating the intestinal flora. The dihydroberberine composition of the present invention can significantly increase the level of a first intestinal microbiota in a subject, while reducing the level of a second intestinal microbiota in the subject, thereby improving the intestinal health.

First claim

What is claimed is:

1 . A method for regulating or improving intestinal health in a subject, wherein the method comprises administering a composition comprising dihydroberberine or a derivative thereof to the subject; wherein the composition comprising dihydroberberine or a derivative thereof increases a level of a first intestinal microbiota in the subject; the first intestinal microbiota is selected from one or more of the following: Lactobacillus acidophilus, Akkermansia muciniphila, Faecalibacterium Prausnitzii, Bacteroides fragilis.

2 . The method of claim 1 , wherein the method further comprises reducing a level of a second intestinal microbiota in the subject, wherein the second intestinal microbiota is Klebsiella pneumoniae or Desulfovibrio.

3 . The method of claim 1 , wherein the first intestinal microbiota is a beneficial microbiota or conditional pathogenic bacteria.

4 . The method of claim 2 , wherein the second intestinal microbiota is a harmful microbiota.

5 . The method of claim 1 , wherein the composition comprising dihydroberberine or a derivative thereof is formulated into a nutritional supplement, food, beverage, animal feed or medicament.

6 . The method of claim 1 , wherein the composition comprising dihydroberberine or a derivative thereof is prepared into a solid preparation or liquid preparation.

7 . The method of claim 1 , wherein the composition comprising dihydroberberine or a derivative thereof is administered to the subject at a dosage of 30 to 1800 mg per day.

8 . The method of claim 1 , wherein the composition comprising dihydroberberine or a derivative thereof is in a form of a suppository, tablet, pill, granule, powder, film, capsule, beverage, aerosol, spirit, tincture, tonic, liquid suspension or syrup.

9 . The method of claim 1 , wherein the composition comprising dihydroberberine or a derivative thereof is administered to the subject at a dosage of 50 to 1000 mg per day.

Assignees

• Nanjing Nutrabuilding Bio Tech Co Ltd

Inventors

• Jiang Long
• Liao Kylin
• Zhang Yunhua

Classifications

• A61K31/4375 Primary

  the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61P1/00 Primary

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23K20/132

  containing only one nitrogen as hetero atom · CPC title