Live mycoplasma gallisepticum vaccines

Patent metadata

Field	Value
Publication number	US-2025235521-A1
Application number	US-202318853887-A
Country	US
Kind code	A1
Filing date	Apr 5, 2023
Priority date	Apr 6, 2022
Publication date	Jul 24, 2025
Grant date	—

Abstract

The present invention provides Mycoplasma gallisepticum strain K6067 as deposited at the ATCC under Patent Designation PTA-127168, Mycoplasma gallisepticum strain K4110 as deposited at the ATCC under Patent Designation PTA-127282, and progeny and derivatives thereof, for use as a vaccine for the prevention of virulent Mycoplasma gallisepticum infections in the birds of the order Galliformes. Also provided are compositions and methods for administration to birds of the order Galliformes.

First claim

1 . An isolated Mycoplasma gallisepticum strain, wherein the isolated Mycoplasma gallisepticum strain comprises the K6067 Mycoplasma gallisepticum strain deposited at the ATCC under Patent Designation PTA-127168, or a progeny or derivative thereof, or comprises the K4110 Mycoplasma gallisepticum strain deposited at the ATCC under Patent Designation PTA-127282, and progeny and derivatives thereof.

2 - 3 . (canceled)

4 . A composition comprising the isolated Mycoplasma gallisepticum of claim 1 .

5 . The composition of claim 4 comprising water.

6 . The composition of claim 4 comprising a pharmaceutically acceptable carrier.

7 . The composition of claim 4 comprising an adjuvant.

8 . The composition of claim 4 , wherein the composition is formulated for intranasal, intraocular, oral, mucosal, intramuscular, subcutaneous, or in ovo administration.

9 . The composition of claim 4 , wherein the composition is formulated for spraying or aerosolizing.

10 . A vaccine comprising the isolated Mycoplasma gallisepticum of claim 1 .

11 . The vaccine of claim 10 , wherein the vaccine reduces one or more of the clinical signs induced by Mycoplasma gallisepticum infection in poultry.

12 . The vaccine of claim 10 , wherein the vaccine reduces the susceptibility of a birds of the order Galliformes to disease induced by Mycoplasma gallisepticum.

13 . A live vaccine for birds of the order Galliformes, the vaccine comprising an amount of the K6067 Mycoplasma gallisepticum strain deposited at the ATCC under Patent Deposit Designation PTA-127168 or a progeny or derivative thereof, or the K4110 Mycoplasma gallisepticum strain deposited at the ATCC under Patent Designation PTA-127282, and progeny and derivatives thereof sufficient to protect the birds from disease induced by Mycoplasma gallisepticum , and a pharmaceutically acceptable carrier.

14 . The vaccine of claim 10 , wherein the isolated Mycoplasma gallisepticum , composition, or vaccine is lyophilized, freeze dried, frozen, or an effervescent tablet.

15 . A kit comprising the isolated Mycoplasma gallisepticum of claim 1 and printed instructions, wherein the contents of the kit are contained within packaging material.

16 . A method of producing an immune response to Mycoplasma gallisepticum in a bird, the method comprising administering the isolated Mycoplasma gallisepticum of claim 1 to the bird.

17 . A method for reducing susceptibility of a bird against disease induced by Mycoplasma gallisepticum , the method comprising administering the isolated Mycoplasma gallisepticum of claim 1 to the bird.

18 . A method for protecting a bird against Mycoplasma gallisepticum infection, the method comprising administering the isolated Mycoplasma gallisepticum of claim 1 to the bird.

19 . A method of reducing one or more clinical signs induced by a Mycoplasma gallisepticum infection in a bird, the method comprising administering an effective amount of the isolated Mycoplasma gallisepticum of claim 1 to the bird.

20 . The method of claim 16 , wherein
administration is intranasal, intraocular, oral, mucosal, intramuscular, subcutaneous, or in ovo or by eye drop, by aerosol, or by drinking water.

21 . (canceled)

22 . The method of claim 16 , wherein the bird comprises a bird of the order Galliformes.

23 . The method of claim 16 , wherein the bird comprises a chicken or a turkey.

Assignees

• Univ Georgia

Inventors

• Ferguson-Noel Naola M

Classifications

• A61K2039/552

  Veterinary vaccine · CPC title

• A61K2039/542

  oral/gastrointestinal · CPC title

• A61K2039/522

  avirulent or attenuated · CPC title

• A61K9/0048

  Eye, e.g. artificial tears · CPC title

• C12N1/205 Primary

  Bacterial isolates · CPC title