Digital localized surface plasmon resonance sensor using bundle of optical fibers and fabrication method

Patent metadata

Field	Value
Publication number	US-2025231107-A1
Application number	US-202318853507-A
Country	US
Kind code	A1
Filing date	Mar 17, 2023
Priority date	May 26, 2022
Publication date	Jul 17, 2025
Grant date	—

Abstract

A digital localized surface plasmon resonance sensor using a bundle of optical fibers and a fabrication method. The digital localized surface plasmon resonance sensor can determine the sensor's output value by counting the number of optical fibers that output a signal greater than a certain size when the number of antigens bound to the antibody exceeds a predetermined number.

First claim

1 . A digital localized surface plasmon resonance (LSPR) sensor comprising:
an optical fiber bundle comprising a plurality of optical fibers, wherein a number of optical fibers is determined as an output value of the digital LSPR sensor, the optical fibers outputting a signal of a predetermined magnitude or more when a preset number of antigens are respectively bound to a plurality of antibodies present in the plurality of optical fibers.

2 . The digital LSPR sensor of claim 1 , wherein
an amino group is disposed on a cross-section of a core layer of each of the plurality of optical fibers, a metal material is connected to the amino group, and a plurality of antibodies capable of being bound to an antigen is connected to a surface of the metal material.

3 . The digital LSPR sensor of claim 1 , wherein
a digital value of 1 is determined for an optical fiber outputting a signal of a predetermined magnitude or more when a preset number or more of antigens are bound to the antibodies, and a digital value of 0 is determined for an optical fiber not outputting a signal of a predetermined magnitude or more when less than a preset number of antigens are bound to the antibodies.

4 . A digital localized surface plasmon resonance (LSPR) sensor comprising:
an optical fiber bundle comprising a plurality of optical fibers, wherein an output value of a sensor is determined based on a number of optical fibers outputting a signal of a predetermined magnitude or more when a preset number of antigens are bound to a plurality of first antibodies present in the plurality of optical fibers, and wherein the antigens are bound to a second antibody connected to a metal material.

5 . The digital LSPR sensor of claim 4 , wherein
the plurality of first antibodies is disposed on a cross-section of a core layer of each of the plurality of optical fibers, and the second antibody connected to the metal material is capable of being bound to the antigens bound to the plurality of first antibodies.

6 . The digital LSPR sensor of claim 4 , wherein
a digital value of 1 is determined for an optical fiber outputting a signal of a predetermined magnitude or more when a preset number or more of antigens are bound to the first antibodies, and a digital value of 0 is determined for an optical fiber not outputting a signal of a predetermined magnitude or more when less than a preset number of antigens are bound to the first antibodies.

7 . A method of fabricating a digital localized surface plasmon resonance (LSPR) sensor, the method comprising:
(i) configuring a plurality of optical fibers into a single optical fiber bundle; (ii) disposing an amino group on a cross-section of a core layer of each of the plurality of optical fibers; (iii) connecting a metal material to the amino group; and (iv) connecting, to a surface of the metal material, an antibody capable of being bound to an antigen.

8 . (canceled)

Assignees

• Univ Dankook Iacf

Inventors

• Lee Seung Ki
• Park Jae Hyoung
• Kim Hyeong Min
• Yang Seung Chul

Classifications

• G01N2021/772

  Tip coated light guide · CPC title

• G01N21/554 Primary

  detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance · CPC title

• G01N21/7703

  using reagent-clad optical fibres or optical waveguides (using measurement of total internal reflection or attenuated total reflection G01N21/552; optical fibres or waveguides per se G02B) · CPC title

• G01N33/543

  with an insoluble carrier for immobilising immunochemicals · CPC title

• G01N2201/08

  Optical fibres; light guides · CPC title