Emulsion for ultrasound ablation surgery

Patent metadata

Field	Value
Publication number	US-2025213733-A1
Application number	US-202519051906-A
Country	US
Kind code	A1
Filing date	Feb 12, 2025
Priority date	Jun 14, 2018
Publication date	Jul 3, 2025
Grant date	—

Abstract

The present description relates to an emulsion comprising an amphiphilic compound, a first phase comprising droplets including at least one perfluorocarbon compound and a second phase, which is aqueous. The droplets have a diameter d4,3 of between 0.5 pm and 5.5 pm, and the at least one perfluorocarbon compound has a boiling point above 100° C. The present description also relates to such an emulsion for use as an improving agent in ultrasound ablation surgery (FIG. 3).

First claim

What is claimed:

1 . A method for ultrasound ablation surgery, comprising:
administering an injectable emulsion by intravenous or intra-arterial injection or direct injection into a tissue to be treated; transmitting a focused ultrasound beam; and applying the focused ultrasound beam on at least one zone of the tissue; wherein the injectable emulsion comprises:
a first phase comprising droplets including at least one perfluorocarbon compound;
a second phase, which is aqueous; and
an amphiphilic compound;
wherein the droplets have a diameter d 4,3 of between 0.5 μm and 5.5 μm; and wherein the at least one perfluorocarbon compound has a boiling point above 100° C.

2 . The method of claim 1 , wherein the tissue to be treated belongs to one or more organs affected by cancer.

3 . The method of claim 1 , wherein the tissue to be treated belongs to an organ selected from the group consisting of the liver, spleen, kidneys, prostate, breasts and pancreas.

4 . The method of claim 1 , wherein the at least one zone of the tissue comprises focusing points of the focused ultrasound beam.

5 . The method of claim 1 , wherein transmitting is performed in pulsed mode and for a predetermined insonification time.

6 . The method of claim 5 , wherein applying is performed with a duty cycle corresponding to insonification of each focusing point of the at least one zone and comprised between 0 and 100%.

7 . The method of claim 1 , wherein the focused ultrasound beam has a frequency between 500 kHz and 2 MHz.

8 . The method of claim 1 , wherein the focused ultrasound beam has an intensity of between 0.05 W/cm 2 and 10,000 W/cm 2 .

9 . The method of claim 1 , wherein applying is performed on highly vascularized organs.

10 . The method of claim 1 , wherein the injectable emulsion further comprises a concentration by volume of the first phase in the second phase is between 0.001% v/v and 10% v/v.

11 . The method of claim 1 , wherein the at least one perfluorocarbon compound has a boiling point below 160° C.

12 . The method of claim 1 , wherein the at least one perfluorocarbon compound is selected from the group consisting of perfluorooctane, perfluorononane, perfluorodecalin, perfluorooctyl bromide (PFOB) and perfluoro-15-crown-5-ether (PFCE).

13 . The method of claim 1 , wherein the amphiphilic compound comprises a dendrimer of Dendri-TAC type or an oligomer of F i TAC n type.

14 . The method of claim 13 , wherein the amphiphilic compound is selected from the group consisting of F 6 TAC 7 , F 6 TAC 12 , F 6 TAC 29 , F 8 TAC 7 , F 8 TAC 13 , and F 8 TAC 17 .

Assignees

• Avignon Univ
• Centre Nat Rech Scient
• Inst Nat Sante Rech Med
• Univ Sorbonne
• Univ Montpellier
• Enscm

Inventors

• Contino-Pepin Christiane
• Desgranges Stéphane
• Taulier Nicolas

Classifications

• A61N7/00

  Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) · CPC title

• A61K49/10

  Organic compounds · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61K9/0009 Primary

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61K31/025

  carbocyclic · CPC title