Preparation and purification methods for mesenchymal stem cell derived secretome
US-2024091268-A1 · Mar 21, 2024 · US
US2025171171A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2025171171-A1 |
| Application number | US-202318730673-A |
| Country | US |
| Kind code | A1 |
| Filing date | Feb 3, 2023 |
| Priority date | Feb 4, 2022 |
| Publication date | May 29, 2025 |
| Grant date | — |
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A system for filling bags with a medical liquid is described. The system includes filling nozzles laterally mutually spaced from one another. The components of a medical liquid can be filled in a bag via one port each using the filling nozzles. A first filling nozzle is laterally movable with respect to at least one other filling nozzle.
Opening claim text (preview).
1 . A system for filling a bag with a medical liquid, the installation comprising: a first filing nozzle, wherein the first filing nozzle is configured to fill a first component of the medical liquid into the bag via a first port of the bag; and a second filling nozzle laterally spaced from the first filing nozzle, wherein the second filling nozzle is configured to fill a second component of the medical liquid into the bag via a second port of the bag, wherein the first filling nozzle is configured to be moved laterally relative to the second filling nozzle. 2 . The system of claim 1 , wherein the first filling nozzle is configured to be moved laterally using a drive. 3 . The system of claim 1 , further comprising a number of receptacles, wherein each of the receptacles is configured to receive a port of the bag, and wherein the number of receptacles is at least one greater than a number of filling nozzles. 4 . The system of claim 1 , wherein only the first filling nozzle is configured to be moved laterally. 5 . The system of claim 1 , wherein: the first filling nozzle is configured to be moved to at least two positions, the installation further comprises a plurality of receptacles, and each of the plurality of receptacles is arranged at one of the at least two positions. 6 . The system of claim 1 , wherein the installation further comprises a plurality of receptacles, and wherein each of the receptacles comprises a clamp for pressing a port of the bag closed. 7 . The system of claim 1 , wherein the filling is aseptic filling. 8 . The system of claim 1 , wherein the installation is a rotary installation. 9 . The system of claim 1 , wherein the first filling nozzle and the second filling nozzle are arranged on a head of the bag that is configured to be moved vertically relative to a plurality of receptacles of the installation. 10 . The system of claim 1 , wherein the installation is configured to fill at least three different bags that each have a different number of ports, and wherein the ports of each of the different bags are spaced apart from one another by different distances. 11 . Use of the system of claim 1 , for filling an infusion bag with a parenteral nutrition composition. 12 . A method for aseptically filling a bag with a medical liquid, the method comprising: providing the bag comprising a first port and a second port; laterally moving a first filling nozzle relative to a second filling nozzle to adjust the spacing between the first filling nozzle and the second filling nozzle to correspond to the spacing between the first port and the second port of the bag; filing a first component of the medical liquid into the bag using the first filing nozzle that is in fluid communication with the first port; and filing a second component of the medical liquid into the bag using the second filing nozzle that is in fluid communication with the second port. 13 . The method of claim 12 , wherein the bag defines a first chamber that is in fluid communication with the first port and a second chamber that is in fluid communication with the second port. 14 . The method of claim 12 , further comprising: flooding the bag with nitrogen before filling the first component of the medical liquid and filling the second component of the medical liquid; and/or gassing the first port and the second port with nitrogen during filling the first component of the medical liquid and filling the second component of the medical liquid. 15 . The method of claim 12 , further comprising closing the first port and the second port with a sealing element. 16 . The method of claim 15 , further comprising packaging the filled bag within a secondary package. 17 . The system of claim 1 , wherein the bag defines a first chamber that is in fluid communication with the first port and a second chamber that is in fluid communication with the second port. 18 . The system of claim 1 , further comprising a third filling nozzle laterally spaced apart from the first filling nozzle and the second filling nozzle. 19 . The system of claim 1 , further comprising a plurality of receptacles configured to be moved vertically relative to the first filling nozzle and the second filling nozzle arranged on a head of the bag. 20 . The system of claim 2 , The installation of claim 2 , wherein the drive is an electric drive, a pneumatic drive, or a hydraulic drive.
Multiple outlets · CPC title
movable towards or away from container or wrapper during filling or depositing · CPC title
for filling flexible containers having a filling and dispensing spout, e.g. containers of the "bag-in-box"-type · CPC title
Bag-type containers · CPC title
Containers having several compartments for products to be mixed · CPC title
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