Modular hemodialysis system

Patent metadata

Field	Value
Publication number	US-2025161543-A1
Application number	US-202519028634-A
Country	US
Kind code	A1
Filing date	Jan 17, 2025
Priority date	Aug 16, 2011
Publication date	May 22, 2025
Grant date	—

Abstract

Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.

First claim

What is claimed is:

1 . A system, comprising:
an extracorporeal module, an attachable urea removal module, and an attachable portable treatment module; the extracorporeal module having a blood pump that pumps blood from a subject through an extracorporeal circuit, the extracorporeal circuit having one or more attachments for fluidly connecting to a blood inlet and a blood outlet of a dialyzer; the dialyzer having a dialysis membrane where blood is conveyed from the subject to the dialyzer and back to the subject; and a single dialysate inlet and single dialysate outlet; wherein the portable treatment module is controlled compliant; and wherein the portable treatment module comprises a first dialysis circuit and a first dialysate pump for conveying a dialysate from the single dialysate outlet of the dialyzer and back to the single dialysate inlet of the dialyzer, wherein the portable treatment module has one or more attachments for connecting to a dialysate inlet and a dialysate outlet of the dialyzer; at least a first control pump in the portable treatment module for controlling a flux of fluid moving between the extracorporeal circuit and the portable treatment module by changing the rate at which the first control pump operates; the attachable urea removal module comprising a sorbent cartridge, a second dialysis circuit and a second dialysate pump for conveying a dialysate from the single dialysate outlet of the dialyzer and back to the single dialysate inlet of the dialyzer, wherein the attachable urea removal module has one or more attachments for connecting to a dialysate inlet and a dialysate outlet of the dialyzer; and a controller; the controller controlling the first control pump to achieve a set patient fluid removal rate and a set convective clearance.

2 . The system of claim 1 , with the proviso that the attachable portable treatment module does not contain a sorbent cartridge containing urease.

3 . The system of claim 1 , wherein the controller controls an efflux rate of the control pump based on the set convective clearance.

4 . The system of claim 3 , wherein the controller controls an inflex rate of the control pump based on the efflux rate and the set patient removal rate.

5 . The system of claim 4 , wherein the controller controls the control pump to operate in an efflux direction for a first set period of time and in an influx direction for a second set period of time.

6 . The system of claim 5 , wherein a ratio of the first and second set periods of time is set based on the set patient fluid removal rate and a set convective clearance.

7 . The system of claim 1 , wherein the sorbent cartridge in the attachable urea removal module contains urease and zirconium phosphate.

8 . The system of claim 1 , wherein the attachable urea removal module further comprises an infusate pump and an infusate reservoir.

9 . The system of claim 8 , wherein the infusate pump and infusate reservoir are connected to the second dialysis circuit downstream of the sorbent cartridge.

10 . The system of claim 1 , further comprising a second control pump in the portable treatment module for controlling a flux of fluid moving between the extracorporeal circuit and the portable treatment module by changing the rate at which the first control pump operates.

11 . The system of claim 10 , the controller controlling the first control pump and the second control pump to achieve the set patient fluid removal rate and the set convective clearance.

12 . The system of claim 11 , the controller controlling the first control pump to pump in an efflux direction and the second control pump to pump in an influx direction.

13 . The system of claim 12 , the controller controlling a ratio of the pump rates of the first control pump and second control pump to achieve the set patient fluid removal rate and the set convective clearance.

14 . The system of claim 1 , further comprising a hematocrit or a hemoglobin detector.

15 . The system of claim 1 , the controller adjusting the set patient fluid removal rate based on a hematocrit level of the patient.

16 . The system of claim 1 , further comprising at least a second control pump in the attachable urea removal module.

17 . The system of claim 1 , wherein the portable treatment module comprises a sorbent cartridge containing activated carbon.

18 . The system of claim 17 , wherein the sorbent cartridge in the portable treatment module contains zirconium oxide.

19 . The system of claim 17 , with the proviso that the sorbent cartridge in the portable treatment module does not contain urease or zirconium phosphate.

20 . The system of claim 1 , wherein the attachable urea removal module comprises a conductivity sensor in the second dialysis circuit.

Assignees

• Mozarc Medical Us Llc

Inventors

• Kelly Thomas D
• Lyu Suping
• Pudil Bryant J
• Meyer Thomas E

Classifications

• A61M2230/207

  hematocrit · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M2205/3317

  Electromagnetic, inductive or dielectric measuring means · CPC title

• A61M2205/3324

  PH measuring means · CPC title

• A61M1/1609

  after use, i.e. downstream of dialyser · CPC title