Method for predicting whole blood platelet count

Patent metadata

Field	Value
Publication number	US-2025161542-A1
Application number	US-202418955258-A
Country	US
Kind code	A1
Filing date	Nov 21, 2024
Priority date	Nov 22, 2023
Publication date	May 22, 2025
Grant date	—

Abstract

Blood processing systems, devices, and methods including a durable hardware component, a single use fluid flow circuit, and a controller configured to estimate the concentration of platelets in a donor's circulating blood.

First claim

1 . A system for collecting platelets comprising:
a reusable hardware unit, wherein the reusable hardware unit comprises a separator; a disposable fluid circuit configured to be associated with the reusable hardware unit; and a controller configured to estimate a platelet concentration of a donor's circulating blood (C donor ).

2 . The system of claim 1 , wherein C donor is based on a concentration of platelets in collected whole blood entering the separator (C wbcent ) and a percentage of collected whole blood in a separator inlet line (WB %).

3 . The system of claim 2 , wherein C donor is obtained by determining a product of the concentration of platelets in collected whole blood entering the separator (C wbcent ) and the percentage of collected whole blood in a separator inlet line (WB %), such that:

C

d
⁢
o
⁢
n
⁢
o
⁢
r

=

C
wbcent

⁢
W
⁢
B
⁢

%
.

4 . The system of claim 2 , wherein the WB % is obtained by dividing an amount of collected whole blood in the separator inlet line with a total amount of collected whole blood and other fluid in the separator inlet line.

5 . (canceled)

6 . The system of claim 4 , wherein the WB % is obtained by dividing parts of collected whole blood with a sum of the parts of collected whole blood (Parts WB) and parts of anticoagulant, such that:

W
⁢
B
⁢

%

=

Parts
⁢

W
⁢
B
/

(

Parts
⁢

W
⁢
B

+

Parts
⁢

Anticoagulant

)

.

7 . The system of claim 2 , wherein C wbcent is based on a platelet concentration of separated platelet rich plasma (C prp ) and a hematocrit of collected whole blood entering the separator (H wbcent ).

8 . (canceled)

9 . The system of claim 7 , wherein C wbcent is determined by an equation:

C
wbcent

=

C
prp

*

(

1
-

H

w
⁢
b
⁢
c
⁢
e
⁢
n
⁢
t

)

.

10 . The system of claim 7 , wherein H wbcent is based on a flow rate of separated packed red blood cells exiting the separator (Q rbc ), a flow rate of collected whole blood flowing into the separator (Q wbcent ), and a hematocrit of the separated packed red blood cells exiting the separator (H rbc ).

11 . The system of claim 10 , wherein H wbcent is determined by dividing a product of H rbc and Q rbc with Q wbcent , such that:

H
wbcent

=

(

H
rbc

*

Q
rbc

)

/

Q
wbcent

.

12 . The system of claim 10 , wherein Q rbc is based on the flow rate of collected whole blood flowing into the separator (Q wbcent ) and a flow rate of separated platelet rich plasma flowing out of the separator (Q prp ), wherein Q rbc is determined by subtracting Q prp from Q wbcent such that: Q rbc =Q wbcent −Q prp .

13 . The system of claim 12 , wherein Q wbcent is based on a pump rate of a separator pump and Q prp is based on a pump rate of a platelet rich plasma pump.

14 . (canceled)

15 . (canceled)

16 . The system of claim 10 , wherein H rbc is a predetermined value.

17 . The system of claim 10 , wherein H rbc is determined by an optical sensor or based on separator flow rates and separator q-force.

18 . (canceled)

19 . The system of claim 11 , wherein the controller is configured to determine C wbcent , WB %, C prp , H wbcent , H rbc , and Q rbc .

20 . The system of claim 2 , wherein the controller is configured to estimate the platelet concentration of a donor's circulating blood (C donor ) with an equation:

C
donor

=

(

C
prp

*
W
⁢
B
⁢

%

)

*

(

1
-

(

H

Assignees

• Fenwal Inc

Inventors

• Kusters Benjamin E
• Min Kyungyoon

Classifications

• A61M2205/3393

  by weighing the reservoir · CPC title

• A61M2205/3355

  Controlling downstream pump pressure · CPC title

• A61M2205/3351

  Controlling upstream pump pressure · CPC title

• A61M2205/3344

  Measuring or controlling pressure at the body treatment site · CPC title

• A61M2205/331

  used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection · CPC title