Control of a machine for peritoneal dialysis

Patent metadata

Field	Value
Publication number	US-2025152794-A1
Application number	US-202318839371-A
Country	US
Kind code	A1
Filing date	Mar 7, 2023
Priority date	Mar 9, 2022
Publication date	May 15, 2025
Grant date	—

Abstract

A control device performs a method to generate control signals for a dialysis machine, which is configured to perform peritoneal dialysis, PD, treatment comprising one or more fluid exchange cycles in relation to a peritoneal cavity of a patient, to cause a transport of fluid and solutes through its peritoneal membrane. The method comprises: obtaining a target value of a treatment parameter for the PD treatment, obtaining a transport property of the peritoneal membrane, and configuring a transport model by use of the at least one transport property. The transport model defines the transport of fluid and solutes through the peritoneal membrane as a function of control parameters for the PD treatment. The method further comprises: evaluating the transport model to determine set values of the control parameters to achieve the target value, and generating the control signals in correspondence with the set values.

First claim

1 - 39 . (canceled)

40 . A control device for operating a dialysis machine to perform a peritoneal dialysis treatment in relation to a patient, the dialysis machine being operable, based on control signals from the control device, to perform one or more fluid exchange cycles in relation to a peritoneal cavity of the patient to cause a transport of fluid and solutes through a peritoneal membrane in the peritoneal cavity, the control device comprising control circuitry configured to:
obtain a target value of a treatment parameter for the peritoneal dialysis treatment; obtain at least one transport property of the peritoneal membrane of the patient; configure a transport model by use of the at least one transport property, the transport model defining the transport of fluid and solutes through the peritoneal membrane as a function of a plurality of control parameters for the peritoneal dialysis treatment performed by the dialysis machine; evaluate the transport model to determine set values of the plurality of control parameters to achieve the target value; and generate control signals for the dialysis machine in correspondence with the set values, the control signals causing the dialysis machine to perform the peritoneal dialysis treatment, wherein the control circuitry is further configured to: obtain first data comprising a measured value of a concentration-related parameter of fluid in the peritoneal cavity at one or more time points during the peritoneal dialysis treatment; obtain second data indicative of fluid flow of treatment fluid into and/or out of the peritoneal cavity during the peritoneal dialysis treatment; and calculate, by use of the transport model and based on the first data and the second data, at least one updated transport property of the peritoneal membrane of the patient.

41 . The control device of claim 40 , wherein the control circuitry is further configured to reconfigure the transport model by the at least one updated transport property to generate a reconfigured transport model.

42 . The control device of claim 41 , wherein the control circuitry is further configured to: evaluate the reconfigured transport model to determine updated set values of the plurality of control parameters to achieve the target value, and generate updated control signals for the dialysis machine in correspondence with the updated set values.

43 . The control device of claim 41 , wherein the control circuitry is further configured to present the at least one updated transport property on a user interface of the dialysis machine and/or store the at least one updated transport property in a memory associated with the control device.

44 . The control device of claim 41 , wherein the control circuitry is further configured to:
calculate a final value of the treatment parameter by use of the reconfigured transport model and based on the second data; and present the final value on a user interface of the dialysis machine and/or store the final value in a memory associated with the control device.

45 . The control device of claim 40 , wherein the control circuitry is further configured to:
calculate, by use of the transport model and based on the first data and/or the second data, an expected value of an evaluation parameter for the fluid in the peritoneal cavity; determine a first deviation between the expected value and a corresponding value given by the first data or the second data; and selectively, based on the first deviation, calculate the at least one updated transport property of the peritoneal membrane of the patient.

46 . The control device of claim 45 , wherein the control circuitry is configured to calculate, based on the second data, the expected value to represent the concentration-related parameter of fluid in the peritoneal cavity at the one or more time points during the peritoneal dialysis treatment, and determine the first deviation between the expected value and the measured value in the first data.

47 . The control device of claim 45 , wherein the control circuitry is configured to:
refrain from calculating the at least one updated transport property when the first deviation is between a first positive limit and a first negative limit; calculate the at least one updated transport property when the first deviation is larger than the first positive limit or smaller than the first negative limit; and generate an alert for an operator of the dialysis machine when the first deviation is larger than a second positive limit, which is larger than the first positive limit, or smaller than a second negative limit, which is smaller than the first negative limit.

48 . The control device of claim 47 , wherein the control circuitry is configured to, over time during the peritoneal dialysis treatment, perform at least one of: decreasing a first difference between the first positive limit and the first negative limit, or decreasing a second difference between the second positive limit and the second negative limit.

49 . The control device of claim 48 , wherein the control circuitry is configured to:
reconfigure the transport model by the at least one updated transport property to generate a reconfigured transport model and calculate, by use of the reconfigured transport model, a final value of the treatment parameter; determine a second deviation between the final value and the target value; and selectively, based on the second deviation, evaluate the reconfigured transport model to determine updated set values of the plurality of control parameters to achieve the target value, and generate updated control signals for the dialysis machine in correspondence with the updated set values.

50 . The control device of claim 40 , wherein the control circuitry, when evaluating the transport model, is further configured to, repeatedly:
calculate, by use of the transport model, time-resolved values of fluid volume and solute concentration in the peritoneal cavity for candidate set values of the plurality of control parameters; calculate a resulting value of the treatment parameter based on the time-resolved values of fluid volume and solute concentration; and modify one or more of the candidate set values until the resulting value fulfils a termination criterion or a time limit is reached.

51 . The control device of claim 50 , wherein the control circuitry is configured to designate a first subset of the candidate set values as modifiable and a second subset of the candidate set values as fixed, and wherein the one or more of the candidate values is included in the first subset.

52 . The control device of claim 50 , wherein the control circuitry is configured to: obtain a respective allowable range of the one or more of the candidate set values; and modify the one or more of the candidate set values within the respective allowable range.

53 . The control device of claim 40 , wherein the plurality of control parameters comprises: a composition of a treatment fluid supplied to the peritoneal cavity during the peritoneal dialysis treatment, a number of fluid exchange cycles to be performed during the peritoneal dialysis treatment, an amount of treatment fluid supplied to the peritoneal cavity in a respective fluid exchange cycle during the peritoneal dialysis treatment, and a duration of the peritoneal dialysis treatment.

54 . The control device of claim 40 , wherein the treatment parameter represents an accumulated amount of fluid removed from the patient during the peritoneal dialysis treatment, or an accumulated amount of one or more solutes removed from the patient durin

Assignees

• Gambro Lundia Ab

Inventors

• Borgqvist Per-Olof
• Holmer Mattias
• Bergling Karin

Classifications

• A61M2205/52

  with memories providing a history of measured variating parameters of apparatus or patient · CPC title

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61M2205/3379

  Masses, volumes, levels of fluids in reservoirs, flow rates · CPC title

• A61M2205/3331

  Pressure; Flow · CPC title

• A61M2205/3327

  Measuring · CPC title