Bioabsorbable and photocurable composition, bioabsorbable guided tissue regeneration composition, and grafting method using same

Patent metadata

Field	Value
Publication number	US-2025134667-A1
Application number	US-202318836830-A
Country	US
Kind code	A1
Filing date	Feb 14, 2023
Priority date	Feb 15, 2022
Publication date	May 1, 2025
Grant date	—

Abstract

A bioabsorbable and photocurable composition, a bioabsorbable guided tissue regeneration composition, and a grafting method using same are provided. The bioabsorbable and photocurable composition includes a photosensitizer and collagen, and is applied onto an in vivo graft site filled with a graft material, so as to cover the graft material while filling an empty space of the graft site, and the photosensitizer is activated by the irradiation of visible light so that the collagen is cross-linked, and the collagen cross-linked by the visible light fills the minute empty space of the graft site and closely binds the graft material to fix the graft material.

First claim

1 . A bioabsorbable and photocurable composition, comprising
a photosensitizer and collagen, wherein the bioabsorbable and photocurable composition is applied onto an in vivo graft site filled with a graft material, so as to cover the graft material while filling an empty space of the graft site, and the photosensitizer is activated by the irradiation of visible light so that the collagen is cross-linked, and the collagen cross-linked by the visible light fills the minute empty space of the graft site and closely binds the graft material to fix the graft material.

2 . The bioabsorbable and photocurable composition of claim 1 , wherein
a viscosity of the photocurable composition after irradiation of visible light increases by 1.5 to 4.5 times compared to before irradiation of visible light.

3 . The bioabsorbable and photocurable composition of claim 1 , wherein
the photosensitizer is riboflavin.

4 . The bioabsorbable and photocurable composition of claim 3 , wherein
a weight ratio of the riboflavin:collagen is 1:0.00056 to 1:0533.

5 . The bioabsorbable and photocurable composition of claim 3 , wherein
the visible light is a light source in a blue wavelength range and has a maximum output of 2 W/cm 2 .

6 . A bioabsorbable guided tissue regeneration composition, comprising
a graft material including a first agent including collagen as a main ingredient and a second agent including a peptide formulated to be immersed in the first agent; and a bioabsorbable and photocurable composition including a photosensitizer and collagen, wherein the bioabsorbable and photocurable composition is applied to an graft site filled with a graft material so as to cover the graft material while filling an empty space of the graft site, and the photosensitizer is activated by the irradiation of visible light so that the collagen is cross-linked, and the collagen cross-linked by the visible light fills the fine empty space of the graft site and closely binds the graft material to fix the graft material.

7 . The bioabsorbable guided tissue regeneration composition of claim 6 , wherein
the peptide has antibacterial activity, anti-inflammatory activity, antibacterial activity and anti-inflammatory activity, antibacterial activity, anti-inflammatory activity, and cell-penetrating properties.

8 . The bioabsorbable guided tissue regeneration composition of claim 7 , wherein
the peptide is represented by any one of the amino acid sequences of SEQ ID NOs: 1 to 5.

9 . The bioabsorbable guided tissue regeneration composition of claim 7 , wherein
the graft material includes 10 −4 to 0.5 parts by weight of the peptide.

10 . The bioabsorbable guided tissue regeneration composition of claim 6 , wherein
a viscosity of the photocurable composition after irradiation of visible light increases by 1.5 to 4.5 times compared to before irradiation of visible light.

11 . The bioabsorbable guided tissue regeneration composition of claim 6 , wherein
the photosensitizer is riboflavin.

12 . The bioabsorbable guided tissue regeneration composition of claim 11 , wherein
a weight ratio of the riboflavin:collagen is 1:0.00056 to 1:0.0533.

13 . The bioabsorbable guided tissue regeneration composition of claim 6 , wherein
the visible light is a light source in a blue wavelength range and has a maximum output of 2 W/cm 2 .

14 . A grafting method, comprising
filling a vivo graft site with a graft material; applying a bioabsorbable and photocurable composition including a photosensitizer and collagen onto the graft site filled with the graft material, thereby filling the empty space of the graft site and covering the graft material; and irradiating visible light to the bioabsorbable and photocurable composition to activate the photosensitizer and cross-link the collagen, so that the collagen cross-linked by the visible light fills the fine empty space of the graft site and closely binds the graft material to fix the graft material.

15 . The grafting method of claim 14 , wherein
before filling the graft material, pretreating the vivo graft site is further included.

16 . The grafting method of claim 15 , wherein
the graft site is a periodontal disease site, the pretreating includes scaling or scaling and root planing.

17 . The grafting method of claim 14 , wherein
a viscosity of the photocurable composition after irradiation of visible light increases by 1.5 to 4.5 times compared to before irradiation of visible light.

18 . The grafting method of claim 14 , wherein
the photosensitizer is riboflavin.

19 . The grafting method of claim 18 , wherein
a weight ratio of the riboflavin:collagen is 1:0.00056 to 1:0.0533.

20 . The grafting method of claim 14 , wherein
the visible light is a light source in a blue wavelength range and has a maximum output of 2 W/cm 2 .

21 . The grafting method of claim 14 , wherein
a light irradiator that irradiates visible light penetrates into the bioabsorbable and photosensitive composition and delivers the light source.

22 . The grafting method of claim 14 , wherein
a first agent including collagen as a main ingredient and a second agent including a peptide formulated to be immersed in the first agent.

23 . The grafting method of claim 22 , wherein
the peptide has antibacterial activity, anti-inflammatory activity, antibacterial activity and anti-inflammatory activity, antibacterial activity, anti-inflammatory activity, and cell-penetrating properties.

24 . The grafting method of claim 23 , wherein
the peptide is represented by any one of the amino acid sequences of SEQ ID NOs: 1 to 5.

25 . The grafting method of claim 23 , wherein
the graft material includes 10 −4 to 0.5 parts by weight of the peptide.

Assignees

• Nibec Co Ltd
• Seoul Nat Univ R&Db Foundation

Inventors

• Park Yoon Jeong
• Chung Chong-Pyoung
• Seol Yang-Jo
• Lee Jue-Yeon
• Jo Beom Soo

Classifications

• A61L2400/06

  Flowable or injectable implant compositions · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title

• A61L2430/12

  for dental implants or prostheses · CPC title

• A61L2300/41

  Anti-inflammatory agents, e.g. NSAIDs · CPC title

• A61L2300/404

  Biocides, antimicrobial agents, antiseptic agents · CPC title