Anti-infection fluidic channel

Patent metadata

Field	Value
Publication number	US-2025128021-A1
Application number	US-202419005983-A
Country	US
Kind code	A1
Filing date	Dec 30, 2024
Priority date	Mar 13, 2023
Publication date	Apr 24, 2025
Grant date	—

Abstract

Systems and methods for altering the geometry of a fluid channel to prevent upstream mobility of bacteria, using angled obstacles on the interior of the channel that among other things creates vortices that restrict the mobility. An optimized geometry can be realized by an artificial intelligence algorithm or similar methods based on performance of various configurations of obstacle parameters.

First claim

The following are claimed:

1 . A catheter having a urine flow direction, the catheter comprising:
a plurality of protuberances on an interior surface of the catheter, each of the protuberances having a first side facing into the flow direction at a first angle from the interior surface and a second side facing away from the flow direction at a second angle from the interior surface and a vertex between the first side and the second side and a base length from where the first side connects to the interior surface to where the second side connects to the interior surface, each of the plurality of protuberances being configured to create vortices during a flow of fluid in the urine flow direction; the first angle being different from the second angle, such that each protuberance has an asymmetrical profile and wherein the first angle is greater than 90 degrees and the second angle is less than 90 degrees; and the base length of each of the plurality of protuberances being less than one half the distance between vertices of adjacent protuberances.

2 . The catheter of claim 1 , wherein the catheter has an outer diameter from 5 to 36 Fr.

3 . The catheter of claim 1 , wherein catheter has a channel width from 1 to 100 mm.

4 . The catheter of claim 3 , wherein each of the plurality of protuberances has a height equal to or less than 30% of the channel width.

5 . The catheter of claim 1 , wherein the plurality of protuberances is composed of silicone rubber, nylon, polyurethane, polyethylene terephthalate, latex, polytetrafluoroethylene, or combinations thereof.

6 . The catheter of claim 1 , wherein the catheter has an inner diameter between 1 and 5 mm, the plurality of protuberances have a base-to-base inter-obstacle distance (d) greater than 20 um, and each of the plurality of protuberances has a base width (L) greater than 2 um, a height (h) greater than 5 um and less than half the inner diameter, and an s-parameter greater than a width of a base of each of the plurality of protuberances and less than half of the base-to-base inter-obstacle distance.

7 . A method of making a catheter having a urine flow direction, the method comprising:
providing a catheter tube with an inner channel; providing a plurality of protuberances on an interior surface of the inner channel, each of the protuberances having a first side facing into the flow direction at a first angle from the interior surface and a second side facing away from the flow direction at a second angle from the interior surface and a vertex between the first side and the second side and a base length from where the first side connects to the interior surface to where the second side connects to the interior surface, each of the plurality of protuberances being configured to create vortices during a flow of fluid in the urine flow direction; the first angle being different from the second angle, such that each protuberance has an asymmetrical profile and wherein the first angle is greater than 90 degrees and the second angle is less than 90 degrees; and the base length of each of the plurality of protuberances being less than one half the distance between vertices of adjacent protuberances.

8 . The method of claim 7 , wherein the catheter has an outer diameter from 5 to 36 Fr.

9 . The method of claim 7 , wherein catheter has a channel width from 1 to 100 mm.

10 . The method of claim 9 , wherein each of the plurality of protuberances has a height equal to or less than 30% of the channel width.

11 . The method of claim 7 , wherein the providing the plurality of protuberances comprises one or more of: 3D printing, injection molding, extrusion molding, computer numerical control machining, polymer casting, and thermoforming.

12 . The method of claim 7 , wherein the plurality of protuberances is composed of silicone rubber, nylon, polyurethane, polyethylene terephthalate, latex, polytetrafluoroethylene, or combinations thereof.

Assignees

• California Inst Of Techn

Inventors

• Zhou Tingtao
• Wan Xuan
• Sternberg Paul W
• Daraio Chiara
• Huang Zhengyu
• Li Zongyi
• Peng Zhiwei
• Brady John F
• Anandkumar Animashree

Classifications

• G06N20/00

  Machine learning · CPC title

• A61M2025/006

  having a special surface topography or special surface properties, e.g. roughened or knurled surface · CPC title

• G16H50/50

  for simulation or modelling of medical disorders · CPC title

• G16H30/40

  for processing medical images, e.g. editing · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title