Antimicrobial layered material

Patent metadata

Field	Value
Publication number	US-2025120395-A1
Application number	US-202418991014-A
Country	US
Kind code	A1
Filing date	Dec 20, 2024
Priority date	Dec 19, 2017
Publication date	Apr 17, 2025
Grant date	—

Abstract

The invention relates to an antimicrobial layer material comprising a layer with a particulate biocidal active ingredient and, on top of that, a layer as transport control layer, wherein the transport control layer is depositable or has been deposited in an afterglow PE-CVD method. The invention further relates to a substrate coated with such an antimicrobial layer material, to the use of a plasma-polymeric layer deposited in an afterglow PE-CVD method as transport control layer for a particulate biocidal active ingredient, and to a method of producing an antimicrobial layer material and to a method of producing a substrate comprising an antimicrobial layer material.

First claim

1 . An antimicrobial layer material comprising:
a biocide layer with a particulate biocidal active ingredient; and a plasma-polymeric layer as a transport control layer disposed upon the biocide layer,; wherein the antimicrobial layer material includes the biocide layer including a sputtered metallic silver layer having a plurality of silver particles, wherein for over 95% of the plurality of particles, each of the plurality of particles has a limiting size of ≤80 nm, and the plasma-polymeric layer including the transport control layer disposed thereon, the transport control layer having a thickness in a range of ≥5 nm and ≤320 nm, and a ratio of a thickness of the transport control layer to the limiting size of ≥1.4; wherein the transport control layer has a layer construction characterized by a particle release rate correlated with a decolorization time of ≤25 minutes per a thickness of the transport control layer of 40 nm when a sample including the antimicrobial layer disposed on a substrate is subjected to a H 2 O 2 treatment including covering the transport control layer of the sample with at least 1 cm 3 of 50% H 2 O 2 solution at 25° C. per cm 2 of the transport control layer; wherein the decolorization time corresponds to a time duration required for an absorption constant of the sample in a wavelength range of 300 nm to 500 nm to have a differential of 0.01 relative to a reference sample including the substrate and the plasma-polymeric layer deposited directly on the substrate without the biocide layer; wherein the particulate biocidal active ingredient is selected from the group consisting of silver, copper, and zinc; and wherein the plasma-polymeric layer consists of at least 95 atom % of elements being selected from a group of elements consisting of Ti, O and C; Si, O, C and N; and Si, O and C, based on a total number of atoms determined by XPS.

2 - 5 . (canceled)

6 . The antimicrobial layer material as claimed in claim 1 , wherein a concentration of the particulate biocidal active ingredient is 0.3-10 μg/cm 2 .

7 - 9 . (canceled)

10 . The antimicrobial layer material as claimed in claim 1 , wherein a layer is provided on a side of the biocide layer remote from the transport control layer.

11 . A substrate comprising the antimicrobial layer material as claimed in claim 1 .

12 . The substrate as claimed in claim 11 , wherein the substrate comprises a product selected from the group consisting of a product for human application, a product for veterinary application, and a combination of the two aforementioned.

13 . A method of use of the plasma-polymeric layer as claimed in claim 1 as the transport control layer for the particulate biocidal active ingredient.

14 . A method of producing the antimicrobial layer material as claimed in claim 1 , comprising the steps of:
a) depositing the particulate biocidal layer; and b) after step a), depositing the plasma-polymeric transport control layer in a plasma enhanced-chemical vapor deposition (PE-CVD) method.

15 . A method of producing a substrate comprising the antimicrobial layer material as claimed in claim 1 , comprising the steps of:
a) providing the substrate; and b) depositing the antimicrobial layer material onto the substrate.

16 . The antimicrobial layer as claimed in claim 1 , wherein the particulate biocidal active ingredient is an organic biocide.

17 . The substrate as claimed in claim 11 , wherein the substrate comprises a product selected from the group consisting of an implant, a wound dressing, hygiene product and a packaging material.

18 . The substrate as claimed in claim 11 , wherein the substrate comprises a medical product.

19 . The method of claim 7 , wherein the step of depositing the antimicrobial layer material onto the substrate is conducted in at a pressure in a range of 0.02 mbar to 0.025 mbar.

Assignees

• Fraunhofer Ges Forschung
• Bio Gate Ag

Inventors

• Vissing Klaus-Dieter
• Salz Dirk
• Steinrücke Peter

Classifications

• A01N59/16

  Heavy metals; Compounds thereof · CPC title

• A01N59/20

  Copper · CPC title

• C09D5/14

  Paints containing biocides, e.g. fungicides, insecticides or pesticides (C09D5/16 takes precedence) · CPC title

• A01N25/34 Primary

  Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group · CPC title