Neurostimulation waveforms having a base component and a high frequency component, and associated systems and methods

Patent metadata

Field	Value
Publication number	US-2025099767-A1
Application number	US-202418906025-A
Country	US
Kind code	A1
Filing date	Oct 3, 2024
Priority date	Jun 11, 2021
Publication date	Mar 27, 2025
Grant date	—

Abstract

The present technology provides systems and methods for directly suppressing nerve cells by delivering electrical stimulation having relatively long pulse widths and at amplitudes below an activation threshold of the nerve cells. For example, some embodiments include delivering a therapy signal having individual pulses with pulse widths of between about 5 ms and 100 ms. Directly suppressing the nerve cells is expected to reduce the transmission of pain signals.

First claim

1 - 68 . (canceled)

69 . A patient treatment system, comprising:
a signal generator having a computer readable storage medium with instructions that, in operation, generate a therapy signal having a base component and a high frequency component, wherein—
the base component has pulses with a non-zero amplitude, and
the high frequency component includes high frequency pulses having a frequency in a frequency range of from about 1.2 kHz to about 100 kHz, wherein the high frequency pulses have an origin at the non-zero amplitude of the base component; and
a signal delivery element coupleable to the signal generator, wherein the signal delivery element is positionable proximate a spinal cord region, and, in operation, delivers the therapy signal to the spinal cord region.

70 . The patient treatment system of claim 69 wherein the base component pulses include biphasic pulses having an anodic pulse phase and a cathodic pulse phase, and wherein the high frequency pulses occur during the anodic pulse phase and/or the cathodic pulse phase.

71 . The patient treatment system of claim 70 wherein the high frequency pulses occur during only one of the anodic pulse phase or the cathodic pulse phase.

72 . The patient treatment system of claim 70 wherein the high frequency pulses occur during both the anodic pulse phase and the cathodic pulse phase.

73 . The patient treatment system of claim 70 wherein adjacent biphasic pulses of the biphasic pulses of the base component pulses are separated by an interpulse interval, and wherein the high frequency pulses do not occur during the interpulse interval.

74 . The patient treatment system of claim 70 wherein the base component pulses include an interphase interval between the anodic pulse phase and the cathodic pulse phase, and wherein the high frequency pulses do not occur during the interphase interval.

75 . The patient treatment system of claim 69 wherein the base component pulses include monophasic pulses having the non-zero amplitude.

76 . The patient treatment system of claim 69 wherein at least two high frequency pulses originate from each base component pulse.

77 . The patient treatment system of claim 69 wherein the high frequency pulses have an amplitude greater than the non-zero amplitude of the base component pulses.

78 . The patient treatment system of claim 69 wherein the frequency range is from about 5 kHz to about 25 kHz.

79 . A method for treating a patient, comprising:
programming a signal generator to deliver a therapy signal to a target neural population in the patient's spinal cord region via at least one implanted signal delivery element, wherein the therapy signal includes (i) a base component having pulses with a non-zero amplitude, and (ii) a high frequency component including high frequency pulses having a frequency in a frequency range of from about 1.2 kHz to about 100 kHz, wherein the high frequency pulses have an origin at the non-zero amplitude of the base component.

80 . The method of claim 79 wherein the therapy signal at least partially suppresses at least a subset of neurons in the spinal cord region, and wherein the subset of neurons includes WDR neurons and/or NS neurons.

81 . The method of claim 79 wherein the base component pulses include biphasic pulses having an anodic pulse phase and a cathodic pulse phase, and wherein the high frequency pulses occur during the anodic pulse phase and/or the cathodic pulse phase.

82 . The method of claim 81 wherein the high frequency pulses occur during only one of the anodic pulse phase or the cathodic pulse phase.

83 . The method of claim 81 wherein the high frequency pulses occur during both the anodic pulse phase and the cathodic pulse phase.

84 . The method of claim 79 wherein the base component pulses include a plurality of monophasic pulses having the non-zero amplitude.

85 . The method of claim 79 wherein at least two high frequency pulses originate from each base component pulse.

86 . The method of claim 79 wherein the high frequency pulses include bursts of high frequency pulses.

87 . The method of claim 86 wherein each base component pulse includes at least two bursts of high frequency pulses separated by a quiescent period having no high frequency pulses.

88 . The method of claim 79 wherein the frequency range is from about 3 kHz to about 50 kHz.

89 . A method for treating a patient, comprising:
applying a therapy signal to the patient via a treatment system, wherein the treatment system includes a signal delivery element positioned proximate a spinal cord region of the patient, and wherein the therapy signal includes (i) a base component having pulses with a non-zero amplitude, and (ii) a high frequency component including high frequency pulses having a frequency in a frequency range of from about 1.2 kHz to about 100 kHz, wherein the high frequency pulses have an origin at the non-zero amplitude of the base component.

90 . The method of claim 89 wherein the base component pulses include biphasic pulses having an anodic pulse phase and a cathodic pulse phase, and wherein the high frequency pulses occur during the anodic pulse phase and/or the cathodic pulse phase.

91 . The method of claim 89 wherein the base component pulses include a plurality of monophasic pulses having the non-zero amplitude.

92 . The method of claim 89 wherein at least two high frequency pulses originate from each base component pulse.

93 . The method of claim 89 wherein the therapy signal at least partially suppresses at least a subset of neurons in the spinal cord region, and wherein the subset of neurons includes WDR neurons and/or NS neurons.

Assignees

• Nevro Corp

Inventors

• Lee Dongchul
• Bradley Kerry

Classifications

• A61N1/36171

  Frequency · CPC title

• A61N1/36062

  Spinal stimulation · CPC title

• A61N1/36175

  Pulse width or duty cycle · CPC title

• A61N1/0551 Primary

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/36071 Primary

  Pain · CPC title