Method for storing reduced coenzyme q10

Patent metadata

Field	Value
Publication number	US-2025082585-A1
Application number	US-202218723030-A
Country	US
Kind code	A1
Filing date	Dec 21, 2022
Priority date	Dec 24, 2021
Publication date	Mar 13, 2025
Grant date	—

Abstract

The present description discloses a preferred solution for controlling oxidation of reduced coenzyme Q10 (QH) without any need for formulation of QH. One or more embodiments of the present invention relate to a method for storing QH, including storing a composition containing solid QH and water, a method for controlling oxidation of QH, including storing a composition containing solid QH and water, and a liquid composition containing solid QH in water. The solid QH is preferably one or more selected from the group consisting of a Form I crystal, a Form II crystal, an amorphous solid, and a co-crystal composed of QH and one or more other compounds.

First claim

1 . A method for storing reduced coenzyme Q10, comprising storing a composition comprising solid reduced coenzyme Q10 and water.

2 . The method according to claim 1 , wherein the solid reduced coenzyme Q10 is one or more selected from the group consisting of a reduced coenzyme Q10 Form I crystal, a reduced coenzyme Q10 Form II crystal, a co-crystal comprising reduced coenzyme Q10 and one or more other compounds, and an amorphous solid of reduced coenzyme Q10.

3 . The method according to claim 1 , wherein the composition is a liquid composition comprising the solid reduced coenzyme Q10 in water or a solid composition comprising the solid reduced coenzyme Q10 wetted with water.

4 . A method for controlling oxidation of reduced coenzyme Q10, comprising
storing a composition comprising solid reduced coenzyme Q10 and water.

5 . The method according to claim 4 , wherein the solid reduced coenzyme Q10 is one or more selected from the group consisting of a reduced coenzyme Q10 Form I crystal, a reduced coenzyme Q10 Form II crystal, a co-crystal comprising reduced coenzyme Q10 and one or more other compounds, and an amorphous solid of reduced coenzyme Q10.

6 . The method according to claim 4 , wherein the composition is a liquid composition comprising the solid reduced coenzyme Q10 in water or a solid composition comprising the solid reduced coenzyme Q10 wetted with water.

7 . A liquid composition comprising solid reduced coenzyme Q10 and water.

8 . The liquid composition according to claim 7 , comprising 10 parts by mass or more of water based on 1 part by mass of the solid reduced coenzyme Q10.

9 . The liquid composition according to claim 7 , further comprising a surfactant.

10 . The method according to claim 1 , wherein the solid reduced coenzyme Q10, prior to storing, is not pre-formulated with a clathrate forming material or a water-soluble excipient, is not coated with a coating material in a solid formulation, and is not present in a capsule of reduced coenzyme Q10.

Assignees

• Kaneka Corp

Inventors

• YOKOCHI Yuichi
• Kitamura Shiro
• Fukuyama Yuka

Classifications

• A61K47/02

  Inorganic compounds · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61K47/14

  Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters · CPC title

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title