Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant

Patent metadata

Field	Value
Publication number	US-2025072898-A1
Application number	US-202418951638-A
Country	US
Kind code	A1
Filing date	Nov 18, 2024
Priority date	Jul 12, 2013
Publication date	Mar 6, 2025
Grant date	—

Abstract

Disclosed are methods and devices for obtaining patent hemostasis of the radial artery by compressing the uninstrumented ulnar artery to increase radial artery flow. The device comprises a band having an inflatable bladder for applying blunt pressure to the ulnar artery. The method comprises applying a pressure to the homolateral ulnar artery and applying a pressure to the radial artery at the access site to obtain hemostasis at the access site. The method further comprises administering an anticoagulant to a patient at a dose ranging from about 20 units per kg of body weight to about 30 units per kg of body weight.

First claim

1 . A method of obtaining patent hemostasis of a radial artery of a patient when performing a catheterization procedure at an access site of the radial artery, comprising performing the following steps:
(a) administering a dose of anticoagulant to the patient during the catheterization procedure, wherein the dose of anticoagulant is less than an equivalent of 50 units of unfractionated heparin per kg of body weight; (b) applying a compressive pressure to the radial artery at the access site for a duration of time, wherein the duration of time is less than 120 minutes; (c) attaining patent hemostasis of the radial artery; wherein step (a) comprises administering anticoagulant at any time after introduction of a catheter or an introducer sheath and before removal of the catheter or the introducer sheath; and wherein step (b) comprises the compressive pressure to the radial artery being applied using a first band comprising at least a first inflatable bladder, the first inflatable bladder applying a compressive pressure to the radial artery at the access site.

2 . The method of claim 1 , further comprising a step of monitoring and/or confirming patency of the radial artery, the step of monitoring and/or confirming patency of the radial artery being performed by sensing skin blood flow and/or pulsation at a fingertip or other location downstream of the access site.

3 . The method of claim 2 , wherein the step of confirming patency includes the use of digital plethysmography.

4 . The method of claim 1 , where the anticoagulant is selected from a group consisting of: heparin, dalteparin, danaparoid, enoxaparin, unfractionated heparin, low molecular weight heparin, direct thrombin inhibitors including hirudin, argatroban, bivalirudin, and combinations or derivatives thereof.

5 . The method of claim 1 , wherein the dose of anticoagulant in step (a) is about an equivalent of 25 units of unfractionated heparin per kg of body weight.

6 . The method of claim 1 , wherein the dose of anticoagulant in step (a) is less than an equivalent of 25 units of unfractionated heparin per kg of body weight.

7 . The method of claim 1 , wherein the dose of anticoagulant in step (a) is in the range of an equivalent of 20-40 units of unfractionated heparin per kg of body weight.

8 . The method of claim 1 , wherein the dose of anticoagulant in step (a) is in the range of an equivalent of 15-30 units of unfractionated heparin per kg of body weight.

9 . The method of claim 1 , wherein the duration of time is about 60 minutes.

10 . The method of claim 1 , wherein the duration of time is less than 60 minutes.

11 . The method of claim 1 , wherein the compressive pressure to the radial artery in step (b) is gradually reduced after about 60 minutes of compression of the radial artery at the access site.

12 . The method of claim 1 , wherein the compressive pressure to the radial artery in step (b) is gradually reduced and weaned off from the radial artery access site, and the site is lightly dressed.

13 . The method of claim 12 , wherein the duration of weaning off the compressive pressure to the radial artery is in the range of 5-10 minutes.

14 . The method of claim 1 , further comprising applying a compressive pressure to an ipsilateral ulnar artery at an ulnar pressure site.

15 . The method of claim 14 , further comprising applying the compressive pressure to the ipsilateral ulnar artery using at least a second inflatable bladder, the first band comprising the second inflatable bladder.

16 . The method of claim 14 , wherein the compressive pressure to the ipsilateral ulnar artery is applied using a technique selected from a group consisting of (i) a second band comprising at least a second inflatable bladder, wherein the second bladder applies the ulnar pressure, (ii) a mechanical device applies a compressing force at the ulnar pressure site; (iii) manual pressure is applied at the ulnar pressure site.

17 . The method of claim 14 , wherein applying the compressive pressure to the ipsilateral ulnar artery compresses the ulnar artery partially or fully.

18 . The method of claim 14 , wherein the compressive pressure to the ipsilateral ulnar artery is applied intermittently.

19 . The method of claim 14 , wherein the compressive pressure to the ipsilateral ulnar artery is applied continuously.

20 . A method of obtaining patent hemostasis of a radial artery of a patient when performing a catheterization procedure at an access site of the radial artery, comprising performing the following steps:
(a) administering a dose of anticoagulant to the patient during the catheterization procedure, wherein the dose of anticoagulant is less than an equivalent of 50 units of unfractionated heparin per kg of body weight; (b) applying a compressive pressure to the radial artery at the access site for a duration of time, wherein the duration of time is less than 120 minutes; (c) monitoring and/or confirming patency of the radial artery, the step of monitoring and/or confirming patency of the radial artery being performed by sensing skin blood flow and/or pulsation at a fingertip or other location downstream of the access site; (d) attaining patent hemostasis of the radial artery; wherein step (a) comprises administering anticoagulant at any time after introduction of a catheter or an introducer sheath and before removal of the catheter or the introducer sheath; wherein step (b) comprises the compressive pressure to the radial artery being applied using a first band comprising at least a first inflatable bladder, the first inflatable bladder applying a compressive pressure to the radial artery at the access site; and wherein the compressive pressure to the radial artery in step (b) is gradually reduced and weaned off from the radial artery access site.

Assignees

• Pancholy Samir Bipin
• Vasoinnovations Inc

Inventors

• Pancholy Samir Bipin

Classifications

• A61B17/135

  inflatable · CPC title

• A61B17/1325 Primary

  with means for applying local pressure (pressure pads A61F5/30) · CPC title

• A61B17/12009

  Implements for ligaturing other than by clamps or clips, e.g. using a loop with a slip knot · CPC title

• A61B2017/12004

  for haemostasis, for prevention of bleeding · CPC title

• A61B17/12 Primary

  for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord · CPC title