Optical Pressure Sensor for Eye with Embedded Interrogation System

Patent metadata

Field	Value
Publication number	US-2025064317-A1
Application number	US-202318455981-A
Country	US
Kind code	A1
Filing date	Aug 25, 2023
Priority date	Aug 25, 2023
Publication date	Feb 27, 2025
Grant date	—

Abstract

An intraocular implant comprising: a pressure sensor implantable in an eye, wherein the pressure sensor comprises a substrate having a first side coupled to a membrane to define an optical cavity with a depth that varies based on an intraocular pressure of the eye; and an enclosure coupled to a second side of the substrate to define a hermetic cavity comprising a light source and a detector operable to interrogate the pressure sensor and obtain data corresponding to an intraocular pressure of the eye based on the interrogation.

First claim

What is claimed is:

1 . An intraocular implant comprising:
a pressure sensor implantable in an eye, wherein the pressure sensor comprises a substrate having a first side coupled to a membrane to define an optical cavity with a depth that varies based on an intraocular pressure of the eye; and an enclosure coupled to a second side of the substrate to define a hermetic cavity comprising a light source and a detector operable to interrogate the pressure sensor and obtain data corresponding to an intraocular pressure of the eye based on the interrogation.

2 . The intraocular implant of claim 1 wherein the light source is a first light source, and the implant further comprises a second light source and a non-polarizing beam splitter positioned in the hermetic cavity to interrogate the pressure sensor.

3 . The intraocular implant of claim 2 wherein the first light source emits a beam of light having a first wavelength and the second light sources emits a beam of light having a second wavelength through the non-polarizing beam splitter to the detector to interrogate the pressure sensor.

4 . The intraocular implant of claim 1 wherein the implant further comprises an application-specific integrated circuit and a battery positioned in the hermetic cavity.

5 . The intraocular implant of claim 1 wherein the implant further comprises a light emitting diode in the hermetic cavity to optically transmit intraocular pressure data obtained by the interrogation of the pressure sensor to an external handheld reader device.

6 . The intraocular implant of claim 1 wherein the light source is arranged orthogonal to the detector.

7 . The intraocular implant of claim 1 wherein the light source is a single light source having an emission spectrum that changes over time.

8 . The intraocular implant of claim 1 further comprising a collimating lens and a beam splitter, and the light source emits a beam of light through the collimating lens to produce a number of light rays that pass through the beam splitter to interrogate different regions of the membrane.

9 . The intraocular implant of claim 8 wherein the detector is a first detector, and the implant further comprises a second detector, the first detect and the second detector are operable to receive a first light ray a second light ray reflected through the beam splitter, respectively.

10 . The intraocular implant of claim 1 wherein the pressure sensor is implanted in an anterior chamber of the eye.

11 . An intraocular pressure measurement system, comprising:
an intraocular implant implantable in an eye comprising a pressure sensor having a substrate having a first side coupled to a membrane to define an optical cavity with a depth that varies based on an intraocular pressure of the eye and an enclosure coupled to a second side of the substrate to define a hermetic cavity comprising a light source and a detector operable to interrogate the pressure sensor, and a transmitter operable to output data corresponding to an intraocular pressure of the eye based on the interrogation; and an external reader device comprising a processor configured to receive the output data and, based on the output, estimate the intraocular pressure of the eye.

12 . The system of claim 11 wherein the light source is a first light source, and the implant further comprises a second light source and a non-polarizing beam splitter positioned in the hermetic cavity to interrogate the pressure sensor.

13 . The system of claim 12 wherein the first light source emits a beam of light having a first wavelength and the second light source emits a beam of light having a second wavelength through the non-polarizing beam splitter to the detector to interrogate the pressure sensor.

14 . The system of claim 11 wherein the implant further comprises an application-specific integrated circuit and a battery positioned in the hermetic cavity.

15 . The system of claim 11 wherein the implant further comprises a light emitting diode in the hermetic cavity to optically transmit intraocular pressure data obtained by the interrogation of the pressure sensor to an external handheld reader.

16 . The system of claim 11 wherein the light source is arranged orthogonal to the detector.

17 . The system of claim 11 wherein the light source is a single light source having an emission spectrum that changes over time.

18 . The system of claim 11 further comprising a collimating lens and a beam splitter, and the light source emits a beam of light through the collimating lens to produce a number of light rays that pass through the beam splitter to interrogate different regions of the membrane.

19 . The system of claim 18 wherein the detector is a first detector, and the implant further comprises a second detector, the first detect and the second detector are operable to receive a first light ray a second light ray reflected through the beam splitter, respectively.

20 . The system of claim 11 wherein the intraocular implant is implanted in an anterior chamber of the eye.

Assignees

• Twenty Twenty Therapeutics Llc

Inventors

• Sinha Supriyo
• Costello Benedict
• Azar Dimitri

Classifications

• A61B2562/0247

  Pressure sensors · CPC title

• A61B2562/0238

  Optical sensor arrangements for performing transmission measurements on body tissue · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title

• A61B5/0017

  transmitting optical signals · CPC title

• A61B5/0004

  characterised by the type of physiological signal transmitted · CPC title