Solution electrospun fibers, compositions comprising the same and a process of manufacturing thereof

Patent metadata

Field	Value
Publication number	US-2025051519-A1
Application number	US-202218722254-A
Country	US
Kind code	A1
Filing date	Dec 13, 2022
Priority date	Dec 21, 2021
Publication date	Feb 13, 2025
Grant date	—

Abstract

The present invention relates to solution electrospun fibers comprising a ingredient in an amorphous form, compositions and their manufacturing process thereof. More specifically, the present invention relates to solution electrospun fibers and a compositions comprising at least one of said fibers, said fiber obtained by solution electrospinning a ingredient with a polymer.

First claim

1 . A process of manufacturing a solution electrospun fiber, comprising the steps of:
a) providing a solution comprising an ingredient, a polymer and a solvent; b) electrospinning the solution provided at step a) thereby obtaining a solution electrospun fiber comprising an amorphous form of the ingredient;
wherein step a) comprises providing the polymer at a concentration in said solution which is lower than the concentration at which the polymer is solution electrospinnable into fibers in the absence of the ingredient.

2 . The process according to claim 1 , wherein at step a) the ingredient is provided in an amount of at least 50%, preferably above 50% w/w of ingredient to polymer.

3 . The process according to any one of the previous claims , wherein at step a) the polymer is a poly(2-alkyl-2-oxazoline) (PAOx), preferably poly(2-ethyl-2-oxazoline) (PEtOx).

4 . The process according to claim 3 , wherein the polymer is poly(2-ethyl-2-oxazoline) (PEtOx).

5 . The process according to any one of the previous claims , wherein at step a) the ingredient and the polymer are selected from those providing a mixture consisting of said ingredient and polymer yielding a solution electrospun fiber having a glass transition temperature T g of at least about 25° C.

6 . The process according to any one of the previous claims , wherein at step a) the ingredient is provided in an amount of at least 55% w/w, at least 60% w/w, at least 65% w/w, at least 70% w/w of ingredient to polymer.

7 . The process according to any one of the previous claims , wherein at step a) the polymer is a water-soluble polymer.

8 . The process according to any one of the previous claims , wherein at step a) the solvent comprises an acid.

9 . A solution electrospun fiber obtainable by means of the method defined in claims 1 to 8 , comprising:
an ingredient in an amorphous form; a polymer;
wherein the ingredient is in an amount of at least 50%, preferably above 50% w/w of ingredient to polymer, preferably in an amount of at least 55% w/w, at least 60% w/w, at least 65% w/w, at least 70% w/w.

10 . A solution electrospun fiber comprising:
an ingredient in an amorphous form; a polymer;
wherein the solution electrospun fiber is electrospun from a polymer solution comprising a polymer at a concentration in said solution which is lower than the concentration at which the polymer is solution electrospinnable in the absence of the ingredient.

11 . The fiber according to claim 10 , wherein the ingredient is in an amount of at least 50%, above 50% w/w of ingredient to polymer, preferably in an amount of at least 55% w/w, at least 60% w/w, at least 65% w/w, at least 70% w/w.

12 . The fiber according to any one of claims 9 to 11 , wherein the polymer is a poly(2-alkyl-2-oxazoline) (PAOx), preferably poly(2-ethyl-2-oxazoline) (PEtOx).

13 . The fiber according to any one of claims 9 to 12 , wherein the polymer is an amorphous polymer.

14 . The fiber according to any one of claims 9 to 13 , wherein the ingredient and the polymer are selected from those providing a mixture consisting of said ingredient and polymer yielding a solution electrospun fiber having a glass transition temperature T g of at least about 25° C.

15 . A composition comprising a solution electrospun fiber as defined in any one of claims 9 to 14 .

Assignees

• Univ Gent

Inventors

• Hoogenboom Richard
• Vervaet Chris
• Becelaere Jana
• De Clerck Karen

Classifications

• D01D5/003

  the material being a polymer solution or dispersion (D01D5/0053 takes precedence) · CPC title

• A61K31/635

  having a heterocyclic ring, e.g. sulfadiazine · CPC title

• A61K31/4184

  condensed with carbocyclic rings, e.g. benzimidazoles · CPC title

• A61K31/216

  of acids having aromatic rings, e.g. benactizyne, clofibrate · CPC title

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title