Carbon-iodine conjugated polymer and preparation thereof, and use thereof for preparing localization marker

Patent metadata

Field	Value
Publication number	US-2025051510-A1
Application number	US-202418926730-A
Country	US
Kind code	A1
Filing date	Oct 25, 2024
Priority date	Nov 30, 2021
Publication date	Feb 13, 2025
Grant date	—

Abstract

Described are a carbon-iodine conjugated polymer and preparation thereof, an imaging marker thereof, and uses thereof for preparing a localization marker, and belongs to the technical field of imaging markers. The conjugated structure enables the polymer to have strong absorption in a visible light region, and high iodine content of up to 84.1 % corresponds to the strong imaging ability thereof. During surgery, on the basis of the dual guidance of a polymer-based image marker and naked eye observation, the marker can better facilitate determination of tumor resection margins, achieving precise resection of tumors and minimizing damage to surrounding normal tissues. During cyberknife-based treatment, the polymer can replace clinical gold markers to provide ray marker guidance. Absence of metal artifacts improves ray imaging quality and the accuracy of radiation dose distribution, good biocompatibility enhances the stability of the relative position of the marker, and radiotherapy side effects can be further reduced.

First claim

1 . A method of localized marking in an imaging of a subject, comprising:
administering, into an area of the subject, an effective amount of a carbon-iodine conjugated polymer as a localization marker; wherein the carbon-iodine conjugated polymer has the following Formula I:

2 . The method of claim 1 , wherein the imaging is X-ray imaging, and the localization marker is an X-ray marker.

3 . The method of claim 2 , wherein the imaging is computed tomography (CT) imaging, and the localization marker is a CT imaging marker.

4 . The method of claim 2 , wherein the method further comprises emitting an X-ray through the subject; and measuring an attenuation of the X-ray so as to identify a location of the localization marker.

5 . The method of claim 1 , wherein the carbon-iodine conjugated polymer is administered in a form of an aqueous dispersion.

6 . The method of claim 1 , wherein the carbon-iodine conjugated polymer is administered in combination with iohexol.

7 . The method of claim 1 , wherein the imaging is CT imaging, and an effective amount of the carbon-iodine conjugated polymer is an amount such that a CT signal intensity of the marker is two times or more than a CT signal intensity of a background tissue of the subject.

8 . The method of claim 1 , wherein the effective amount is 5 mg/ml.

9 . The method of claim 1 , wherein the localized marking is conducted in vivo.

10 . The method of claim 1 , wherein the subject has a tumor, and the area of the subject comprises the tumor.

11 . The method of claim 10 , wherein the carbon-iodine conjugated polymer is administered around the tumor so as to mark the tumor.

12 . The method of claim 1 , wherein the carbon-iodine conjugated polymer is administered in a form of an aqueous dispersion, and the aqueous dispersion comprises an amphiphilic polymer.

13 . The method of claim 12 , wherein the amphiphilic polymer is C18-PMH-PEG.

14 . The method of claim 1 , wherein an iodine content of the carbon-iodine conjugated polymer is up to 84.1%.

15 . A method of computed tomography (CT) localized marking in a cyberknife treatment of a tumor in a subject, comprising:
administering, into an area of the subject, an effective amount of a carbon-iodine conjugated polymer as a CT localization marker;
wherein the carbon-iodine conjugated polymer has the following Formula I:

16 . The method of claim 15 , further comprising emitting an X-ray through the subject; and
measuring an attenuation of the X-ray in real-time so as to track the CT localization marker during the cyberknife treatment.

17 . The method of claim 15 , wherein the area comprises the tumor.

18 . The method of claim 15 , wherein the carbon-iodine conjugated polymer is administered in a form of an aqueous dispersion, and the aqueous dispersion comprises an amphiphilic polymer.

19 . The method of claim 18 , wherein the amphiphilic polymer is C18-PMH-PEG.

20 . The method of claim 15 , wherein an iodine content of the carbon-iodine conjugated polymer is up to 84.1%.

Assignees

• Univ Huazhong Science Tech

Inventors

• Luo Liang
• Yin Mingming
• Liu Xiaoming
• Meng Fanling

Classifications

• C08G2261/3328

  alkyne-based · CPC title

• C08G2261/3327

  alkene-based · CPC title

• C08G2261/18

  conjugated · CPC title

• C08G2261/146

  Side-chains containing halogens · CPC title

• C08G2261/1432

  containing amide groups · CPC title