Weight-based systems for use in extracorporeal blood treatment

Patent metadata

Field	Value
Publication number	US-2025050000-A1
Application number	US-202218719082-A
Country	US
Kind code	A1
Filing date	Dec 14, 2022
Priority date	Dec 15, 2021
Publication date	Feb 13, 2025
Grant date	—

Abstract

Ultrafiltration (UF) is monitored in a weight-based system for extracorporeal blood treatment. The system comprises a container holding a fluid that is pumped to or from a dialyzer by a pump. The container is intermittently refilled or drained by an adjustment arrangement during a level adjustment period (LAP). A scale measures the weight of the container. A monitoring device is operated to determine, before and after the LAP while the adjustment arrangement is deactivated and the pump is operated at a known setting, first and second values of a parameter of the pump based on a weight signal from the scale. The parameter may be flow rate or stroke volume. The monitoring device estimates a time profile for the parameter during the LAP based on the first and second values and determines the UF parameter based on the time profile.

First claim

1 : A device for monitoring ultrafiltration in a system for extracorporeal treatment of blood, the device comprising:
an input interface, which is configured to receive a measurement signal representative of a momentary weight of a container in the system, the container being connected on a first fluid path to a first dialyzer port for dialysis fluid on a dialyzer for extracorporeal treatment of blood, a pumping device being arranged in the first fluid path , the container being further connected on a second fluid path to an adjustment arrangement for level adjustment of a fluid in the container, and processor circuitry, which is connected to the input interface and configured to perform a monitoring procedure in relation to a level adjustment period, in which the adjustment arrangement is selectively activated to perform the level adjustment and the pumping device is operated at a known setting, wherein the processor circuitry, in the monitoring procedure, is configured to:
determine, during a first measurement period prior to the level adjustment period and based on the measurement signal, a first value of a pumping parameter of the pumping device while the adjustment arrangement is deactivated and the pumping device is operated at the known setting,
determine, during a second measurement period subsequent to the level adjustment period and based on the measurement signal, a second value of the pumping parameter while the adjustment arrangement is deactivated and the pumping device is operated at the known setting,
estimate, based on the first and second values, a time profile of the pumping parameter in the level adjustment period, and
determine an ultrafiltration parameter for the level adjustment period based on the time profile.

2 : The device of claim 1 , wherein the processor circuitry is configured to estimate the time profile by performing a linear interpolation of the first and second values.

3 : The device of claim 1 , wherein the pumping parameter is one of: a flow rate generated by the pumping device or a stroke volume of the pumping device.

4 : The device of claim 1 , wherein the pumping parameter is a stroke volume of the pumping device, and wherein the processor circuitry is further configured to receive, via the input interface, a further measurement signal representative of a speed of the pumping device, and determine the first and second values of the pumping parameter based on the measurement signal and the further measurement signal during the first and second measurement period, respectively.

5 : The device of claim 4 , wherein the processor circuitry is further configured to: determine a fluid flow parameter for the level adjustment period, based on the time profile and the further measurement signal during the level adjustment period, and determine the ultrafiltration parameter based on the fluid flow parameter.

6 : The device of claim 5 , wherein the fluid flow parameter represents a total amount of the fluid pumped by the pumping device during the level adjustment period.

7 : The device of claim 6 , wherein the processor circuitry is configured to:
determine, based on the further measurement signal, a count of pumping strokes performed by the pumping device during the level adjustment period, calculate an average stroke volume for the level adjustment period based on the time profile, and determine the fluid flow parameter as a function of the average stroke volume and the count of the pumping strokes.

8 : The device of claim 4 , wherein the further measurement signal comprises a predefined number of pulses for each pumping stroke of the pumping device.

9 : The device of claim 1 , wherein the ultrafiltration parameter comprises an amount of ultrafiltrate extracted from the blood in the dialyzer.

10 : The device of claim 1 , wherein the processor circuitry is configured to:
receive, via the input interface, an input signal which is representative of fluid pressure in the first fluid path between the container and the pumping device or which is representative of a control signal for the pumping device, and estimate the time profile based on the first and second values and the input signal during the level adjustment period.

11 : The device of claim 10 , wherein the processor circuitry is further configured to:
obtain calibration data representing a relation between the fluid pressure and the pumping parameter; and estimate the time profile by converting, by use of the calibration data, the input signal received during the level adjustment period into values of the pumping parameter.

12 : The device of claim 1 , wherein the processor circuitry is further configured to:
monitor the measurement signal for detection of a step-change during the level adjustment period, and to initiate, upon detection of the step-change, a dedicated action.

13 : The device of claim 12 , wherein the dedicated action comprises one or more of: a modification of the level adjustment period, accounting for the step-change when estimating the time profile of the pumping parameter, or a modification of a pumping speed of the pumping device.

14 : The device of claim 13 , wherein the modification of the level adjustment period results in a stop of the level adjustment.

15 : The device of claim 13 , wherein the processor circuitry is configured to, upon the detection of the step-change, determine a magnitude of the step-change, wherein the dedicated action uses the magnitude.

16 : The device of claim 15 , wherein the modification of the pumping speed is based on the magnitude to at least partly compensate for a change in flow rate in the first fluid path resulting from the step-change.

17 : The device of claim 15 , wherein the processor circuitry is configured to estimate the time profile of the pumping parameter based on the first and second values, the magnitude, and a timing of the step-change during the level adjustment period.

18 : The device of claim 12 , wherein the processor circuitry is configured to generate, based on the measurement signal, a monitoring signal that represents momentary change of the weight of the container, and detect the step-change in the monitoring signal.

19 : The device of claim 12 , wherein the pumping device, when operated at the known setting, is configured to repeatedly generate a temporal variation in fluid flow rate in the first fluid path, and wherein the processor circuitry is configured to detect the step-change as a momentary change in an amplitude of the temporal variation as embedded in the measurement signal.

20 : The device of claim 19 , wherein the processor circuitry is configured to generate, based on the measurement signal, a monitoring signal that represents a momentary change of the weight of the container, and detect the step-change based on the monitoring signal.

21 : The device of claim 20 , wherein the processor circuitry is configured to generate the monitoring signal to represent a derivative of the measurement signal.

22 : The device of claim 20 , wherein the processor circuitry is configured to generate a difference signal by subtracting a representation of the temporal variation from the monitoring signal and detect the step-change in the difference signal.

23 : The device of claim 22 , wherein the processor circuitry is configured to process the difference signal for detection of the temporal variation, wherein the step-change is detected by presence of the tempora

Assignees

• Baxter Int
• Baxter Healthcare Sa

Inventors

• Jansson Olof
• Pettersson Michael
• Hertz Thomas
• Fors Jonas
• Borgqvist Per-Olof

Classifications

• A61M1/1603

  Regulation parameters · CPC title

• A61M1/1656

  Apparatus for preparing dialysates · CPC title

• A61M1/1643 Primary

  with weighing of fresh and used dialysis fluid · CPC title

• A61M2205/3393

  by weighing the reservoir · CPC title

• A61M1/1613 Primary

  Profiling or modelling of patient or predicted treatment evolution or outcome · CPC title