Metal Salt Compositions

Patent metadata

Field	Value
Publication number	US-2025049681-A1
Application number	US-202418808749-A
Country	US
Kind code	A1
Filing date	Aug 19, 2024
Priority date	Dec 21, 2010
Publication date	Feb 13, 2025
Grant date	—

Abstract

Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.

First claim

1 . An oral care composition comprising:
a first metal salt, having a solubility of greater than 0.001 g/100 mL in water at 20° C.; a second metal salt, having a solubility of 0.001 g/100 mL, or less, in water at 20° C.; and a free water content of greater than about 10%, by weight; polyvinyl methyl ether/maleic anhydride (PVME/MA) copolymers; and wherein the first metal salt and the second metal salt are independently selected from a zinc salt, a stannous salt and a copper salt; and wherein the second metal salt is present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first or second metal salt.

2 . The composition of claim 1 , wherein the first metal salt and the second metal salt are salts of the same metal.

3 . The composition of claim 1 , wherein the second metal salt is present in an amount effective to provide a synergistic increase in delivery of the metal ion of the first metal salt.

4 . The composition of claim 1 , wherein the first metal salt is selected from: zinc citrate trihydrate, zinc chloride, zinc lactate, zinc nitrate, zinc acetate, zinc gluconate, zinc glycinate and zinc sulfate.

5 . The composition of claim 4 , wherein the second metal salt is selected from: zinc oxide, zinc phosphate, zinc pyrophosphate, zinc silicate, zinc oleate, zinc hydroxide, zinc peroxide, and zinc sulfide.

6 . The composition of claim 5 , comprising:
from about 0.1 to about 5%, by weight, of said first metal salt; and from about 0.05 to about 2%, by weight, of said second metal salt.

7 . The composition of claim 1 , comprising:
from about 0.5 to about 4%, by weight, of said first metal salt; and from about 0.1 to about 1.5%, by weight, of said second metal salt.

8 . The composition of claim 1 , comprising:
from about 1 to about 3%, by weight, of said first metal salt; and from about 0.2 to about 0.75%, by weight, of said second metal salt.

9 . The composition of claim 1 , comprising:
about 2%, by weight, of said first metal salt; and about 0.25%, by weight, of said second metal salt.

10 . The composition of claim 1 , comprising:
about 2%, by weight, of said first metal salt; and about 0.5%, by weight, of said second metal salt.

11 . The composition of claim 1 , further comprising one or more components selected from a fluoride ion source; a tartar control agent; a buffering agent; an antibacterial agent; an abrasive; and a combination of two or more thereof.

12 . The composition of claim 11 , wherein at least one of the one or more components is a fluoride ion source selected from: stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and a combination of two or more thereof.

13 . The composition of claim 11 , wherein at least one of the one or more components is a tartar control agent selected from: sodium tripolyphosphate, sodium tetrapolyphosphate, mono-, di-, tri- and tetrasodium pyrophosphates, sodium trimetaphosphate, sodium hexametaphosphate; potassium tripolyphosphate, potassium tetrapolyphosphate, mono-, di-, tri- and tetrapotassium pyrophosphates, potassium trimetaphosphate, potassium hexametaphosphate; and a combination of two or more thereof.

14 . The composition of claim 1 , wherein the composition comprises greater than about 15%, by weight, free water.

15 . A method of treating or preventing a disease or condition of the oral cavity comprising contacting an oral cavity surface of a patient in need thereof with the composition of claim 1 .

16 . (canceled)

17 . The composition of claim 1 , wherein the free water is present in an amount from about 10 to 20%, by weight, based on the total weight of the oral care composition.

18 . The composition of claim 1 further comprising: a sweetener present in an amount from about 0.001 to about 5%, by weight, based on the total weight of the oral care composition.

19 . The composition of claim 18 , wherein the sweetener consists of sodium saccharin.

20 . The composition of claim 1 , wherein the first metal salt is selected from a stannous salt.

21 . The composition of claim 1 further comprising: an antiplaque agent selected from a stannous salt.

Assignees

• Colgate Palmolive Co

Inventors

• Maloney Venda Porter
• Patel Vyoma
• Fisher Steven
• Morgan André
• Prencipe Michael
• Jaracz Stanislav

Classifications

• A61K8/24

  Phosphorous; Compounds thereof · CPC title

• A61K8/44

  Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof · CPC title

• A61K8/365

  Hydroxycarboxylic acids; Ketocarboxylic acids · CPC title

• A61K8/362

  Polycarboxylic acids · CPC title

• A61K8/361

  Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof · CPC title