Systems and methods for automated separation and recovery of astatine

Patent metadata

Field	Value
Publication number	US-2025042736-A1
Application number	US-202118719036-A
Country	US
Kind code	A1
Filing date	Dec 14, 2021
Priority date	Dec 14, 2021
Publication date	Feb 6, 2025
Grant date	—

Abstract

Systems and methods for automated separation and recovery of compounds from solution are disclosed herein. In some embodiments, the system can use a pump in fluid/air communication with a chromatography column to dissolve and recover astatine from a solution containing astatine, bismuth, and nitric acid. The system can be in communication with a controller that can automate and/or remotely signal each component of the system to execute the recovery without manual user inputs.

First claim

1 . A compound recovery system, comprising:
a first column configured to extract astatine from a dissolution solution having astatine dissolved therein, the column having an extraction medium with a solvent associated therewith; a pump in fluid communication with the column, the pump being configured to deliver the dissolution solution to the column; and a control system in communication with the pump, the control system being configured to regulate flow of the dissolution solution through the pump via a signal, wherein the signal is automated or placed from a remote location.

2 . The system of claim 1 , further comprising a dissolution vessel in fluid communication with the pump and the column, the dissolution vessel being configured to form the dissolution solution by mixing an irradiated target material and a medium therein.

3 . The system of claim 2 , further comprising one or more selectors in fluid communication with the pump, the one or more selectors being configured to deliver the solvent or the dissolution solution therethrough.

4 . The system of claim 3 , wherein an orientation of the one or more selectors is determined by the signal from the control system.

5 . The system of claim 3 , wherein the control system is configured to be in communication with the pump and the one or more selectors substantially simultaneously.

6 . The system of claim 3 , wherein the one or more selectors contains a single inlet and a plurality of outlets.

7 . The system of claim 3 , wherein the one or more selectors contains a single outlet and a plurality of inlets.

8 . The system of claim 4 , wherein the one or more selectors are in fluid communication with one or more vials containing a solution therein, the pump being configured to deliver the medium through the one or more selectors into the dissolution vessel.

9 . The system of claim 8 , wherein the medium includes one or more of nitric acid, hydrobromic acid, hydrochloric acid, sulfuric acid, or perchloric acid.

10 . The system of claim 1 , wherein the extraction medium is a resin bed.

11 . The system of claim 1 , wherein the solvent can include one or more of octanone, 3-octanone, or 1-octanol.

12 . The system of claim 1 , wherein extraction of astatine occurs without heating.

13 . The system of claim 1 , further comprising a quality assurance device in fluid communication with the pump being configured to sample a portion of the dissolution solution.

14 . The system of claim 1 , further comprising a second column configured to receive a portion of the dissolution solution therethrough.

15 . The system of claim 14 , wherein the second column is arranged in series with the first column.

16 . The system of claim 14 , wherein the second column is arranged in parallel with the first column.

17 . A method for compound recovery, the method comprising:
exposing a target material having one or more compounds therein to an acidic medium to dissolve the target material within the acidic medium to form a dissolution solution having the target material and the one or more compounds therein; passing the dissolution solution through a chromatography column to extract the one or more compounds therefrom, the one or more compounds being extracted into a resin bed disposed within the chromatography column; and washing the resin bed to remove non-extracted dissolution solution from the column, wherein each of exposing the target material, passing the dissolution solution through the chromatography column, and washing the resin bed occurs in response to an automated signal or a signal placed from a remote location.

18 . The method of claim 17 , wherein the resin bed is washed with the acidic medium.

19 . The method of claim 17 , wherein the acidic medium comprises one or more of nitric acid, hydrobromic acid, hydrochloric acid, sulfuric acid, or perchloric acid.

20 . (canceled)

21 . The method of claim 17 , wherein the dissolution solution is formed approximately over a range of about five minutes to about thirty minutes.

22 .- 30 . (canceled)

Assignees

• Texas A & M Univ Sys

Inventors

• Tereshatov Evgeny E
• Burns Jonathan D
• Mcintosh Lauren A
• Tabacaru Gabriel C
• Yennello Sherry J

Classifications

• B01D15/1894

  Liquid-liquid chromatography, e.g. centrifugal partition chromatography or extraction chromatography · CPC title

• B01D15/361

  Ion-exchange · CPC title

• B01D15/1864

  using two or more columns · CPC title

• B01D15/12 Primary

  relating to the preparation of the feed · CPC title

• G01N30/20

  using a sampling valve · CPC title