Systems for treating pulmonary infections

Patent metadata

Field	Value
Publication number	US-2025041321-A1
Application number	US-202418733525-A
Country	US
Kind code	A1
Filing date	Jun 4, 2024
Priority date	May 21, 2012
Publication date	Feb 6, 2025
Grant date	—

Abstract

Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection. The system includes a pharmaceutical formulation comprising a liposomal aminoglycoside dispersion, and the lipid component of the liposomes consist essentially of electrically neutral lipids. The system also includes a nebulizer which generates an aerosol of the pharmaceutical formulation at a rate greater than about 0.53 gram per minute. The aerosol is delivered to the subject via inhalation for the treatment of the pulmonary infection.

First claim

1 - 29 . (canceled)

30 . A method for treating or prophylaxis against a pulmonary infection in a patient, the method comprising:
aerosolizing a pharmaceutical formulation comprising a liposomal complexed aminoglycoside, wherein the pharmaceutical formulation is an aqueous dispersion and is aerosolized at a rate greater than about 0.53 gram per minute, and administering the aerosolized pharmaceutical formulation to the lungs of the patient; wherein the aerosolized pharmaceutical formulation comprises a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and the lipid component of the liposome consists of electrically neutral lipids, and the MMAD of the aerosol is less than about 4.2 μm, as measured by the ACI, or less than about 4.9 μm, as measured by the NGI.

31 - 70 . (canceled)

71 . A liposomal aminoglycoside aerosol comprising an aminoglycoside and a liposome comprising DPPC and cholesterol, wherein about 65% to about 75% of the aminoglycoside is liposomal complexed and the liposomal aminoglycoside aerosol is generated at a rate greater than about 0.53 gram per minute.

72 - 146 . (canceled)

Assignees

• Insmed Inc

Inventors

• Perkins Walter
• Malinin Vladimir
• Li Xingong
• Miller Brian
• Seidel Dominique
• Holzmann Philipp
• Schulz Harald
• Hahn Michael

Classifications

• B05B17/0646

  Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto · CPC title

• A61M11/02

  operated by air {or other gas} pressure applied to the liquid {or other product} to be sprayed or atomised {(sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C)} · CPC title

• A61M11/005

  using ultrasonics (spraying or atomising liquids using ultrasonic vibrations in general B05B17/06) · CPC title

• A61K9/1271

  Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers (liposomes as conjugates {A61K47/6911}) · CPC title

• A61K9/0078

  for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions · CPC title