Hydroxypropyl methylcellulose acetate succinate powder, and method of producing the same

Patent metadata

Field	Value
Publication number	US-2025034284-A1
Application number	US-202418784053-A
Country	US
Kind code	A1
Filing date	Jul 25, 2024
Priority date	Jul 26, 2023
Publication date	Jan 30, 2025
Grant date	—

Abstract

Provided is a method of producing hydroxypropyl methylcellulose acetate succinate powder capable of inhibiting aggregation of particles of the precipitated esterified cellulose ether and reducing produced amount of fine powder to thereby obtain the esterified cellulose ether in high yield. The method of producing hydroxypropyl methylcellulose acetate succinate powder comprises an esterification reaction step, a precipitation step, a washing/recovering step and a drying step, wherein the precipitation step is a step of introducing the reaction solution, obtained in the esterification reaction step, and water into a mixer provided with a rotatable rotor having blades and a perforated plate arranged to surround the rotor in a direction perpendicular to a radial direction of the rotor to allow a suspension, containing precipitated hydroxypropyl methylcellulose acetate succinate particles, to pass through the perforated plate to be discharged therethrough.

First claim

What is claimed is:

1 . A method of producing hydroxypropyl methylcellulose acetate succinate powder comprising the steps of:
esterifying hydroxypropyl methylcellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid to prepare a reaction solution containing hydroxypropyl methylcellulose acetate succinate; introducing the reaction solution and water into a mixer provided with a rotatable rotor having blades and a perforated plate arranged to surround the rotor in a direction perpendicular to a radial direction of the rotor for precipitation, and allowing a suspension, containing precipitated hydroxypropyl methylcellulose acetate succinate particles, to pass through the perforated plate to be discharged therethrough; washing the hydroxypropyl methylcellulose acetate succinate particles in the suspension and recovering the washed hydroxypropyl methylcellulose acetate succinate particles; and drying the washed hydroxypropyl methylcellulose acetate succinate particles.

2 . The method according to claim 1 , wherein the perforated plate has openings each having an opening area of 0.1 to 10.0 mm 2 .

3 . The method according to claim 1 , wherein a peripheral speed of the outermost circumference of the blades is 5.0 to 20.0 m/s.

4 . The method according to claim 1 , wherein 200 to 600 parts by mass of water per 100 parts by mass of the reaction solution is added into the reaction solution.

5 . The method according to claim 1 , wherein an average particle diameter of the hydroxypropyl methylcellulose acetate succinate particles is 500 to 2000 μm when the diameter is estimated from particle size distribution of the hydroxypropyl methylcellulose acetate succinate particles in the suspension in accordance with a wet sieving test as set forth in JIS Z8815, and wherein a mass percentage of the particles having a diameter of 250 μm or less in the total mass of the particles is 15.0% or less.

6 . A hydroxypropyl methylcellulose acetate succinate powder, wherein an average particle diameter of the hydroxypropyl methylcellulose acetate succinate powder as determined in accordance with a dry sieving test as set forth in JIS Z8815 is 300 μm or more and 1000 μm or less, the powder has a loose bulk density of 0.30 g/mL or less, and a degree of compression of the powder, defined as a ratio of the difference between a tapped bulk density and a loose bulk density relative to the tapped bulk density, is 10% or less.

Assignees

• Shinetsu Chemical Co

Inventors

• Kitaguchi Taishi
• Kurotani Shinichi
• Hoshino Tsuyoshi
• Kitamura Akira

Classifications

• C08B11/20 Primary

  Post-etherification treatments of chemical or physical type, {e.g. mixed etherification in two steps}, including purification · CPC title

• C08B15/08

  Fractionation of cellulose, e.g. separation of cellulose crystallites · CPC title

• C08B11/22

  Isolation · CPC title

• C08B13/00 Primary

  Preparation of cellulose ether-esters · CPC title

• C08B3/16 Primary

  Preparation of mixed organic cellulose esters {, e.g. cellulose aceto-formate or cellulose aceto-propionate} · CPC title