PROCESS FOR REMOVING Pb2+ IONS FROM BODILY FLUIDS USING METAL TITANATE ION EXCHANGERS

Patent metadata

Field	Value
Publication number	US-2025032537-A1
Application number	US-202418782880-A
Country	US
Kind code	A1
Filing date	Jul 24, 2024
Priority date	Jul 25, 2023
Publication date	Jan 30, 2025
Grant date	—

Abstract

A process for removing Pb 2+ ions from fluids, such as gastrointestinal fluids is described. The process involves contacting gastrointestinal fluid with a particulate metal titanate ion exchanger represented by the empirical formula:
A m Ti x M y O z
where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, lithium ion, calcium ion, magnesium ion, hydronium ion, and mixtures thereof, and M is optionally at least one framework metal selected from niobium (5+), zirconium (4+), tin (4+), iron (3+), iron (2+), cobalt (2+), and manganese (2+). The particulate metal titanate ion exchangers of the present disclosure are synthesized in the presence of complexing agents, including at least one multihydroxyl-containing complexing agent (MHCA), which facilitate metal transport and incorporation while imparting beneficial properties such as large aggregate size, well-behaved particle size distribution, and macroporosity.

First claim

What is claimed is:

1 . A particulate metal titanate ion exchanger having an empirical formula on an anhydrous basis of:
A m Ti x M y O z wherein A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, lithium ion, calcium ion, magnesium ion, hydronium ion or mixtures thereof; M is optionally at least one framework metal selected from niobium (5+), zirconium (4+), tin (4+), iron (3+), iron (2+), cobalt (2+), and manganese (2+); “m” is the mole ratio of A to total metal (total metal=Ti+M) and has a value from 0.10 to 0.60; “x” is the mole fraction of total metal that is Ti and has a value from 0.5 to 1; “y” is the mole fraction of total metal that is M and has a value from zero to 0.5, wherein x+y=1; and “z” is the mole ratio of O to total metal and has a value from 1.55 to 2.85, wherein the particulate metal titanate ion exchanger having been synthesized in the presence of at least one multihydroxyl-containing complexing agent (MHCA), and wherein the particulate metal titanate ion exchanger exhibits a median particle size of greater than 3 microns (μm).

2 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger is an acid-treated particulate metal titanate ion exchanger.

3 . The ion exchanger of claim 1 , wherein A is potassium ion, hydronium ion, or a mixture thereof.

4 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger is a polycrystalline aggregate metal titanate ion exchanger.

5 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger is macroporous.

6 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger has spherical morphology.

7 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger has amorphous morphology.

8 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger is a powder.

9 . The ion exchanger of claim 1 , wherein the median particle size is between 25 to 125 microns (μm).

10 . The ion exchanger of claim 1 , wherein less than 3% of the particles of the particulate metal titanate ion exchanger have a particle size of less than 3 microns (μm).

11 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger has
a particle size distribution d 10 value of between about 5 microns (μm) and about 70 μm; a particle size distribution d 50 value of between about 25 μm and about 125 μm; and a particle size distribution d 90 value of between about 55 μm and about 185 μm.

12 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger is stable in a liquid environment at a pH of 1-2; substantially insoluble at a pH range of 1-13; or both.

13 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger has a Brunauer-Emmett-Teller (BET) surface area that is greater than 150 square meters per gram (m 2 /g), greater than 200 m 2 /g, or greater than 230 m 2 /g.

14 . The ion exchanger of claim 1 , wherein the particulate metal titanate ion exchanger has a distribution coefficient (K d ) for Pb 2+ of between about 50,000 to about 5,500,000 milliliters per gram (mL/g) in solution.

15 . The ion exchanger of claim 1 , wherein the at least one MHCA is selected from the group consisting of a sugar alcohol, a sugar, an aromatic compound, and any combination thereof, optionally wherein the at least one MHCA is d-sorbitol.

16 . The ion exchanger of claim 1 , wherein x is 1 and y is 0, and m is between 0.10 to 0.50.

17 . A macroporous particulate titanate ion exchanger having an empirical formula on an anhydrous basis of:
A m TiO z wherein A is an exchangeable cation selected from the group consisting of potassium ion, hydronium ion, and a mixture thereof, “m” is the mole ratio of A to Ti and has a value from 0.10 to 0.60; and “z” is the mole ratio of O to Ti and has a value from 2.05 to 2.60, wherein the macroporous titanate ion exchanger having been synthesized in the presence of a multihydroxyl-containing complexing agent (MHCA) that is d-sorbitol, wherein the macroporous particulate titanate ion exchanger exhibits a median particle size that is between 25 to 125 microns (μm), wherein less than 3.0% of the particles of the macroporous particulate titanate ion exchanger have a particle size less than 3 microns (μm), and wherein the macroporous particulate titanate ion exchanger has a Brunauer-Emmett-Teller (BET) surface area of at least 150 square meters per gram (m 2 /g).

18 . The ion exchanger of claim 17 , wherein the particulate metal titanate ion exchanger is an acid-treated particulate metal titanate ion exchanger.

19 . The ion exchanger of claim 17 , wherein the macroporous particulate titanate ion exchanger has amorphous morphology.

20 . The ion exchanger of claim 17 , wherein the macroporous particulate titanate ion exchanger has any one or more of:
a particle size distribution d 10 value of between about 5 microns (μm) and about 45 μm; a particle size distribution d 50 value of between about 25 μm and about 75 μm; and a particle size distribution d 90 value of between about 55 μm and about 140 μm.

21 . The ion exchanger of claim 17 , wherein the macroporous particulate titanate ion exchanger exhibits a median particle size that is between 25 to 125 microns (μm), wherein less than 0.5% of the particles of the macroporous particulate titanate ion exchanger have a particle size less than 3 microns (μm).

22 . The ion exchanger of claim 21 , wherein the particulate metal titanate ion exchanger is an acid-treated particulate metal titanate ion exchanger.

23 . The ion exchanger of claim 21 , wherein the macroporous particulate titanate ion exchanger has spherical morphology.

24 . The ion exchanger of claim 21 , wherein the macroporous particulate titanate ion exchanger has
a particle size distribution d 10 value of between about 30 microns (μm) and about 70 μm; a particle size distribution d 50 value of between about 55 μm and about 125 μm; and a particle size distribution d 90 value of between about 120 μm and about 180 μm.

25 . A method for selectively removing Pb 2+ toxins from gastrointestinal fluid, the process comprising contacting the fluid containing the toxins with a particulate metal titanate ion exchanger, resulting in an ion exchanged ion exchanger and thereby removing the Pb 2+ toxins from the fluid, the particulate metal titanate ion exchanger having an empirical formula on an anhydrous basis of:
A m Ti x M y O z
wherein
A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, lithium ion, calcium ion, magnesium ion, hydronium ion or mixtures thereof; M is optionally at least one framework metal selected from niobium (5+), zirconium (4+), tin (4+), iron (3+), iron (2+), cobalt (2+), and manganese (2+); “m” is the mole ratio of A to total metal (total metal=Ti+M) and has a value from 0.10 to 0.60; “x” is the mole fraction of total metal that is Ti and has a value from 0.5 to 1; “y” is the mole fraction of total metal that is M and has a value from zero to 0.5, wherein x+y=1; and “z” is the mole ratio of O to total metal and has a value from 1.55 to 2.85,
wherein the metal titanate ion exchanger having been synthesized in the presence of at least one multihydroxyl-containing complexing agent

Assignees

• Uop Llc

Inventors

• Lewis Gregory J
• Jakubczak Paulina
• Sylejmani-Rekaliu Mimoza
• Sheets William
• Kolev Evgeny
• Lobo Rodrigo
• Lehuta Keith
• Chudasama Subhadra

Classifications

• B01J20/28004

  Sorbent size or size distribution, e.g. particle size · CPC title

• A61K33/00

  Medicinal preparations containing inorganic active ingredients · CPC title

• B01J39/02

  Processes using inorganic exchangers · CPC title

• A61K33/06

  Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} · CPC title

• A61P39/04

  Chelating agents · CPC title