Occlusion resolution in medication delivery devices, systems, and methods

Patent metadata

Field	Value
Publication number	US-2025022569-A1
Application number	US-202418903820-A
Country	US
Kind code	A1
Filing date	Oct 1, 2024
Priority date	Jan 14, 2016
Publication date	Jan 16, 2025
Grant date	—

Abstract

Methods, devices, and systems of delivering infusion fluid (e.g., medication such as insulin) can detect, at multiple times during a dispensation period of time, a pressure level of the infusion fluid in an infusion fluid pathway, either directly or indirectly. Based on the detected pressure levels, one or more actual dispensation times that are after an intended dispensation time can be determined. In some cases, methods, devices, and systems provided herein can use variable occlusion alarm thresholds, which can depend on variables such as an age of an infusion set and/or a current analyte level. In some cases, methods, devices, and systems provided herein can automate medication delivery and use the actual dispensation times in a control algorithm determining medication deliveries.

First claim

1 . A method for detecting an occlusion in an automated medication delivery system comprising:
detecting at least one real-time analyte level for a user; determining a dosage of medication for delivery to the user based on the at least one real-time analyte level and a control algorithm adapted to minimized variations of glucose levels from a desired target or range, wherein the dosage of medication is determined without user input, wherein the control algorithm includes an estimation of active medication-on-board that excludes an estimation of medication-in-transit; initiating a dispensation of the determined dosage of the medication using a medication delivery device; measuring a pressure of the medication in an infusion fluid pathway of the medication delivery device; and initiating an occlusion alarm if the measured pressure exceeds a variable threshold, the variable threshold being dependent upon at least one detected blood glucose value.

2 . The method of claim 1 , comprising:
determining an estimate of active medication-on-board based on the amount of the medication delivered from the actual dispensation time; determining a suggested medication dosage based on the calculated active medication-on-board.

3 . The method of claim 1 , comprising:
determining an amount of medication that is stuck in transit in the infusion fluid pathway of the pump based on the pressure measurements wherein the actual dispensation time is determined based on a time that detected pressure decreases to a predetermined level, wherein an amount of medication stuck in transit is excluded from an active medication-on-board calculation performed by control circuitry of the medication delivery system.

4 . The method of claim 1 , wherein the medication-in-transit estimated based on the detected pressure level.

5 . The method of claim 4 , comprising: including at least part of an estimated medication-in-transit as part of the estimated active medication-on-board if the detected pressure level decreases.

6 . The method of claim 5 , comprising:
detecting pressure level decreased at last partially based on pressure detected in an infusion fluid pathway or a medication reservoir.

7 . The method of claim 1 , wherein detecting at least one real-time analyte level for the user comprises detecting one or more of: at least one real-time analyte value or at least one real-time analyte trend.

8 . The method of claim 1 , comprising:
changing the variable threshold for initiating the occlusion alarm in response to historical analyte data or recent meal events to minimize false positives.

9 . A portable infusion pump system, comprising:
a pump configured to dispense an infusion fluid; and a controller configured to: detect at least one real-time analyte level for a user; determine a dosage of medication for delivery to the user based on the at least one real-time analyte level and a control algorithm adapted to minimized variations of glucose levels from a desired target or range, wherein the dosage of medication is determined without user input, wherein the control algorithm includes an estimation of active medication-on-board that excludes an estimation of medication-in-transit; initiate a dispensation of the determined dosage of the medication using a medication delivery device; measure a pressure of the medication in an infusion fluid pathway of the medication delivery device; and initiate an occlusion alarm if the measured pressure exceeds a variable threshold, the variable threshold being dependent upon at least one detected blood glucose value.

10 . The portable infusion pump system of claim 9 , wherein the controller is configured to:
determine an estimate of active medication-on-board based on the amount of the medication delivered from the actual dispensation time; determine a suggested medication dosage based on the calculated active medication-on-board.

11 . The portable infusion pump system of claim 9 , wherein the controller is configured to:
determine an amount of medication that is stuck in transit in the infusion fluid pathway of the pump based on the pressure measurements wherein the actual dispensation time is determined based on a time that detected pressure decreases to a predetermined level, wherein an amount of medication stuck in transit is excluded from an active medication-on-board calculation performed by control circuitry of the medication delivery system.

12 . The portable infusion pump system of claim 9 , wherein the medication-in-transit estimated based on the detected pressure level.

13 . The portable infusion pump system of claim 12 , wherein the controller is configured to include at least part of an estimated medication-in-transit as part of the estimated active medication-on-board if the detected pressure level decreases.

14 . The portable infusion pump system of claim 13 , wherein the controller is configured to detect a pressure level decreased at last partially based on pressure detected in an infusion fluid pathway or a medication reservoir.

15 . The portable infusion pump system of claim 9 , wherein the controller is configured to detect at least one real-time analyte level for the based on one or more of: at least one real-time analyte value or at least one real-time analyte trend.

16 . The portable infusion pump system of claim 9 , wherein the controller is configured to change the variable threshold for initiating the occlusion alarm in response to historical analyte data or recent meal events to minimize false positives.

Assignees

• Insulet Corp

Inventors

• Mazlish Bryan
• Desborough Lane
• Raghunathan Ravi Shankar Rontala

Classifications

• A61M2230/201

  Glucose concentration · CPC title

• A61M2205/587

  Lighting arrangements · CPC title

• A61M2205/583

  by visual feedback · CPC title

• A61M2205/582

  by tactile feedback · CPC title

• A61M2205/581

  by audible feedback · CPC title