Optogenetic neural probe device with plurality of inputs and outputs and method of manufacturing the same

Patent metadata

Field	Value
Publication number	US-2024407650-A1
Application number	US-202418672674-A
Country	US
Kind code	A1
Filing date	May 23, 2024
Priority date	Jun 7, 2023
Publication date	Dec 12, 2024
Grant date	—

Abstract

An optogenetic neural probe device for transmitting an optical signal to a nerve cell or receiving a fluorescent signal from the nerve cell, including: an optical device alignment substrate; an optical device group on the optical device alignment substrate and including one or more optical devices; and one or more optogenetic neural probes, wherein each optogenetic neural probe from among the one or more optogenetic neural probes may include an optical neural probe substrate, an optical waveguide on the optical neural probe substrate, and an optical signal input/output port, wherein the optogenetic neural probe is configured to transmit the optical signal emitted from the optical device group to the optical signal input/output port through the optical waveguide.

First claim

What is claimed is:

1 . An optogenetic neural probe device comprising:
an optical device alignment substrate; an optical device group on the optical device alignment substrate, the optical device group comprising one or more optical devices; and one or more optogenetic neural probes, wherein each optogenetic neural probe from among the one or more optogenetic neural probes comprises an optical neural probe substrate, an optical waveguide on the optical neural probe substrate, and an optical signal input/output port, wherein the optogenetic neural probe is configured to transmit an optical signal emitted from the optical device group to the optical signal input/output port through the optical waveguide.

2 . The optogenetic neural probe device of claim 1 , wherein the optical device group comprises a first optical device and a second optical device, and
wherein a central wavelength characteristic of the first optical device is different from a central wavelength characteristic of the second optical device.

3 . The optogenetic neural probe device of claim 1 , wherein the optical device group comprises a first optical device and a second optical device, and
wherein the first optical device comprises a light emitting element, and the second optical device comprises a light receiving element.

4 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port is configured to receive a fluorescent signal from a nerve cell, and to transmit the fluorescent signal to the optical waveguide, and
wherein the optical waveguide is configured to transmit the fluorescent signal to the optical device group.

5 . The optogenetic neural probe device of claim 1 , wherein the optical neural probe substrate is packaged on one side of the optical device alignment substrate.

6 . The optogenetic neural probe device of claim 1 , wherein the optogenetic neural probe comprises a plurality of shanks,
wherein each shank from among the plurality of shanks comprises a protrusion of the optical neural probe substrate, the optical waveguide, and the optical signal input/output port, and wherein the plurality of shanks are spaced apart from each other at a predetermined interval.

7 . The optogenetic neural probe device of claim 5 , wherein the optical neural probe substrate directly contacts the optical device group at a portion of the optical neural probe substrate that is packaged on the optical device alignment substrate,
wherein the portion comprises a recess structure including a step, and wherein a height of the step is equal to a height of the optical device group.

8 . The optogenetic neural probe device of claim 5 , wherein the optical device alignment substrate is coated with a fixing resin such that the optical neural probe substrate is fixed to the optical device alignment substrate.

9 . The optogenetic neural probe device of claim 8 , wherein the fixing resin comprises at least one from among a thermosetting resin and a photocurable resin.

10 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port is disposed at an end of the optical waveguide.

11 . The optogenetic neural probe device of claim 6 , wherein at least one shank from among the plurality of shanks comprises a plurality of optical signal input/output ports on the optical waveguide included in the at least one shank.

12 . The optogenetic neural probe device of claim 6 , wherein at least one shank from among the plurality of shanks comprises a plurality of optical waveguides.

13 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port comprises a diffraction grating.

14 . The optogenetic neural probe device of claim 1 , wherein the optical signal input/output port comprises a 45 degree mirror surface.

15 . The optogenetic neural probe device of claim 1 , wherein the optical device group comprises a plurality of optical device groups.

16 . A method of manufacturing an optogenetic neural probe device, the method comprising:
arraying a plurality of optogenetic neural probes using a fixing spacer; placing the plurality of optogenetic neural probes on an optical device alignment substrate on which a plurality of optical device groups are disposed; coating portions of a surface of the optical device alignment substrate contacting the plurality of optogenetic neural probes with a liquid fixing resin; and curing the fixing resin.

17 . The method of claim 16 , wherein each optogenetic neural probe from among the plurality of optogenetic neural probes comprises an optical neural probe substrate, an optical waveguide on the optical neural probe substrate, and an optical signal input/output port,
wherein an end of the optical neural probe substrate comprises a recess structure, and wherein the positioning of the plurality of optogenetic neural probes comprises placing the recess structure in contact with a corresponding optical device group from among the plurality of optical device groups and the optical device alignment substrate.

18 . An optical probe comprising:
at least one light emitter configured to emit an optical signal; an optical waveguide configured to provide an optical path of the optical signal; an optical signal input/output port configured to output the optical signal to an object; and an optical mode size converter provided between the at least one light emitter and the optical waveguide, wherein a cross-section area size of the optical mode size converter decreases in a direction from the least one light emitter toward the optical signal input/output port.

19 . The optical probe of claim 18 , wherein the optical signal input/output port is further configured to receive a response signal from the object, and
wherein the optical waveguide is further configured to provide an optical path of the response signal from the optical signal input/output port to the at least one light receiver.

20 . The optical probe of claim 19 , wherein the object is a nerve cell, and the response signal is a fluorescent signal emitted from the nerve cell as a result of stimulation of the nerve cell caused by the optical signal.

Assignees

• Electronics & Telecommunications Res Inst

Inventors

• Kwack Myungjoon
• Park Jaegyu
• Park Hyung Ju

Classifications

• A61B2562/12

  Manufacturing methods specially adapted for producing sensors for in-vivo measurements · CPC title

• A61N2005/063

  comprising light transmitting means, e.g. optical fibres · CPC title

• A61N2005/0612

  using probes penetrating tissue; interstitial probes · CPC title

• G02B6/4251

  Sealed packages (G02B6/4248 takes precedence) · CPC title

• G02B6/4295

  coupling with semiconductor devices activated by light through the light guide, e.g. thyristors, phototransistors · CPC title