Creating hydrogel films using a multilayered extrusion reactor apparatus

Patent metadata

Field	Value
Publication number	US-2024391153-A1
Application number	US-202418749620-A
Country	US
Kind code	A1
Filing date	Jun 21, 2024
Priority date	Dec 29, 2021
Publication date	Nov 28, 2024
Grant date	—

Abstract

Example methods and apparatus for creating a reaction product. An example method comprises flowing a first fluid in a flow direction in a first conduit in a multilayer extrusion reactor apparatus. The first fluid may be characterized by inertial forces dominating viscous forces of the first fluid. The method flows a second fluid in a flow direction in a second conduit in the apparatus. The first and second fluids may be miscible with one another. The method shapes the first and second conduits to provide an interface region between the first and second fluids. The method permits a reaction to create a reaction product in the interface region. The reaction product may mitigate flow-disrupting mixing between the first and second fluids.

First claim

What is claimed is:

1 . A method of moving materials to create a reaction product in a multilayer extrusion reactor apparatus, the method comprising:
flowing a first fluid in a flow direction in a first conduit in the apparatus, the first fluid characterized by inertial forces dominating viscous forces of the first fluid; flowing a second fluid in a flow direction in a second conduit in the apparatus, the first and second fluids miscible with one another; shaping the first and second conduits to provide an interface region between the first and second fluids; permitting a reaction to create a reaction product in the interface region, the reaction product mitigating flow-disrupting mixing between the first and second fluids.

2 . The method of claim 1 wherein flowing the first fluid in the flow direction comprises accelerating a velocity of the first fluid in the flow direction as the first fluid flows downstream in the flow direction.

3 . The method of claim 2 wherein accelerating the velocity of the first fluid in the flow direction as the first fluid flows downstream in the flow direction comprises providing a shape of the first conduit to have a cross-sectional area that decreases in the flow direction.

4 . The method of claim 1 wherein flowing the second fluid in the flow direction comprises accelerating a velocity of the second fluid in the flow direction as the second fluid flows downstream in the flow direction.

5 . The method of claim 4 wherein accelerating the velocity of the second fluid in the flow direction as the second fluid flows downstream in the flow direction comprises providing a shape of the second conduit to have a cross-sectional area that decreases in the flow direction.

6 . The method of claim 1 wherein the interface region is located at least in part in a third conduit and the method comprises accelerating a velocity of the reaction product in the flow direction as the reaction product flows downstream in the flow direction.

7 . The method of claim 6 wherein accelerating the velocity of the reaction product in the flow direction as the reaction product flows downstream in the flow direction comprises providing a shape of the third conduit to have a cross-sectional area that decreases in the flow direction.

8 . The method of claim 1 wherein the interface region is located at least in part in a third conduit and the method comprises flowing the reaction product with a constant velocity in the flow direction as the reaction product flows downstream in the flow direction.

9 . The method of claim 1 wherein the interface region is located at or downstream of a slice of the apparatus and the method comprises flowing the reaction product with a constant velocity in the flow direction as the reaction product flows downstream in the flow direction.

10 . The method of claim 1 wherein flowing the first fluid comprises creating a two-dimensional flow where the first fluid has a velocity with a lateral and longitudinal component prior to the interface region.

11 . The method of claim 1 wherein flowing the second fluid comprises creating a two-dimensional flow where the second fluid has a velocity with a lateral and longitudinal component prior to the interface region.

12 . The method of claim 1 further comprising flowing the reaction product such that the reaction product has a two-dimensional flow that has a velocity with a lateral and longitudinal component.

13 . The method of claim 1 further comprising positioning the apparatus to incline upwards such that a second longitudinal end of the apparatus is laterally located higher than a first longitudinal end of the apparatus.

14 . The method of claim 1 wherein creating the reaction product comprises creating the reaction product with a transverse dimension of 0.1 m to 10 m a lateral dimension of 0.1 cm to 30 cm at a rate in the longitudinal dimension of 0.1 m/s to 50 m/s.

15 . The method of claim 1 wherein creating the reaction product comprises creating the reaction product with a transverse dimension of 30 cm a lateral dimension of 0.5 mm at a rate in the longitudinal dimension of 20 cm/s or more.

16 . The method of claim 1 wherein one or both of the first fluid and the second fluid further comprise additives and aligning the additives by accelerating one or both of the first fluid and the second fluid.

17 . The method of claim 1 wherein creating the reaction product comprises strain hardening the reaction product.

18 . An apparatus for the creation of a reaction product, the apparatus comprising:
a first conduit comprising a rectangular transverse cross-sectional area, wherein the rectangular transverse cross-sectional area decreases downstream of a first longitudinal end; two or more vanes, each vane comprising a sheeted material, wherein each vane is positioned within the first conduit such that each vane extends the entire transverse dimension of the first conduit and at least a portion of the longitudinal dimension, wherein the two or more vanes create three or more sub-conduits within the first conduit that extend for at least a portion of the longitudinal dimension of the first conduit; two or more inner walls, each inner wall comprising a sheeted material running between a first vane and a second vane for at least a portion of the longitudinal dimension of the first conduit wherein each inner wall is attached to the first vane and the second vane; wherein one or more fluids are received at the first longitudinal end of the first conduit, flowed through the first conduit and expelled at a second longitudinal end.

19 . The apparatus of claim 18 wherein each of the two or more vanes comprise rigid material.

20 . The apparatus of claim 18 wherein at a transverse cross-section of the first conduit, the transverse dimension of the first conduit is at least 10 times the lateral dimension of the first conduit.

Assignees

• Univ British Columbia

Inventors

• Mackenzie Jordan
• Martinez Dominic Mark
• Younes Rami
• Buchen Michael

Classifications

• B29L2023/00

  Tubular articles (B29L2024/00 takes precedence {; catheters B29L2031/7542}) · CPC title

• B29K2105/16

  Fillers · CPC title

• B29K2105/0061

  Gel or sol · CPC title

• B29K2033/26

  Polymers of acrylamide or methacrylamide · CPC title

• B29C48/32

  with annular openings, e.g. for forming tubular articles · CPC title