Systems and methods for treating motor dysfunction, including by selectively activating and/or suppressing motor neurons and/or motor responses

Patent metadata

Field	Value
Publication number	US-2024390681-A1
Application number	US-202418664524-A
Country	US
Kind code	A1
Filing date	May 15, 2024
Priority date	Nov 15, 2021
Publication date	Nov 28, 2024
Grant date	—

Abstract

The present technology is directed generally to electrical stimulation and associated systems and methods for preferentially and/or selectively activating and suppressing motor neurons and/or motor responses, such as to treat a motor dysfunction in patients. For example, in some embodiments high frequency electrical stimulation can be administered to a target neural population via an implanted signal delivery device to induce a motor response in a first muscle, and low frequency electrical stimulation can be administered to the target neural population via the same signal delivery device to induce a motor response in a second muscle that is different than the first muscle.

First claim

1 . A method for inducing a motor response in a patient, comprising:
implanting a signal delivery device at a position proximate a target neural population in the patient, the target neural population including motor neurons associated with a first muscle and a second muscle; administering a first electrical signal to the target neural population via the signal delivery device to induce a motor response in the first muscle, the first electrical signal having a frequency in a frequency range of from 1.2 kHz to 100 KHz; and administering a second electrical signal to the target neural population via the signal delivery device to induce a motor response in the second muscle, the second electrical signal having a frequency of less than 1.2 KHz.

2 . The method of claim 1 wherein administering the first electrical signal preferentially induces a motor response in the first muscle relative to any motor response induced in the second muscle.

3 . The method of claim 1 wherein administering the first electrical signal induces a motor response in the first muscle without inducing a patient-detectable motor response in the second muscle.

4 . The method of claim 1 wherein administering the second electrical signal preferentially induces a motor response in the second muscle relative to any motor response induced in the first muscle.

5 . The method of claim 1 wherein administering the second electrical signal induces a motor response in the second muscle without inducing a patient-detectable motor response in the first muscle.

6 . The method of claim 1 wherein administering both the first electrical signal and the second electrical signal increases the overall motor response in the patient relative to administering only the first electrical signal or only the second electrical signal.

7 . The method of claim 1 wherein the signal delivery device includes at least one electrode, and wherein administering the first electrical signal and the second electrical signal includes administering the first electrical signal and the second electrical signal from the same at least one electrode.

8 . The method of claim 7 wherein the at least one electrode includes a pair of electrodes, and wherein the first electrical signal and the second electrical signal are administered via the same pair of electrodes.

9 . The method of claim 1 wherein the first electrical signal and the second electrical signal are administered without repositioning the signal delivery device.

10 . The method of claim 1 wherein the first electrical signal has a frequency in a frequency range of from about 5 kHz to about 15 kHz.

11 . The method of claim 1 wherein the first electrical signal has a frequency of about 10 KHz.

12 . The method claim 1 wherein the second electrical signal has a frequency of less than 100 Hz.

13 . The method of claim 1 wherein the second electrical signal has a frequency of less than 10 Hz.

14 . The method of claim 1 wherein the second electrical signal has a frequency of less than 1 Hz.

15 . The method of claim 1 wherein the patient is diagnosed with an indication characterized by motor dysfunction.

16 - 27 . (canceled)

28 . A method for treating a patient, comprising:
implanting a signal delivery device at a position proximate a target neural population in the patient, the target neural population including a first subset of motor neurons associated with a first muscle and a second subset of motor neurons associated with a second muscle; and selectively activating the first subset of motor neurons while simultaneously suppressing the second subset of motor neurons by administering an electrical signal to the target neural population via the signal delivery device, the electrical signal having a frequency in a frequency range of from 1.2 kHz to 100 KHz.

29 . The method of claim 28 wherein activating the first subset of motor neurons induces a patient-detectable motor response in the first muscle, and wherein suppressing the second subset of motor neurons inhibits any patient-detectable motor response in the second muscle.

30 . The method of claim 28 wherein the electrical signal has a frequency in a frequency range of from about 5 kHz to about 15 KHz.

31 . The method of claim 28 wherein the electrical signal has a frequency of about 10 KHz.

32 . The method of claim 28 wherein the second subset of motor neurons include spontaneously firing neurons, and wherein the electrical signal at least partially suppresses the spontaneously firing neurons.

33 . The method of claim 28 wherein the patient is diagnosed with an indication characterized by motor dysfunction.

34 . A method for treating a patient, comprising:
programming a signal generator to:
administer a first electrical signal to a target neural population via an implanted signal delivery device, the target neural population including motor neurons associated with a first muscle and a second muscle, wherein the first electrical signal has a frequency in a frequency range of from 1.2 kHz to 100 kHz, and wherein the first electrical signal induces a motor response in the first muscle; and
administer a second electrical signal to the target neural population via the implanted signal delivery device, wherein the second electrical signal has a frequency of less than 1.2 kHz, and wherein the second electrical signal induces a motor response in the second muscle.

35 . A patient treatment system, comprising:
a signal delivery device configured to be implanted at a position proximate a target neural population in the patient, the target neural population including motor neurons associated with a first muscle and a second muscle; and a signal generator having a computer readable storage medium with instructions that, when executed, cause the signal generator to:
deliver a first electrical signal to the target neural population via the signal delivery device to induce a motor response in the first muscle, the first electrical signal having a frequency in a frequency range of from 1.2 kHz to 100 kHz; and
deliver a second electrical signal to the target neural population via the signal delivery device to induce a motor response in the second muscle, the second electrical signal having a frequency less than 1.2 KHz.

Assignees

• Nevro Corp

Inventors

• Lee Dongchul
• Lee Kwan Yeop

Classifications

• A61N1/37217

  characterised by the communication link, e.g. acoustic or tactile · CPC title

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61N1/36062

  Spinal stimulation · CPC title

• A61N1/36171 Primary

  Frequency · CPC title

• A61N1/36067 Primary

  Movement disorders, e.g. tremor or Parkinson disease (stimulating motor muscle A61N1/36003) · CPC title