Apparatus for measuring glycation of red blood cells and glycated hemoglobin level using physical and electrical characteristics of cells, and related methods
US-12013404-B2 · Jun 18, 2024 · US
US2024377354A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2024377354-A1 |
| Application number | US-202418611311-A |
| Country | US |
| Kind code | A1 |
| Filing date | Mar 20, 2024 |
| Priority date | May 9, 2023 |
| Publication date | Nov 14, 2024 |
| Grant date | — |
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Circuitry for measuring a characteristic of a sensor having a reactive impedance, the circuitry comprising: a first integrator having a first integrator input, a first integrator output, and an integrating element coupled between the first integrator input and the first integrator output, the integrating element comprising the sensor; And processing circuitry configured to: determine a state of the sensor based on an output signal derived from the first integrator output.
Opening claim text (preview).
1 . Circuitry for measuring a characteristic of a sensor having a reactive impedance, the circuitry comprising: a first integrator having a first integrator input, a first integrator output, and an integrating element coupled between the first integrator input and the first integrator output, the integrating element comprising the sensor; and processing circuitry configured to: determine a state of the sensor based on an output signal derived from the first integrator output. 2 . The circuitry of claim 1 , wherein the state of the sensor comprises a characteristic of the sensor. 3 . The circuitry of claim 2 , wherein the processing circuitry is configured to: low-pass filter the output signal to determine a first aspect of the state of the sensor. 4 . The circuitry of claim 1 , wherein the processing circuitry is configured to: high-pass filter the output signal to determine a second aspect of the state of the sensor. 5 . The circuitry of claim 1 , wherein the processing circuitry is configured to: band-pass filter the output signal to determine a third aspect of the state of the sensor at one or more band-pass frequencies defined by the band-pass filtering. 6 . The circuitry of claim 1 , wherein the processing circuitry is configured to: apply a Fourier transform to the output signal to determine the state of the sensor as a function of frequency. 7 . The circuitry of claim 1 , wherein, during derivation of the output signal, the processing circuitry is configured to hold first and second electrodes of the sensor at first and second predetermined voltages. 8 . The circuitry of claim 1 , wherein the sensor is a capacitive sensor or an inductive sensor. 9 . (canceled) 10 . The circuitry of claim 1 , comprising: an analog-to-digital converter (ADC), comprising: an ADC output configured to output the output signal; and the first integrator. 11 . (canceled) 12 . The circuitry of claim 10 , comprising: a digital-to-analog converter (DAC) provided in a feedback path between the ADC output and the first integrator input. 13 . The circuitry of claim 1 , wherein the processing circuitry is configured to: derive a noise transfer function of the ADC from the output signal; and determine the state of the sensor based on the noise transfer function. 14 . The circuitry of claim 12 , wherein the ADC comprises a quantizer comprising a quantiser input coupled to the first integrator output and a quantiser output coupled to the ADC output, wherein the quantiser is configured to derive the output signal based on the first integrator input. 15 .- 16 . (canceled) 17 . The circuitry of claim 14 , further comprising control circuitry configured to adapt a hysteresis of the comparator based on a limit cycle frequency or limit cycle period of the first quantizer output. 18 . The circuitry of claim 14 , wherein the quantizer is a multi-bit quantiser and wherein the DAC comprises a finite impulse response DAC. 19 . The circuitry of claim 10 , further comprising dither circuitry configured to add noise at one or more of: the first integrator input; the ADC output; the first integrator output; and the feedback path between the ADC input and the ADC output. 20 . The circuitry of claim 14 , further comprising a second integrator having a second integrator input coupled to the first integrator output and a second integrator output coupled to the quantiser input. 21 . The circuitry of claim 1 , wherein the sensor comprises an electrochemical cell. 22 . (canceled) 23 . Circuitry of claim 21 , wherein the electrochemical cell comprises a potentiostat comprising at least one working electrode and at least one counter electrode, wherein the at least one counter electrode is coupled to the first integrator input and the at least one working electrode is coupled to the first integrator output. 24 . (canceled) 25 . Circuitry of claim 21 , wherein the electrochemical cell comprises a potentiostat comprising at least one working electrode, at least one counter electrode, and a reference electrode, wherein the reference electrode is coupled to the first integrator input and the at least one working electrode is coupled to the first integrator output. 26 .- 27 . (canceled) 28 . Circuitry of claim 21 , wherein the electrochemical cell comprises a battery comprising an anode coupled to the first integrator input and a cathode coupled to the first integrator output. 29 . Circuitry for measuring a characteristic of a sensor having a reactive impedance, the circuitry comprising: a first integrator having a first integrator input, a first integrator output, and an integrating element coupled between the first integrator input and the first integrator output, the integrating element comprising the sensor; and processing circuitry configured to decode an output signal derived from the first integrator output to determine a state of the sensor. 30 . Circuitry comprising: a sensor having a reactive impedance; the sensor arranged as an integrating element of the circuitry; wherein an integrated output of the integrating element is decoded to determine a state of the sensor. 31 . An electronic device, comprising the circuitry of claim 1 , wherein the device comprises one of a continuous glucose monitor, a wearable device, a medical device, an augmented reality headset, a virtual reality headset, a mobile computing device, a laptop computer, a tablet computer, a games console, a remote control device, a home automation controller, a domestic appliance, a toy, a robot, an audio player, a video player, a mobile telephone, and a smartphone. 32 .- 33 . (canceled)
Circuits therefor (measuring impedance per se G01R27/02) · CPC title
Devices therefor, e.g. test element readers, circuitry (details not specific to biochemical electrodes G01N33/4875) · CPC title
for measuring glucose, e.g. by tissue impedance measurement · CPC title
Details of analogue processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation (input circuits for detecting, measuring, or recording bioelectric or biomagnetic signals A61B5/30; specific diagnostic methods using bioelectric or biomagnetic signals A61B5/316) · CPC title
Cells and electrode assemblies · CPC title
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