Anion sensing using 1,2,3-triazolate metal-organic framework nanoparticles

Patent metadata

Field	Value
Publication number	US-2024369507-A1
Application number	US-202418653828-A
Country	US
Kind code	A1
Filing date	May 2, 2024
Priority date	May 3, 2023
Publication date	Nov 7, 2024
Grant date	—

Abstract

Disclosed herein are aspects of a method for sensing anions using 1,2,3-triazolate metal-organic frameworks (MOFs). In certain aspects, the method exposes an electrochemical anion sensor to a sample, wherein the electrochemical anion sensor comprises an electrode functionalized with a conductive porous film comprising a plurality of crystalline metal organic framework (MOF) nanoparticles, and a potential is applied to the electrode. Also disclosed herein are aspects of an electrochemical analyte sensor comprising a working electrode functionalized with a plurality of MOF nanoparticles, a counter electrode, and a reference electrode.

First claim

We claim:

1 . A method, comprising:
exposing an electrochemical anion sensor to a sample, wherein the electrochemical anion sensor comprises an electrode functionalized with a conductive porous film comprising a plurality of crystalline metal organic framework (MOF) nanoparticles having a pore size ranging from greater than 4.5 Å to less than 10 Å; and applying a potential to the electrode.

2 . The method of claim 1 , further comprising measuring a signal produced by one or more anions present in the sample to thereby detect the presence and/or identity of the one or more anions.

3 . The method of claim 2 , wherein the one or more anions independently have a diameter ranging from 1 Å to 10 Å.

4 . The method of claim 2 , wherein the one or more anions are independently selected from halide anions, perhalogenated anions, oxyanions, nitrile-containing anions, or any combination thereof.

5 . The method of claim 4 , wherein the one or more halide anions are selected from F − , Cl − , I − , Br − , or any combination thereof.

6 . The method of claim 4 , wherein the one or more perhalogenated anions are selected from BF 4 − , PF 6 − , OTf − , CF 3 SO 3 − , CF 3 SO 2 NH − , or any combination thereof.

7 . The method of claim 4 , wherein the one or more nitrile-containing anions are C 2 N 3 − .

8 . The method of claim 4 , wherein the one or more oxyanions comprise a halogen, sulfate, phosphate, or nitrate.

9 . The method of claim 8 , wherein the one or more oxyanions are ClO 4 − .

10 . The method of claim 2 , wherein the potential is a varying potential and the signal is detected as an intercalation potential.

11 . The method of claim 2 , wherein the potential is a fixed potential and the signal is detected as a change in current.

12 . The method of claim 2 , wherein a detected concentration of the one or more anions in the sample ranges from 1 nanomolar to 1 molar.

13 . The method of claim 2 , wherein the one or more anions comprise a first anion species and a second ion species, and wherein the first anion species is different from the second anion species.

14 . The method of claim 13 , wherein the one or more anions further comprise a third anion species, and wherein the third anion species is different from the first anion species and the second anion species.

15 . The method of claim 2 , further comprising applying a negative voltage to de-intercalate the one or more anions from pores of the MOF nanoparticles.

16 . The method of claim 1 , wherein the MOF nanoparticles have a polydispersity index value ranging from a value greater than 0 to a value less than 0.4.

17 . An electrochemical analyte sensor, comprising:
a working electrode functionalized with a plurality of crystalline metal-organic framework (MOF) nanoparticles having a pore size ranging from greater than 4.5 Å to less than 10 Å; a counter electrode; and a reference electrode.

18 . The electrochemical analyte sensor of claim 17 , further comprising a control unit comprising:
(i) a power component for applying an electrical potential to the working electrode; and/or (ii) a measuring component for measuring a voltage and/or a current.

19 . The electrochemical analyte sensor of claim 17 , further comprising an electrolyte-containing solution comprising one or more cations, wherein the electrolyte-containing solution is an organic solution or an aqueous solution.

20 . The electrochemical analyte sensor of claim 18 , wherein (i) the power component is selected from a power supply, a voltage supply, a potentiostat, or any combination thereof; and wherein (ii) the measuring component is selected from a voltmeter, a potentiometer, an ammeter, a resistometer, or any combination thereof.

21 . A method of using the electrochemical analyte sensor of claim 17 , the method comprising:
exposing the electrochemical analyte sensor to a liquid sample; and applying a varying potential between the working electrode and the counter electrode.

22 . The method of claim 21 , further comprising measuring an intercalation potential associated with intercalation of one or more anions with the Cr(1,2,3-triazolate) 2 MOF nanoparticles, wherein the one or more anions are selected from F − , I − , Cl − , or B − , BF 4 − , ClO 4 − , PF 6 − , OTf − , C 2 N 3 − , CF 3 SO 2 NH − , or any combination thereof.

Assignees

• Univ Oregon

Inventors

• Brozek Carl
• Huang Jiawei

Classifications

• G01N27/30 Primary

  Electrodes, e.g. test electrodes; Half-cells (G01N27/414 takes precedence) · CPC title

• G01N27/333

  Ion-selective electrodes or membranes (glass electrodes G01N27/36) · CPC title

• C07F15/025

  without a metal-carbon linkage · CPC title

• C07F11/005

  compounds without a metal-carbon linkage · CPC title