Vena caval occlusion

Patent metadata

Field	Value
Publication number	US-2024359001-A1
Application number	US-202418767628-A
Country	US
Kind code	A1
Filing date	Jul 9, 2024
Priority date	Nov 23, 2016
Publication date	Oct 31, 2024
Grant date	—

Abstract

Apparatus and methods are described including reducing cardiac preload of a subject by partially occluding a vena cava of the subject at an infra-renal location. One or more physiological parameters of the subject are monitored, the one or more physiological parameters including lower body venous pressure, central venous pressure, central venous blood flow, renal venous pressure, cardiac diameter, cardiac volume, arterial pressure, and/or arterial blood flow. An extent to which the vena cava is occluded at the infra-renal location is modulated, responsively to the one or more physiological parameters. Other applications are also described.

First claim

1 . An apparatus, comprising:
an occlusion element configured to reduce cardiac preload of a subject by being placed in a vena cava of the subject at an infra-renal location, and to partially occlude the subject's vena cava at the infra-renal location; one or more sensors configured to monitor one or more physiological parameters of the subject selected from the group consisting of: lower body venous pressure, central venous pressure, central venous blood flow, renal venous pressure, cardiac diameter, cardiac volume, arterial pressure, and arterial blood flow; and a computer processor configured to modulate an extent to which the occlusion element occludes the vena cava at the infra-renal location, responsively to the one or more physiological parameters.

2 . The apparatus according to claim 1 , wherein the occlusion element comprises a balloon configured to be inflated at the infra-renal location, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location by modulating an extent to which the balloon is inflated.

3 . The apparatus according to claim 1 , wherein the occlusion element comprises an expandable frame having material covered thereto, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location by modulating an extent to which the frame is expanded.

4 . The apparatus according to claim 1 , wherein the occlusion element comprises a nozzle, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location by modulating a diameter of an opening of the nozzle.

5 . The apparatus according to claim 1 , wherein the one or more sensors are configured to monitor a parameter of the subject that is indicative of cardiac output of the subject, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location responsively to the parameter that is indicative of the cardiac output.

6 . The apparatus according to claim 5 , wherein the one or more sensors comprise a thermodilution catheter configured to monitor the parameter that is indicative of the cardiac output.

7 . The apparatus according to claim 5 , wherein the one or more sensors are further configured to monitor a parameter of the subject that is indicative of cardiac preload of the subject, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location responsively to the parameter that is indicative of the cardiac output in combination with the parameter that is indicative of the cardiac preload.

8 . The apparatus according to claim 1 , wherein the one or more sensors are configured to monitor a parameter of the subject that is indicative of arterial blood pressure of the subject, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location responsively to the parameter that is indicative of the arterial blood pressure.

9 . The apparatus according to claim 8 , wherein the one or more sensors are further configured to monitor a parameter of the subject that is indicative of cardiac preload of the subject, and wherein the computer processor is configured to modulate the extent to which the occlusion element occludes the vena cava at the infra-renal location responsively to the parameter that is indicative of the arterial blood pressure in combination with the parameter that is indicative of the cardiac preload.

10 . The apparatus according to claim 1 , further comprising a blood pump configured to be placed at a location within the vena cava that is downstream of junctions of the vena cava with all renal veins of the subject, the blood pump being configured to reduce the subject's renal venous pressure relative to the subject's central venous pressure by pumping blood in an antegrade direction through the vena cava from the location.

11 . The apparatus according to claim 10 , wherein the computer processor is further configured to modulate a rate at which the blood pump pumps blood in the antegrade direction, responsively to the one or more physiological parameters.

12 . The apparatus according to claim 11 , wherein the computer processor is configured to modulate the rate at which the blood pump pumps blood in the antegrade direction responsively to the one or more physiological parameters in coordination with modulating the extent to which the vena cava is occluded at the infra-renal location responsively to the one or more physiological parameters, such as to:
maintain a first ratio between the subject's renal venous pressure and the subject's lower body venous pressure, and maintain a second ratio between the subject's central venous pressure and the subject's lower body venous pressure, the second ratio being different from the first ratio.

13 . A method, comprising:
reducing cardiac preload of a subject by partially occluding a vena cava of the subject at an infra-renal location; monitoring one or more physiological parameters of the subject selected from the group consisting of: lower body venous pressure, central venous pressure, central venous blood flow, renal venous pressure, cardiac diameter, cardiac volume, arterial pressure, and arterial blood flow; and modulating an extent to which the vena cava is occluded at the infra-renal location, responsively to the one or more physiological parameters.

14 . The method according to claim 13 , wherein partially occluding the subject's vena cava at the infra-renal location comprises inflating a balloon at the infra-renal location, and wherein modulating an extent to which the vena cava is occluded at the infra-renal location comprises modulating an extent to which the balloon is inflated.

15 . The method according to claim 13 , wherein partially occluding the subject's vena cava at the infra-renal location comprises placing an expandable frame having material covered thereto at the infra-renal location and expanding the expandable frame, and wherein modulating an extent to which the vena cava is occluded at the infra-renal location comprises modulating an extent to which the frame is expanded.

16 . The method according to claim 13 , wherein partially occluding the subject's vena cava at the infra-renal location comprises placing a nozzle at the infra-renal location, and wherein modulating an extent to which the vena cava is occluded at the infra-renal location comprises modulating a diameter of an opening of the nozzle.

17 . The method according to claim 13 , wherein monitoring the one or more physiological parameters comprises monitoring a parameter that is indicative of cardiac output of the subject, and wherein modulating an extent to which the vena cava is occluded at the infra-renal location comprises modulating an extent to which the vena cava is occluded at the infra-renal location responsively to the parameter that is indicative of the cardiac output.

18 . The method according to claim 17 , wherein monitoring the parameter that is indicative of the cardiac output comprises using a thermodilution catheter to monitor the parameter that is indicative of the cardiac output.

19 . The method according to claim 17 , wherein monitoring the one or more physiological parameters furth

Assignees

• Magenta Medical Ltd

Inventors

• Tuval Yosi
• Schwammenthal Ehud
• Glozman Daniel
• Lubinsky Gad

Classifications

• A61M60/139

  inside the aorta, e.g. intra-aortic balloon pumps · CPC title

• A61M60/531

  using blood pressure data, e.g. from blood pressure sensors · CPC title

• A61M60/585

  User interfaces · CPC title

• A61M60/818

  Bearings · CPC title

• A61M60/804

  Impellers · CPC title