Sensor systems, devices, and methods for continuous glucose monitoring

Patent metadata

Field	Value
Publication number	US-2024345011-A1
Application number	US-202418735347-A
Country	US
Kind code	A1
Filing date	Jun 6, 2024
Priority date	Dec 28, 2015
Publication date	Oct 17, 2024
Grant date	—

Abstract

A method of optimizing operation of a glucose sensor includes performing an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for an electrode of a glucose sensor, calculating a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value, and obtaining measurements of the calibration factor for the glucose sensor. The method also includes comparing the change value to a first threshold and the calibration factor to a second threshold and determining, based on the comparison, whether sensor data from the glucose sensor is valid.

First claim

1 - 11 . (canceled)

12 . A method of optimizing operation of a glucose sensor, said glucose sensor including physical sensor electronics, a microcontroller, and a working electrode, the method comprising:
(a) performing, by said microcontroller, an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for said electrode; (b) calculating, by said sensor electronics, a change value as a difference between a threshold reference for said imaginary impedance values and a most-recent imaginary impedance value; (c) obtaining, by said microcontroller, measurements of the calibration factor for said glucose sensor; (d) comparing, by said microcontroller, said change value to a first threshold and said calibration factor to a second threshold; (e) based on said comparison, determining, by said microcontroller, whether sensor data from said glucose sensor is valid; and (f) continuing, by said microcontroller, to operate the glucose sensor if said sensor data is valid, and terminating the glucose sensor, by said microcontroller, if said sensor data is invalid.

13 . The method of claim 12 , wherein the sensor data is determined to be valid if either the calibration factor is less than the second threshold or the change value is less than the first threshold for two consecutive measurements of the change value.

14 . The method of claim 12 , further comprising terminating the glucose sensor if the change value is greater than the first threshold for two consecutive calculations of the change value, and the calibration factor is greater than said second threshold.

15 . The method of claim 12 , wherein said change value is calculated as the absolute difference between the threshold reference and the most-recent imaginary impedance value.

16 . The method of claim 12 , wherein said imaginary impedance values are 8 kHz imaginary impedance values.

17 . The method of claim 12 , wherein said threshold reference is calculated as an 8 kHz imaginary impedance value.

18 . The method of claim 17 , wherein said threshold reference is clipped so as to fall within a range from about −1,000Ω to about 800Ω.

19 . The method of claim 12 , wherein the sensor includes a plurality of working electrodes, and steps (a)-(f) are performed for each of the plurality of electrodes.

20 . The method of claim 12 , wherein said first threshold value is 1,200Ω and said second threshold value is 14 mg/dL/nA.

21 . A method of optimizing operation of a glucose sensor, the method comprising:
performing, by a microcontroller of the glucose sensor, an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for a working electrode of the glucose sensor; calculating, by the microcontroller of the glucose sensor, a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value; obtaining, by the microcontroller of the glucose sensor, measurements of a calibration factor for the glucose sensor; comparing, by the microcontroller of the glucose sensor, the change value to a first threshold and the calibration factor to a second threshold; and based on the comparison, determining, by the microcontroller of the glucose sensor, whether sensor data from the glucose sensor is valid.

22 . The method of claim 21 , further comprising continuing to operate the glucose sensor if the sensor data is valid and terminating the glucose sensor if the sensor data is invalid.

23 . The method of claim 21 , further comprising determining that the sensor data is valid if either the calibration factor is less than the second threshold or the change value is less than the first threshold for two consecutive calculations of the change value.

24 . The method of claim 21 , further comprising terminating the glucose sensor if the change value is greater than the first threshold for two consecutive calculations of the change value, and the calibration factor is greater than said second threshold.

25 . The method of claim 21 , further comprising calculating the change value as the absolute difference between the threshold reference and the most-recent imaginary impedance value.

26 . One or more non-transitory processor readable media storing instructions which, when executed by one or more processors, cause performance of:
performing an electrochemical impedance spectroscopy (EIS) procedure to obtain imaginary impedance values for a working electrode of a glucose sensor; calculating a change value as a difference between a threshold reference for the imaginary impedance values and a most-recent imaginary impedance value; comparing the change value to a first threshold and the calibration factor to a second threshold; and determining, based on the comparison, whether sensor data from the glucose sensor is valid.

27 . The one or more non-transitory processor-readable media of claim 26 , wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of obtaining measurements of the calibration factor for the glucose sensor.

28 . The one or more non-transitory processor-readable media of claim 26 , wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of continuing to operate the glucose sensor if the sensor data is valid and terminating the glucose sensor if the sensor data is invalid.

29 . The one or more non-transitory processor-readable media of claim 26 , wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of determining that the sensor data is valid if either the calibration factor is less than the second threshold or the change value is less than the first threshold for two consecutive calculations of the change value.

30 . The one or more non-transitory processor-readable media of claim 26 , wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of terminating the glucose sensor if the change value is greater than the first threshold for two consecutive calculations of the change value, and the calibration factor is greater than the second threshold.

31 . The one or more non-transitory processor-readable media of claim 26 , wherein the one or more non-transitory processor-readable media store further instructions which, when executed by the one or more processors, cause performance of calculating the change value as the absolute difference between the threshold reference and the most-recent imaginary impedance value.

Assignees

• Medtronic Minimed Inc

Inventors

• Nogueira Keith
• Engel Taly G
• Li Xiaolong
• Liang Bradley C
• Shah Rajiv
• Kim Jaeho
• Liu Mike C
• Tsai Andy Y
• Varsavsky Andrea
• Yu Fei

Classifications

• G01N33/48707

  by electrical means (G01N33/49, G01N33/493 take precedence) · CPC title

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• G01N27/30

  Electrodes, e.g. test electrodes; Half-cells (G01N27/414 takes precedence) · CPC title

• G01N27/026 Primary

  Dielectric impedance spectroscopy (electrochemical impedance spectroscopy for measuring corrosion G01N17/02) · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title