Methods, systems, and devices for analyzing lung imaging data to determine collateral ventilation

Patent metadata

Field	Value
Publication number	US-2024331154-A1
Application number	US-202418738796-A
Country	US
Kind code	A1
Filing date	Jun 10, 2024
Priority date	Aug 6, 2020
Publication date	Oct 3, 2024
Grant date	—

Abstract

Devices, methods, and systems are provided for analyzing lung imaging data. Lung imaging data maybe analyzed to segment the lung, identify fissure locations, calculate fissure defect scores, identify adjacent lung compartments, calculate emphysema scores, calculate volumes, and calculate proximities. Collateral ventilation within a lung compartment may be determined based on the analyzed lung imaging data.

First claim

What is claimed is:

1 . A method of assessing collateral ventilation in a lung of a patient, the method comprising:
analyzing computerized tomography data of a lung, wherein analyzing the computerized tomography data comprises:
segmenting the lung into separate lung compartments;
identifying a fissure defect;
identifying lung compartments adjacent to the fissure defect;
determining changes in volumes of a first lung compartment adjacent to the fissure defect and second lung compartment adjacent to the fissure defect on an opposing side of the fissure defect during breathing; and
determining whether collateral ventilation is present or above a threshold level in the first or second lung compartment based on the changes in volumes of the first and second lung compartments.

2 . The method of claim 1 , wherein collateral ventilation is determined to be present or above a threshold level if the first and second lung compartments inflate or deflate asynchronously during breathing.

3 . The method of claim 1 , further comprising calculating a fissure defect score based on a size of the fissure defect.

4 . The method of claim 3 , wherein determining whether collateral ventilation is present or above a threshold level is further based on the calculated defect score.

5 . The method of claim 4 , further comprising determining a degree of collateral ventilation based on the changes in volumes of the first and second lung compartments.

6 . The method of claim 1 , further comprising creating a report indicating lung compartments determined to have collateral ventilation or degrees of collateral ventilation for lung compartments.

7 . The method of claim 6 , wherein the report comprises one or more potential treatment sites and one or more suggested implantable devices for the potential treatment site to cause lung volume reduction or reduce hyperinflation.

8 . The method of claim 7 , wherein the first or second lung compartment is determined not to have collateral ventilation or a degree of collateral ventilation below a threshold level and the potential treatment site is an airway leading to the first or second lung compartment.

9 . The method of claim 8 , wherein the one or more suggested implantable devices comprises an endobronchial valve, clip, or plug.

10 . The method of claim 8 , wherein the one or more suggested implantable devices comprises a one-way flow control valve configured to allow airflow out of the lung compartment and prevent airflow into the lung compartment to cause lung volume reduction or reduce hyperinflation.

11 . The method of claim 6 , wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to cause lung volume reduction or reduce hyperinflation.

12 . The method of claim 11 , wherein the first or second lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises one or more regions within the first or second lung compartment.

13 . The method of claim 12 , wherein the one or more suggested therapeutic agents comprises a sealant.

14 . The method of claim 12 , wherein the one or more suggested implantable devices comprises an endobronchial valve, clip, or plug.

15 . The method of claim 6 , wherein the report comprises one or more potential treatment sites and one or more suggested therapeutic agents or implantable devices to be delivered to the potential treatment site to minimize collateral ventilation between lung compartments.

16 . The method of claim 15 , wherein the first or second lung compartment is determined to have collateral ventilation or a degree of collateral ventilation above a threshold level and the potential treatment site comprises an airway leading to the fissure defect.

17 . The method of claim 16 , wherein the one or more suggested therapeutic agents comprises a sealant.

18 . The method of claim 16 , wherein the one or more suggested implantable devices comprises an endobronchial valve, clip, or plug.

19 . A method of assessing collateral ventilation in a lung of a patient, the method comprising:
analyzing computerized tomography data of a lung, wherein analyzing the computerized tomography data comprises:
segmenting the lung into separate lobes;
segmenting at least one of the separate lobes into a plurality of lung segments;
identifying a fissure defect;
identifying one or more lung segments of the plurality of lung segments adjacent to the fissure defect;
determining changes in volumes of a first lung segment adjacent to the fissure defect and second lung segment adjacent to the fissure defect on an opposing side of the fissure defect during breathing;
determining whether collateral ventilation is present or above a threshold level in the first or second lung segment based on the changes in volumes of the first and second lung segments.

20 . The method of claim 19 , further comprising calculating a fissure defect score based on a size of the fissure defect, wherein determining whether collateral ventilation is present or above a threshold level is further based on the calculated defect score.

Assignees

• Pulmonx Corp

Inventors

• Radhakrishnan Sri
• Olivera Ryan

Classifications

• G16H50/30

  for calculating health indices; for individual health risk assessment · CPC title

• G06T2207/10081

  Computed x-ray tomography [CT] · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title

• G06T7/11

  Region-based segmentation · CPC title

• G16H50/20

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title