Method and system for determining cardiac abnormalities using chaos-based classification model from multi-lead ecg

Patent metadata

Field	Value
Publication number	US-2024321450-A1
Application number	US-202318393358-A
Country	US
Kind code	A1
Filing date	Dec 21, 2023
Priority date	Mar 21, 2023
Publication date	Sep 26, 2024
Grant date	—

Abstract

Improvement in the accuracy of disease diagnosis associated with cardiac abnormalities is an open research area. Appropriate feature selection to capture the underlying signs of a disease is critical in Machine Learning (ML) based approaches. A method and system for, determining cardiac abnormalities using chaos-based classification model from multi-lead ECG signals, is disclosed. The method combines the commonly used chaos parameter with other set of chaos-related statistical parameters like non-linearity, self-similarity, Chebyshev distance and spectral flatness for a holistic approach to the study of cardiac abnormalities. The method disclosed thus attempts to use above ML based measures for disease classification. The set of chaos-related features used herein contribute to improving the accuracy of detection of various cardiac diseases arising due to cardiac abnormalities such as Atrial Fibrillation (AF) and the like. The improved accuracy in the detection of AF effectively improves the accuracy in percentage of AF burden.

First claim

What is claimed is:

1 . A processor implemented method for determining cardiac abnormalities, the method comprising:
segmenting via one or more hardware processors, time series data associated with multi-lead electrocardiogram (ECG) signals captured for each of a plurality of subjects, into a plurality of overlapping windows; decomposing via the one or more hardware processors, the time series data associated with each of the plurality of overlapping windows to generate raw (RAW) data comprising windowed decomposed time series; applying via the one or more hardware processors, de-trending and de-seasonalizing on the windowed decomposed time series data to generate Trend and Seasonally Adjusted (TSA) data; deriving via the one or more hardware processors, a plurality of features from at least one of the RAW data and the TSA data, wherein the plurality of features comprising:
a chaos feature for the RAW data providing a uni-dimensional measure of the cardiac abnormalities present in each windowed decomposed time series;
a set of chaos-related statistical features comprising, i) a non-linearity feature and a Chebyshev distance feature for the RAW data and the TSA data, and ii) a spectral flatness feature and a self-similarity feature for the RAW data, to add multiple dimensions to the chaos feature for generating a holistic view of the cardiac abnormalities; and
a set of statistical features comprising, i) a serial correlation feature, a skewness feature and a kurtosis feature for the RAW data and the TSA data, ii) a trend feature and a seasonality feature for the TSA data, and iii) a periodicity feature for the RAW data, providing statistical distribution of the cardiac abnormalities;
identifying via the one or more hardware processors, a set of significant features from among the plurality of features using a feature importance technique; and training via the one or more hardware processors, a chaos-based classification model on the set of significant features derived for each of the plurality of subject to classify the plurality of subjects into one of an abnormal class and a normal class.

2 . The processor implemented method as claimed in claim 1 comprising utilizing the trained chaos-based classification model during an inferencing stage to classify an unseen subject into one of the normal class and the abnormal class in accordance with the set of significant features derived from the multi-lead ECG signal recorded for the unseen subject for a predefined duration of an ECG recording by segmenting the ECG recording into the plurality of overlapping windows, wherein the abnormal class indicates the unseen subject suffering from Atrial Fibrillation (AF), and the normal class indicates the unseen subject to be healthy with Sinus Rhythm.

3 . The processor implemented method as claimed in claim 2 comprising computing percentage AF burden (AFB %) for the unseen subject, wherein

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and wherein, D AF is duration of the AF, DT is a predefined duration of the ECG recording, N AF is the number of AF windows detected for the unseen subject during the predefined duration of the ECG recording, AF Avg is an average of an AF time over the plurality of overlapping windows of the ECG recording, and D Ovip is the AF time in the plurality of overlapping windows of the ECG recording, which is 50% of the AF Avg .

4 . The processor implemented method as claimed in claim 1 , wherein each of the plurality of overlapping windows has a window period of 3 sec.

5 . The processor implemented method as claimed in claim 1 , wherein the chaos-based classification model is trained on the set of significant features derived for each of the plurality of subject to classify the plurality of subjects into one of the abnormal class indicating Ventricular Fibrillation (VF) and the normal class indicating Sinus Rhythm.

6 . The processor implemented method as claimed in claim 1 , wherein the chaos-based classification model is trained on the set of significant features derived for each of the plurality of subject to classify the plurality of subjects into one of the abnormal class indicating Sinus Arrhythmia and the normal class indicating Sinus Rhythm.

7 . A system for determining cardiac abnormalities, the system comprising:
a memory storing instructions; one or more Input/Output (I/O) interfaces; and one or more hardware processors coupled to the memory via the one or more I/O interfaces, wherein the one or more hardware processors are configured by the instructions to:
segment time series data associated with multi-lead electrocardiogram (ECG) signals captured for each of a plurality of subjects, into a plurality of overlapping windows;
decompose the time series data associated with each of the plurality of overlapping windows to generate raw (RAW) data comprising windowed decomposed time series;
apply de-trending and de-seasonalizing on the windowed decomposed time series data to generate Trend and Seasonally Adjusted (TSA) data;
derive a plurality of features from at least one of the RAW data and the TSA data,

Assignees

• Tata Consultancy Services Ltd

Inventors

• Sharma Varsha
• Ghose Avik
• Khandelwal Sundeep
• Bhattacharya Sakyajit

Classifications

• A61B5/7271

  Specific aspects of physiological measurement analysis (specific diagnostics methods using bioelectric or biomagnetic signals A61B5/316) · CPC title

• A61B5/72

  Signal processing specially adapted for physiological signals or for diagnostic purposes · CPC title

• A61B5/361

  Detecting fibrillation · CPC title

• A61B5/349

  Detecting specific parameters of the electrocardiograph cycle · CPC title

• A61B5/318 Primary

  Heart-related electrical modalities, e.g. electrocardiography [ECG] · CPC title