Adhesion prevention with shear-thinning polymeric hydrogels

Patent metadata

Field	Value
Publication number	US-2024299632-A1
Application number	US-202418608675-A
Country	US
Kind code	A1
Filing date	Mar 18, 2024
Priority date	Apr 3, 2017
Publication date	Sep 12, 2024
Grant date	—

Abstract

A method of preventing tissue adhesion includes forming an incision in tissue, applying a hydrogel to tissue through the incision, and closing the incision with the hydrogel therein. The hydrogel includes a polymer non-covalently cross-linked with a plurality of nanoparticles and prevents a formation of adhesions between tissues and/or organs.

First claim

1 . A method comprising:
applying a supramolecular hydrogel to a tissue, the supramolecular hydrogel comprising a hydrophobically modified cellulose derivative non-covalently cross-linked with a plurality of nanoparticles; and inhibiting formation of an adhesion on the tissue with the applied supramolecular hydrogel.

2 . The method of claim 1 , wherein the supramolecular hydrogel comprises from 5 wt % to 10 wt % of the nanoparticles.

3 . The method of claim 1 , wherein the nanoparticles comprise poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA).

4 . The method of claim 1 , wherein the supramolecular hydrogel comprises from 1 wt % to 2 wt % of the hydrophobically modified cellulose derivative.

5 . The method of claim 1 , wherein the hydrophobically modified cellulose derivative comprises one or more of hydroxypropylmethylcellulose (HPMC), hydroxyethyl cellulose (HEC), hydroxypropylcellulose (HPC), ethylcellulose (EC), methylcellulose (MC), hydroxyethylmethylcellulose (HEMC), carboxymethylcellulose (CMC), or carboxymethyl ethyl cellulose (CMEC).

6 . The method of claim 1 , wherein the hydrophobically modified cellulose derivative is a cellulose derivative modified with a hydrophobic saturated alkyl moiety, a hydrophobic unsaturated alkyl moiety, or a hydrophobic aryl moiety.

7 . The method of claim 1 , wherein the supramolecular hydrogel is shear-thinning.

8 . The method of claim 1 , wherein the supramolecular hydrogel is self-healing.

9 . The method of claim 1 , wherein the supramolecular hydrogel is applied by injecting, spreading, or spraying.

10 . The method of claim 1 , wherein the tissue comprises one or more of abdominal tissue, orthopedic tissue, thoracic tissue, cardiac tissue, or gynecologic tissue.

11 . A method comprising:
administering a dynamically cross-linked hydrogel to a tissue to inhibit adhesion formation, the dynamically cross-linked hydrogel comprising non-covalent interactions between a hydrophobically modified cellulose derivative and a plurality of nanoparticles.

12 . The method of claim 11 , wherein the dynamically cross-linked hydrogel comprises from 5 wt % to 10 wt % of the nanoparticles.

13 . The method of claim 11 , wherein the nanoparticles comprise poly(ethylene glycol)-block-poly(lactic acid) (PEG-PLA).

14 . The method of claim 11 , wherein the dynamically cross-linked hydrogel comprises from 1 wt % to 2 wt % of the hydrophobically modified cellulose derivative.

15 . The method of claim 11 , wherein the hydrophobically modified cellulose derivative comprises one or more of hydroxypropylmethylcellulose (HPMC), hydroxyethyl cellulose (HEC), hydroxypropylcellulose (HPC), ethylcellulose (EC), methylcellulose (MC), hydroxyethylmethylcellulose (HEMC), carboxymethylcellulose (CMC), or carboxymethyl ethyl cellulose (CMEC).

16 . The method of claim 11 , wherein the hydrophobically modified cellulose derivative is a cellulose derivative modified with a hydrophobic saturated alkyl moiety, a hydrophobic unsaturated alkyl moiety, or a hydrophobic aryl moiety.

17 . The method of claim 11 , wherein the dynamically cross-linked hydrogel is shear-thinning.

18 . The method of claim 11 , wherein the dynamically cross-linked hydrogel is self-healing.

19 . The method of claim 11 , wherein the dynamically cross-linked hydrogel is administered by injecting, spreading, or spraying.

20 . The method of claim 11 , wherein the tissue comprises one or more of abdominal tissue, orthopedic tissue, thoracic tissue, cardiac tissue, or gynecologic tissue.

Assignees

• Univ Leland Stanford Junior

Inventors

• Appel Eric Andrew
• Woo Y Joseph
• Stapleton Lyndsay

Classifications

• C08L1/26

  Cellulose ethers · CPC title

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• C08L1/08

  Cellulose derivatives · CPC title

• A61L31/145

  Hydrogels or hydrocolloids · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title