Process of recovering 3-hydroxypropionic acid and slurry composition comprising 3-hydroxypropionic acid

Patent metadata

Field	Value
Publication number	US-2024286989-A1
Application number	US-202218569334-A
Country	US
Kind code	A1
Filing date	Nov 24, 2022
Priority date	Nov 29, 2021
Publication date	Aug 29, 2024
Grant date	—

Abstract

The present invention relates to a process of recovering 3-hydroxypropionic acid, comprising: forming a 3-hydroxypropionate crystal in a concentrate containing 3-hydroxypropionic acid in the presence of an alkali metal salt; preparing a solution containing the 3-hydroxypropionate crystal separated from the concentrate; and adding ammonia to the solution containing the 3-hydroxypropionate crystal, and a slurry composition comprising a precipitate prepared in the process of recovering 3-hydroxypropionic acid, and 3-hydroxypropionic acid.

First claim

1 . A process of recovering 3-hydroxypropionic acid, comprising:
forming a 3-hydroxypropionate crystal in a concentrate containing 3-hydroxypropionic acid in the presence of an alkali metal salt; preparing a solution containing the 3-hydroxypropionate crystal separated from the concentrate; and adding ammonia to the solution containing the 3-hydroxypropionate crystal.

2 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
a slurry composition containing a precipitate represented by the following structural formula 3 is formed during the adding ammonia to the solution containing the 3-hydroxypropionate crystal;
Cation(OH) p   [Structural Formula 3]

wherein, Cation is a cation of the alkali metal salt, and p is the number of a hydroxide ion (OH − ) that binds to the cation, which is an integer of 1 or more.

3 . The process of recovering 3-hydroxypropionic acid according to claim 2 , further comprising:
filtering the slurry composition to recover a filtrate, and stripping ammonia from the filtrate under a reduced pressure condition.

4 . The process of recovering 3-hydroxypropionic acid according to claim 3 , further comprising:
adding an adsorbent to the filtrate from which the ammonia has been removed to adsorb ammonium ions.

5 . The process of recovering 3-hydroxypropionic acid according to claim 4 , wherein:
the adsorbent is at least one selected from the group consisting of zeolite, activated carbon, silica gel, and alumina gel.

6 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the concentrate contains at least 300 g/L of the 3-hydroxypropionic acid.

7 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the concentrate contains 350 g/L or more and 900 g/L or less of the 3-hydroxypropionic acid.

8 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the 3-hydroxypropionate crystal is represented by the following structural formula 1 or structural formula 2:
Cation(3HP)n  [Structural Formula 1]

Cation(3HP)n·mH 2 O  [Structural Formula 2]

wherein, Cation is a cation of an alkali metal salt, 3HP is 3-hydroxypropionic acid that binds to the cation, n is the number of 3HP that binds to the cation, which is an integer of 1 or more, and m is the number of water molecules in the hydrate, which is an integer of 1 or more.

9 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the alkali metal salt is Ca(OH) 2 , Mg(OH) 2 or a mixture thereof.

10 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the 3-hydroxypropionate crystal has a particle size distribution D 50 of 20 μm or more and 90 μm or less, and (D 90 −D 10 )/D 50 of 1.00 or more and 3.00 or less.

11 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
the solution containing the 3-hydroxypropionate crystal contains 100 g/L or more and 800 g/L or less of the 3-hydroxypropionate crystal.

12 . The process of recovering 3-hydroxypropionic acid according to claim 1 , further comprising:
fermenting a bacterium strain having 3-hydroxypropionic acid-producing ability to produce a 3-hydroxypropionic acid fermentation liquid; and concentrating the fermentation liquid to form the concentrate containing 3-hydroxypropionic acid.

13 . The process of recovering 3-hydroxypropionic acid according to claim 1 , wherein:
a recovery rate of 3-hydroxypropionic acid is at least 40%.

14 . A 3-hydroxypropionic acid-containing slurry composition, comprising a precipitate represented by the following structural formula 4 and 3-hydroxypropionic acid:
Cation(OH) p   [Structural Formula 4]
wherein, Cation is Mg 2+ or Ca 2+ , and p is the number of hydroxide ion (OH − ) that binds to the cation, which is an integer of 1 or more.

15 . The slurry composition according to claim 14 ,
further comprising ammonia and ammonium ions.

Assignees

• Lg Chemical Ltd

Inventors

• Bang Yongju
• Kim Jeong Eun
• Choe Jae Hoon
• Kang Donggyun
• Jung Woochul
• Han Sang Won
• Kim Taeho

Classifications

• C12Y205/01017

  Cob(I)yrinic acid a,c-diamide adenosyltransferase (2.5.1.17) · CPC title

• C12Y102/01003

  Aldehyde dehydrogenase (NAD+) (1.2.1.3) · CPC title

• C12P7/42

  Hydroxy-carboxylic acids · CPC title

• C12N9/1085

  transferring alkyl or aryl groups other than methyl groups (2.5) · CPC title

• C12N9/0008

  acting on the aldehyde or oxo group of donors (1.2) · CPC title