Specimen processing apparatus

Patent metadata

Field	Value
Publication number	US-2024254471-A1
Application number	US-202218561218-A
Country	US
Kind code	A1
Filing date	May 27, 2022
Priority date	May 31, 2021
Publication date	Aug 1, 2024
Grant date	—

Abstract

A specimen processing apparatus 1000 comprising: a plurality of container holders 510 holding, in one row, a plurality of second nucleic acid containers housing the nucleic acids; a pitch conversion mechanism 500 converting a pitch of the plurality of container holders between a smaller pitch and a larger pitch; a plurality of treatment lanes extracting the plurality of nucleic acid from a plurality of specimens in parallel; a first nozzle unit 200 including a plurality of first nozzles 210 disposed in one row at the greater pitch and moving over the plurality of treatment lanes; a PCR plate 128 having a plurality of wells disposed in one row at the smaller pitch; a second nozzle unit 300 including a plurality of second nozzles 310 disposed in one row at the smaller pitch and moving between a location above the plurality of container holders having the smaller pitch and a location above the PCR plate 128; and a control unit controlling operation of respective parts.

First claim

1 . A specimen processing apparatus extracting nucleic acids from each of a plurality of specimens, the specimen processing apparatus comprising:
a plurality of container holders configured to hold a plurality of first specimen containers and/or a plurality of first nucleic acid containers in one row along a first direction, the plurality of first specimen containers housing the plurality of specimens along the first direction, the plurality of first nucleic acid containers housing the nucleic acids extracted along the first direction; a pitch conversion mechanism configured to convert a pitch of the plurality of container holders along the first direction between a smaller pitch and a larger pitch; a plurality of processing lanes extending in a second direction in parallel in order to concurrently extract the nucleic acids from the plurality of specimens; a first nozzle unit including a plurality of first nozzles arranged in one row along the first direction at the larger pitch, the first nozzle unit being configured to move over the plurality of processing lanes along the second direction; a second container housing unit configured to house a plurality of second specimen containers and/or a plurality of second nucleic acid containers, the plurality of second specimen containers being arranged in one row along the first direction at the smaller pitch, the plurality of second nucleic acid containers being arranged in one row along the first direction at the smaller pitch; a second nozzle unit including a plurality of second nozzles arranged in one row along the first direction at the smaller pitch, the second nozzle unit being configured to move between a region above the plurality of container holders set to the smaller pitch and a region above the second container housing unit; and a control unit configured to control an operation of the pitch conversion mechanism, an operation of the first nozzle unit, and an operation of the second nozzle unit.

2 . The specimen processing apparatus according to claim 1 , comprising a main moving mechanism configured to move the first nozzle unit in the second direction.

3 . The specimen processing apparatus according to claim 1 , wherein the main moving mechanism moves the second nozzle unit in the second direction.

4 . The specimen processing apparatus according to claim 1 , wherein the main moving mechanism moves the first nozzle unit and the second nozzle unit as an integral body.

5 . The specimen processing apparatus according to claim 1 , comprising a sub-moving mechanism configured to move the second nozzle unit in the first direction.

6 . The specimen processing apparatus according to claim 1 , wherein the second container housing unit that houses the plurality of second nucleic acid containers is a PCR plate having a plurality of wells.

7 . The specimen processing apparatus according to claim 1 , comprising a pitch conversion mechanism moving mechanism configured to move the pitch conversion mechanism in the first direction.

8 . The specimen processing apparatus according to claim 1 , wherein the plurality of container holders, the pitch conversion mechanism, and the plurality of processing lanes are disposed on a first stage.

9 . The specimen processing apparatus according to claim 8 , wherein the first nozzle unit moves over the first stage.

10 . The specimen processing apparatus according to claim 8 , wherein the first stage is provided with a dispensing tip disposal unit configured to dispose of dispensing tips mounted on the plurality of first nozzles and/or dispensing tips mounted on the plurality of second nozzles.

11 . The specimen processing apparatus according to claim 1 , wherein the second container housing unit is disposed on a second stage.

12 . The specimen processing apparatus according to claim 11 , comprising a cooling mechanism configured to cool the second container housing unit.

13 . The specimen processing apparatus according to claim 11 , wherein the second nozzle unit moves over at least the second stage.

14 . The specimen processing apparatus according to claim 1 , wherein the plurality of container holders house the plurality of specimen containers at a position closer to the plurality of processing lanes than the plurality of nucleic acid containers in the second direction.

15 . The specimen processing apparatus according to claim 1 , wherein the pitch conversion mechanism includes a plurality of holder support parts, a link mechanism, a slide piece, and a slide piece drive mechanism, the plurality of holder support parts being configured to support the plurality of container holders such that each of the plurality of container holders is movable in the first direction, the link mechanism being connected to the plurality of holder support parts, the slide piece being configured to cause the link mechanism to slide between the smaller pitch and the larger pitch, the slide piece drive mechanism being configured to drive the slide piece.

Assignees

• Universal Bio Research Co Ltd

Inventors

• Tajima Hideji

Classifications

• G01N35/04

  Details of the conveyor system {(G01N35/021 - G01N35/028 take precedence)} · CPC title

• G01N2035/0413

  moving in one dimension · CPC title

• G01N35/1074 Primary

  arranged in a two-dimensional array · CPC title

• G01N35/1081

  characterised by the means for relatively moving the transfer device and the containers in an horizontal plane (G01N35/1011 takes precedence) · CPC title

• C12N15/1003 Primary

  Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor · CPC title