Anti-norovirus antibody

Patent metadata

Field	Value
Publication number	US-2024230649-A1
Application number	US-202218562078-A
Country	US
Kind code	A1
Filing date	May 20, 2022
Priority date	May 20, 2021
Publication date	Jul 11, 2024
Grant date	—

Abstract

Disclosed is an anti-norovirus antibody that reacts with noroviruses of many genotypes and can collectively detect the noroviruses. The anti-norovirus antibody or an antigen-binding fragment thereof undergoes antigen-antibody reaction with the peptides composed of the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2, respectively. The anti-norovirus antibody, which can broadly bind to noroviruses and detect a wide range of human noroviruses with high specificity and sensitivity, and a norovirus immunoassay and a norovirus immunoassay device, both using the anti-norovirus antibody, are provided.

First claim

1 . An anti-norovirus antibody which undergoes antigen-antibody reaction with the peptides composed of the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2, respectively, or an antigen-binding fragment thereof.

2 . The anti-norovirus antibody of claim 1 or an antigen-binding fragment thereof, whose epitope is the whole or a part of the amino acid sequence of SEQ ID NO: 3.

3 . The anti-norovirus antibody of claim 1 or an antigen-binding fragment thereof, wherein the anti-norovirus antibody is a monoclonal antibody.

4 . An immunoassay of norovirus utilizing the antigen-antibody reaction between norovirus in a sample and the anti-norovirus antibody of claim 1 or an antigen-binding fragment thereof.

5 . An immunoassay device of norovirus, comprising the anti-norovirus antibody of claim 1 or an antigen-binding fragment thereof.

6 . The anti-norovirus antibody of claim 2 or an antigen-binding fragment thereof, wherein the anti-norovirus antibody is a monoclonal antibody.

7 . An immunoassay of norovirus utilizing the antigen-antibody reaction between norovirus in a sample and the anti-norovirus antibody of claim 2 or an antigen-binding fragment thereof.

8 . An immunoassay device of norovirus, comprising the anti-norovirus antibody of claim 2 or an antigen-binding fragment thereof.

Assignees

• Denka Company Ltd

Inventors

• Saito Yuji
• Hiraoka Koji
• Ogasawara Shinya

Classifications

• C07K16/106

  Picornaviridae (F), e.g. hepatitis A virus · CPC title

• G01N2469/10

  Detection of antigens from microorganism in sample from host · CPC title

• G01N2333/085

  Picornaviridae, e.g. coxsackie virus, echovirus, enterovirus · CPC title

• G01N33/56983 Primary

  Viruses · CPC title

• G01N33/54387

  Immunochromatographic test strips · CPC title