Calcium and fluorine ions releasing dental composition

Patent metadata

Field	Value
Publication number	US-2024216228-A1
Application number	US-202218556736-A
Country	US
Kind code	A1
Filing date	Mar 20, 2022
Priority date	Apr 29, 2021
Publication date	Jul 4, 2024
Grant date	—

Abstract

The invention relates to a dental composition comprising polymerizable components, an initiator suitable for curing the polymerizable components, a Ca-ions releasing component having a Ca-ions releasing capability of 400 to 700 mg/l (ppm) if 2.5 g Ca-ions releasing component is steered in 50 ml de-ionized water having a pH of 2 for 24 hours; a F-ions releasing component having a F-ions releasing capability of 1,500 to 3,500 mg/l (ppm) if 2.5 g F-ions releasing component is steered in 50 ml de-ionized water having a pH of 7 for 24 hours. The invention also relates to a kit of parts comprising such a dental composition according and the following items alone or in combination: dental adhesive, dental milling block, prefabricated dental crown. The dental composition is suitable for use in a process of remineralizing a defect tooth in the mouth of a mammal, the process comprising the step of fixing a dental restoration to the surface of the defect tooth with the dental composition.

First claim

1 . A dental composition comprising polymerizable components,
initiator suitable for curing the polymerizable components, a Ca-ions releasing component having a Ca-ions releasing capability of 400 to 700 mg/l if 2.5 g Ca-ions releasing component is steered in 50 ml de-ionized water having a pH of 2 for 24 hours, a F-ions releasing component having a F-ions releasing capability of 1,500 to 3,500 mg/l if 2.5 g F-ions releasing component is steered in 50 ml de-ionized water having a pH of 7 for 24 hours, the amount of Ca-ions releasing component contained in the dental composition being higher than the amount of F-ions releasing component with respect to weight.

2 . The dental composition according to claim 1 , the Ca-ions releasing component comprising a basic core material that releases Ca-ions, and an inorganic shell material comprising a metal oxide surrounding the core.

3 . The dental composition according to claim 1 , the Ca-ions releasing component comprising a basic core material comprising a CaO component, in particular a calcium silicate such as 3CaO—SiO 2 and 2CaO—SiO 2 , and an inorganic shell material comprising Al 2 O 3 or SiO 2 surrounding the core.

4 . The dental composition according to claim 1 , the F-ions releasing component being characterized by the following features alone or in combination:
molecular weight: 110 to 300 g/mol; water solubility: 3 to 20 g/l water at 23° C.

5 . The dental composition according to claim 1 , the F-ions releasing component having the formula A n MF m with
A being an alkali metal ion or NR 4 + , with R being C 1 to C 18 alkyl, phenyl or substituted phenyl, M being selected from Ti, Zr, Al, Zn, P, n being 1 to 3, m being 3 to 6.

6 . The dental composition according to claim 1 , the F-ions releasing component being selected from KZnF 3 , K 2 TiF 6 , and mixtures thereof.

7 . The dental composition according to claim 1 , the ratio of Ca-ions releasing component contained in the dental composition to F-ions releasing component being in a range of 1:0.9 to 1:0.1 with respect to weight.

8 . The dental composition according to claim 1 , the Ca-ions releasing component and the F-ions releasing component being present in the dental composition in amounts sufficient to enable a release of
F-ions in an amount of at least 10 ppm per 1 g of cured composition stored in de-ionized water over 30 days at 36° C., and Ca-ions in an amount of at least 2 ppm per 1 g of cured composition stored in de-ionized water over 30 days at 36° C.

9 . The dental composition according to claim 1 , the initiator comprising a redox-initiator system comprising an oxidizing agent, a reducing agent, and optionally a transition metal component, the reducing agent being a thiourea component comprising a (meth)acrylate moiety.

10 . The dental composition according to claim 1 , the dental composition being a resin-modified glass ionomer cement composition comprising
polymerizable components with acidic moiety, polymerizable components without acidic moiety, polyacid, water, acid-reactive glass, a Ca-ions releasing component comprising a basic core comprising a material that releases Ca-ions, and an inorganic shell material comprising a metal oxide surrounding the core, a F-ions releasing component having the formula A n MF m with A being an alkali metal ion or NR 4 + , R being C 1 to C 18 alkyl, phenyl or substituted phenyl, M being selected from Ti, Zr, Al, Zn, P, n being 1 to 3, m being 3 to 6, a redox-initiating system comprising an oxidizing agent, a reducing agent, and optionally a transition metal component, optionally non acid-reactive filler, optionally additive(s).

11 . The dental composition according to claim 1 , comprising the components in the following amounts:
polymerizable components with acidic moiety in an amount of 0.5 to 15 wt. %, polymerizable components without acidic moiety in an amount of 1 to 50 wt. %, polyacid in an amount of 1 to 25 wt. %, acid-reactive glass in an amount of 5 to 70 wt. %, water in an amount of 0.25 to 20 wt. %, non acid-reactive filler in an amount of 0 to 40 wt. %, Ca-ions releasing component comprising a basic core comprising a material that releases Ca-ions, and an inorganic shell material comprising a metal oxide surrounding the core, in an amount of 0.5 to 30 wt. %, F-ions releasing component having the formula A n MF m with A being an alkali metal ion or NR 4 + , R being C 1 to C 18 alkyl, phenyl or substituted phenyl, M being selected from Ti, Zr, Al, Zn, P, n being 1 to 3, m being 3 to 6, in an amount of 0.1 to 20 wt. %, redox-initiating system comprising an oxidizing agent, a reducing agent, and optionally a transition metal component, in an amount of 0.2 to 6 wt. %, photo-initiator in an amount of 0 to 2 wt. %, additives in an amount of 0 to 15 wt. %, wt. % with respect to the weight of the whole composition.

12 . The dental composition according to claim 1 , not comprising the following components alone or in combination:
NaF in an amount of more than 0.5 wt. %; AlF 3 anhydrous in an amount of more than 0.5 wt. %; CaCO 3 in an amount of more than 0.5 wt. %; CaCl 2 ) in an amount of more than 0.5 wt. %; Ca(OH) 2 in an amount of more than 0.5 wt. %; wt. % with respect to the whole composition.

13 . The dental composition according to claim 1 , being provided as a kit of parts comprising an acidic part and a non-acidic part, the acidic part and the non-acidic part being preferably provided in a ratio of 3:1 to 1:3 with respect to volume,
the acidic part comprising polymerizable components with acidic moiety, polymerizable components without acidic moiety, an oxidizing component, polyacid, non acid-reactive filler, water, the non-acidic part comprising polymerizable components without acidic moiety, optionally a photo-initiator, reducing agent, preferably a (polymerizable) thiourea reducing agent, acid-reactive glass, Ca-ions releasing component, F-ions releasing component.

14 . A kit of parts comprising the dental composition according to claim 1 , including the following items alone or in combination: dental adhesive, dental milling block, prefabricated dental crown.

15 . (canceled)

16 . A kit of parts comprising the dental composition according to claim 13 , including the following items alone or in combination: dental adhesive, dental milling block, prefabricated dental crown.

Assignees

• 3M Innovative Properties Company

Inventors

• Claussen Kai U
• Leykauff Johannes M
• Raia Gioacchino
• Hecht Reinhold
• Christensen Randilynn B

Classifications

• A61K6/802

  comprising ceramics · CPC title

• A61K6/889

  Polycarboxylate cements; Glass ionomer cements · CPC title

• A61K6/76

  comprising silicon-containing compounds · CPC title

• A61K6/71

  Fillers · CPC title

• A61K6/30 Primary

  Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives · CPC title